Search Results - "Bornstein, M B"

A placebo-controlled, double-blind, randomized, two-center, pilot trial of cop 1 in chronic progressive multiple sclerosis by BORNSTEIN, M. B, MILLER, A, BROWN, S, ARNON, R, JACOBSON, I, TEITELBAUM, D, SELA, M, WEITZMAN, M, DREXLER, E, KEILSON, M, SPADA, V, WEISS, W, APPEL, S, ROLAK, L, HARATI, Y

“…We found Cop 1 to be effective and relatively safe in a previous (exacerbating-remitting) clinical trial. This current trial involves 106 chronic-progressive…”
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A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis by Bornstein, M B, Miller, A, Slagle, S, Weitzman, M, Crystal, H, Drexler, E, Keilson, M, Merriam, A, Wassertheil-Smoller, S, Spada, V

“…Cop 1 is a random polymer (molecular weight, 14,000 to 23,000) simulating myelin basic protein. It is synthesized by polymerizing L-alanine, L-glutamic acid,…”
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Rapid Degradation Restricts Measles Virus Matrix Protein Expression in a Subacute Sclerosing Panencephalitis Cell Line by Sheppard, Rachel D., Raine, Cedric S., Bornstein, Murray B., Udem, Stephen A.

“…Measles virus matrix protein expression is restricted in the persistently infected brain cells of patients with the chronic neurological disease subacute…”
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The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis by Brosnan, C F, Bornstein, M B, Bloom, B R

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Transformation of cells of astrocyte lineage into macrophage-like cells in organotypic cultures of mouse spinal cord tissue by Kusaka, H, Hirano, A, Bornstein, M B, Moore, G R, Raine, C S

“…Phagocytic cells on the surface of the explants and their relationships to the surface were examined morphologically and immunocytochemically in organotypic…”
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Multiple sclerosis: trial of a synthetic polypeptide by Bornstein, M B, Miller, A I, Teitelbaum, D, Arnon, R, Sela, M

“…A synthetic polypeptide, copolymer I (COP I), composed of alanine, glutamic acid, lysine, and tyrosine, has been demonstrated to be nonencephalitogenic and…”
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Augmentation of immune-mediated demyelination by lipid haptens by Raine, C S, Traugott, U, Farooq, M, Bornstein, M B, Norton, W T

“…The encephalitogenic effects of bovine galactocerbroside and total myelin lipids given in the presence or absence of a known encephalitogenic dose of bovine…”
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Hopeful prospects in multiple sclerosis by Bornstein, M B

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Quantitation of antigen-specific T-cell-induced demyelination in vitro by Lyman, W D, Roth, G A, Brosnan, C F, Bornstein, M B, Raine, C S

“…To test the hypothesis that T lymphocytes sensitized to central nervous system (CNS) antigens may quantitatively induce more demyelination in neural tissue…”
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Electrophysiological analysis of factors involved in the primary demyelinating diseases: the rabbit eye model system by Arezzo, J C, Brosnan, C F, Schroeder, C E, Litwak, M S, Bornstein, M B

“…This study explores the longitudinal assessment of visual evoked potentials (VEPs) in the rabbit as a method for defining factors underlying functional and…”
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The organization of astrocytes in organotypic mouse spinal cord culture: an electron microscope study by Kusaka, H, Hirano, A, Bornstein, M B, Raine, C S

“…The organization of astrocytes in myelinated culture of mouse spinal cord tissue was analysed ultrastructurally and compared with the pattern in vivo…”
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Basal lamina formation by astrocytes in organotypic cultures of mouse spinal cord tissue by Kusaka, H, Hirano, A, Bornstein, M B, Raine, C S

“…The relationship between astrocytes, basal lamina and mesenchymal tissue was analyzed ultrastructurally in myelinated organotypic cultures of mouse spinal cord…”
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Antigen-specific T cells can mediate demyelination in organotypic central nervous system cultures by Lyman, W D, Roth, G A, Chiu, F C, Brosnan, C F, Bornstein, M B, Raine, C S

“…To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to…”
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Fine structure of astrocytic processes during serum-induced demyelination in vitro by Kusaka, H, Hirano, A, Bornstein, M B, Raine, C S

“…Astrocytic changes were examined ultrastructurally during serum-induced demyelination in organotypic cultures of mouse spinal cord tissue. The myelin sheaths…”
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The effect of serum from ALS patients on organotypic nerve and muscle tissue cultures by Liveson, J, Frey, H, Bornstein, M B

“…Serum from 11 ALS patients was assayed for cytotoxic activity using several different organ culture models. No specific neurotoxic activity was found. Slight…”
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Clinical trial design in multiple sclerosis therapy by Weiss, William, Bornstein, Murray B., Miller, Aaron, Slagle, Susan

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Immunogenic potentials of copolymer I in normal human lymphocytes by BROSNAN, C. F, LITWAK, M, NEIGHBOUR, P. A, LYMAN, W. D, CARTER, T. H, BORNSTEIN, M. B, BLOOM, B. R

“…Copolymer I (COP I), a nonencephalitogenic polypeptide analogous to myelin basic protein, is currently being tested for possible effectiveness in treating MS…”
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Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis by Lyman, W D, Sonett, J R, Brosnan, C F, Elkin, R, Bornstein, M B

“…Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune…”
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Measles Virus Matrix Protein Synthesized in a Subacute Sclerosing Panencephalitis Cell Line by Sheppard, Rachel D., Raine, Cedric S., Bornstein, Murray B., Udem, Stephen A.

“…Measles virus generally produces acute illness. Rarely, however, persistent infection of brain cells occurs, resulting in a chronic and fatal neurological…”
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Quantitative chemical analysis of demyelination in cultured mouse spinal cord by Roth, G A, Bornstein, M B

“…These studies were designed to determine whether chemical parameters can be used to quantify the demyelinative potency of anti-CNS sera or other demyelinating…”
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