Search Results - "Bornman, M."

Whole-Genome Sequencing Reveals Elevated Tumor Mutational Burden and Initiating Driver Mutations in African Men with Treatment-Naïve, High-Risk Prostate Cancer by Jaratlerdsiri, Weerachai, Chan, Eva K F, Gong, Tingting, Petersen, Desiree C, Kalsbeek, Anton M F, Venter, Philip A, Stricker, Phillip D, Bornman, M S Riana, Hayes, Vanessa M

“…: African-American men are more likely than any other racial group to die from prostate cancer. The contribution of acquired genomic variation to this racial…”
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TMPRSS2‐ERG fusions linked to prostate cancer racial health disparities: A focus on Africa by Blackburn, James, Vecchiarelli, Stefano, Heyer, Erin E., Patrick, Sean M., Lyons, Ruth J., Jaratlerdsiri, Weerachai, Zyl, Smit, Bornman, M. S. Riana, Mercer, Tim R., Hayes, Vanessa M.

“…Background The androgen‐regulated gene TMPRSS2 to the ETS transcription factor gene ERG fusion is the most common genomic alteration acquired during prostate…”
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African-specific molecular taxonomy of prostate cancer by Jaratlerdsiri, Weerachai, Jiang, Jue, Gong, Tingting, Patrick, Sean M., Willet, Cali, Chew, Tracy, Lyons, Ruth J., Haynes, Anne-Maree, Pasqualim, Gabriela, Louw, Melanie, Kench, James G., Campbell, Raymond, Horvath, Lisa G., Chan, Eva K. F., Wedge, David C., Sadsad, Rosemarie, Brum, Ilma Simoni, Mutambirwa, Shingai B. A., Stricker, Phillip D., Bornman, M. S. Riana, Hayes, Vanessa M.

“…Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan…”
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Human origins in a southern African palaeo-wetland and first migrations by Chan, Eva K. F., Timmermann, Axel, Baldi, Benedetta F., Moore, Andy E., Lyons, Ruth J., Lee, Sun-Seon, Kalsbeek, Anton M. F., Petersen, Desiree C., Rautenbach, Hannes, Förtsch, Hagen E. A., Bornman, M. S. Riana, Hayes, Vanessa M.

“…Anatomically modern humans originated in Africa around 200 thousand years ago (ka) 1 – 4 . Although some of the oldest skeletal remains suggest an eastern…”
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Prostate cancer genetic risk and associated aggressive disease in men of African ancestry by Soh, Pamela X. Y., Mmekwa, Naledi, Petersen, Desiree C., Gheybi, Kazzem, van Zyl, Smit, Jiang, Jue, Patrick, Sean M., Campbell, Raymond, Jaratlerdseri, Weerachai, Mutambirwa, Shingai B. A., Bornman, M. S. Riana, Hayes, Vanessa M.

“…African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of…”
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Microbial community profiling of human saliva using shotgun metagenomic sequencing by Hasan, Nur A, Young, Brian A, Minard-Smith, Angela T, Saeed, Kelly, Li, Huai, Heizer, Esley M, McMillan, Nancy J, Isom, Richard, Abdullah, Abdul Shakur, Bornman, Daniel M, Faith, Seth A, Choi, Seon Young, Dickens, Michael L, Cebula, Thomas A, Colwell, Rita R

“…Human saliva is clinically informative of both oral and general health. Since next generation shotgun sequencing (NGS) is now widely used to identify and…”
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The impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities by Huang, Ruotian, Bornman, M. S. Riana, Stricker, Phillip D., Simoni Brum, Ilma, Mutambirwa, Shingai B. A., Jaratlerdsiri, Weerachai, Hayes, Vanessa M.

“…The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve genomic integrity and chromosomal stability. In turn, genomic instability…”
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MethylToSNP: identifying SNPs in Illumina DNA methylation array data by LaBarre, Brenna A, Goncearenco, Alexander, Petrykowska, Hanna M, Jaratlerdsiri, Weerachai, Bornman, M S Riana, Hayes, Vanessa M, Elnitski, Laura

“…Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and…”
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Metagenomic analysis reveals a rich bacterial content in high‐risk prostate tumors from African men by Feng, Ye, Jaratlerdsiri, Weerachai, Patrick, Sean M., Lyons, Ruth J., Haynes, Anne‐Maree, Collins, Colin C., Stricker, Phillip D., Bornman, M.S. Riana, Hayes, Vanessa M.

“…Background Inflammation is a hallmark of prostate cancer (PCa), yet no pathogenic agent has been identified. Men from Africa are at increased risk for both…”
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Linking African ancestral substructure to prostate cancer health disparities by Gheybi, Kazzem, Mmekwa, Naledi, Lebelo, Maphuti Tebogo, Patrick, Sean M., Campbell, Raymond, Nenzhelele, Mukudeni, Soh, Pamela X. Y., Obida, Muvhulawa, Loda, Massimo, Shirindi, Joyce, Butler, Eboneé N., Mutambirwa, Shingai B. A., Bornman, M. S. Riana, Hayes, Vanessa M.

“…Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at…”
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Alterations in the Epigenetic Machinery Associated with Prostate Cancer Health Disparities by Craddock, Jenna, Jiang, Jue, Patrick, Sean M, Mutambirwa, Shingai B A, Stricker, Phillip D, Bornman, M S Riana, Jaratlerdsiri, Weerachai, Hayes, Vanessa M

“…Prostate cancer is driven by acquired genetic alterations, including those impacting the epigenetic machinery. With African ancestry as a significant risk…”
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ANO7 African-ancestral genomic diversity and advanced prostate cancer by Jiang, Jue, Soh, Pamela X. Y., Mutambirwa, Shingai B. A., Bornman, M. S. Riana, Haiman, Christopher A., Hayes, Vanessa M., Jaratlerdsiri, Weerachai

“…Background Prostate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate specific…”
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Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men by McCrow, John P., Petersen, Desiree C., Louw, Melanie, Chan, Eva K. F., Harmeyer, Katherine, Vecchiarelli, Stefano, Lyons, Ruth J., Bornman, M. S. Riana, Hayes, Vanessa M.

“…BACKGROUND Prostate cancer incidence and mortality rates are significantly increased in African–American men, but limited studies have been performed within…”
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Evaluating Germline Testing Panels in Southern African Males With Advanced Prostate Cancer by Gheybi, Kazzem, Jiang, Jue, Mutambirwa, Shingai B A, Soh, Pamela X Y, Kote-Jarai, Zsofia, Jaratlerdsiri, Weerachai, Eeles, Rosalind A, Bornman, M S Riana, Hayes, Vanessa M

“…Germline testing for prostate cancer is on the increase, with clinical implications for risk assessment, treatment, and management. Regardless of family…”
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DDT contamination from indoor residual spraying for malaria control by Van Dyk, J.C., Bouwman, H., Barnhoorn, I.E.J., Bornman, M.S.

“…The insecticide DDT is still used in specific areas of South Africa for indoor residual spray (IRS) to control malaria vectors. Local residents could be…”
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Organochlorine pesticide levels in Clarias gariepinus from polluted freshwater impoundments in South Africa and associated human health risks by Barnhoorn, I.E.J., van Dyk, J.C., Genthe, B., Harding, W.R., Wagenaar, G.M., Bornman, M.S.

“…•Clarias gariepinus muscle tissue bio-accumulated organochlorine pesticides.•Predicted risk of developing cancer is higher than the recommended safe value of…”
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DNA methylation profiles unique to Kalahari KhoeSan individuals by Goncearenco, Alexander, LaBarre, Brenna A., Petrykowska, Hanna M., Jaratlerdsiri, Weerachai, Bornman, M. S. Riana, Turner, Stephen D., Hayes, Vanessa M., Elnitski, Laura

“…Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with…”
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Revised timeline and distribution of the earliest diverged human maternal lineages in southern Africa by Chan, Eva K F, Hardie, Rae-Anne, Petersen, Desiree C, Beeson, Karen, Bornman, Riana M S, Smith, Andrew B, Hayes, Vanessa M

“…The oldest extant human maternal lineages include mitochondrial haplogroups L0d and L0k found in the southern African click-speaking forager peoples broadly…”
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Clinical presentation of prostate cancer in Black South Africans by Tindall, Elizabeth A., Monare, L. Richard, Petersen, Desiree C., van Zyl, Smit, Hardie, Rae-Anne, Segone, Alpheus M., Venter, Philip A., Bornman, M.S. Riana, Hayes, Vanessa M.

“…BACKGROUND Compared with White Americans, Black American men are at a significant increased risk of presenting with prostate cancer (PCa) and associated…”
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African KhoeSan ancestry linked to high-risk prostate cancer by Petersen, Desiree C, Jaratlerdsiri, Weerachai, van Wyk, Abraham, Chan, Eva K F, Fernandez, Pedro, Lyons, Ruth J, Mutambirw, Shingai B A, van der Merwe, Andre, Venter, Philip A, Bates, William, Bornman, M S Riana, Hayes, Vanessa M

“…Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of southern Africa. South African populations represent admixture…”
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