Search Results - "Borner, M. M."

Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients by Zlobec, I, Hädrich, M, Dawson, H, Koelzer, V H, Borner, M, Mallaev, M, Schnüriger, B, Inderbitzin, D, Lugli, A

“…Background: In colorectal cancer (CRC), tumour budding at the invasion front is associated with lymph node (LN) and distant metastasis. Interestingly, tumour…”
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Bevacizumab continuation versus no continuation after first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a randomized phase III non-inferiority trial (SAKK 41/06) by Koeberle, D., Betticher, D.C., von Moos, R., Dietrich, D., Brauchli, P., Baertschi, D., Matter, K., Winterhalder, R., Borner, M., Anchisi, S., Moosmann, P., Kollar, A., Saletti, P., Roth, A., Frueh, M., Kueng, M., Popescu, R.A., Schacher, S., Hess, V., Herrmann, R.

“…In this trial, stopping bevacizumab after completion of induction chemotherapy was associated with a shorter time to progression, but no statistically…”
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Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway by Pirnia, F, Schneider, E, Betticher, D C, Borner, M M

“…Caspase-3 activity has been described to be essential for drug-induced apoptosis. Recent results suggest that in addition to its downstream executor function,…”
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Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore by Aartsen, M. G, Ackermann, M, Adams, J, Aguilar, J. A, Ahlers, M, Ahrens, M, Al Samarai, I

“…We present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days…”
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Docetaxel, Cisplatin, and Fluorouracil; Docetaxel and Cisplatin; and Epirubicin, Cisplatin, and Fluorouracil As Systemic Treatment for Advanced Gastric Carcinoma: A Randomized Phase II Trial of the Swiss Group for Clinical Cancer Research by ROTH, Arnaud D, FAZIO, Nicola, WERNLI, Martin, LESLIE, Martin, GLYNNE-JONES, Robert, WIDMER, Lukas, SEYMOUR, Matthew, DE BRAUD, Filippo, STUPP, Roger, FALK, Stephen, BERNHARD, Jürg, SALETTI, Piercarlo, KÖBERLE, Dieter, BORNER, Markus M, RUFIBACH, Kaspar, MAIBACH, Rudolf

“…This randomized phase II trial evaluated two docetaxel-based regimens to see which would be most promising according to overall response rate (ORR) for…”
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Neoadjuvant chemoradiotherapy with or without panitumumab in patients with wild-type KRAS, locally advanced rectal cancer (LARC): a randomized, multicenter, phase II trial SAKK 41/07 by Helbling, D., Bodoky, G., Gautschi, O., Sun, H., Bosman, F., Gloor, B., Burkhard, R., Winterhalder, R., Madlung, A., Rauch, D., Saletti, P., Widmer, L., Borner, M., Baertschi, D., Yan, P., Benhattar, J., Leibundgut, E.O., Bougel, S., Koeberle, D.

“…We conducted a randomized, phase II, multicenter study to evaluate the anti-epidermal growth factor receptor (EGFR) mAb panitumumab (P) in combination with…”
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The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression by VONLANTHEN, S, HEIGHWAY, J, ALTERMATT, H. J, GUGGER, M, KAPPELER, A, BORNER, M. M, VAN LOHUIZEN, M, BETTICHER, D. C

“…Genes of the polycomb group function by silencing homeotic selector genes that regulate embryogenesis. In mice, downregulation of one of the polycomb genes,…”
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Search for Astrophysical Sources of Neutrinos Using Cascade Events in IceCube by Ackermann, M., Ahlers, M., Ahrens, M., Al Samarai, I., Anderson, T., Ansseau, I., Axani, S., Bai, X., Barwick, S. W., Baum, V., Tjus, J. Becker, Berley, D., Binder, G., Bindig, D., Bohm, C., Böser, S., Botner, O., Braun, J., Brenzke, M., Casier, M., Cheung, E., Cowen, D. F., Cross, R., De Ridder, S., de With, M., DeYoung, T., di Lorenzo, V., Ehrhardt, T., Fazely, A. R., Felde, J., Finley, C., Franckowiak, A., Friedman, E., Gerhardt, L., Giang, W., Halzen, F., Hanson, K., Hellauer, R., Hill, G. C., Hoffman, K. D., Hokanson-Fasig, B., Hoshina, K., Karg, T., Keivani, A., Kim, J., Kittler, T., Klein, S. R., Kolanoski, H., Kopper, C., Kopper, S., Koschinsky, J. P., Koskinen, D. J., Kowalski, M., Kroll, M., Kunwar, S., Kyriacou, A., Labare, M., Lauber, F., Leuermann, M., Luszczak, W., Mahn, K. B. M., Mancina, S., Mase, K., McNally, F., Nakarmi, P., Naumann, U., Neer, G., Nowicki, S. C., Palczewski, T., Peiffer, P., Rädel, L., Relich, M., Richman, M., Robertson, S., Rott, C., Herrera, S. E. Sanchez, Sandrock, A., Sarkar, S., Satalecka, K., Schlunder, P., Seckel, D., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Sullivan, G. W., Terliuk, A., Tilav, S., Tobin, M. N., Tselengidou, M., Ty, B., Walck, C., Weaver, C., Wickmann, S., Wiebe, K., Williams, D. R., Wolf, M., Wood, J., Yanez, J. P., Yoshida, S., Yuan, T.

“…The IceCube neutrino observatory has established the existence of a flux of high-energy astrophysical neutrinos, which is inconsistent with the expectation…”
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Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer by Borner, M.M, Schöffski, P, de Wit, R, Caponigro, F, Comella, G, Sulkes, A, Greim, G, Peters, G.J, van der Born, K, Wanders, J, de Boer, R.F, Martin, C, Fumoleau, P

“…The aim of this study was to determine the patient's preference for oral UFT/leucovorin (LV) or intravenous (i.v.) 5-fluorouracil (5-FU)/LV chemotherapy in…”
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A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicity by Borner, M. M., Bernhard, J., Dietrich, D., Popescu, R., Wernli, M., Saletti, P., Rauch, D., Herrmann, R., Koeberle, D., Honegger, H., Brauchli, P., Lanz, D., Roth, A. D.

“…Background: To determine the efficacy, impact on quality-of-life (QoL) and tolerability of two different irinotecan administration schedules in combination…”
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Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial by Scheithauer, W., McKendrick, J., Begbie, S., Borner, M., Burns, W. I., Burris, H. A., Cassidy, J., Jodrell, D., Koralewski, P., Levine, E. L., Marschner, N., Maroun, J., Garcia-Alfonso, P., Tujakowski, J., Van Hazel, G., Wong, A., Zaluski, J., Twelves, C.

“…Background: Oral capecitabine achieves a superior response rate with an improved safety profile compared with bolus 5-fluorouracil–leucovorin (5-FU/LV) as…”
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Successful challenge with the fully human EGFR antibody panitumumab following an infusion reaction with the chimeric EGFR antibody cetuximab by Helbling, D, Borner, M

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Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: a randomized phase II trial of the Swiss Group for Clinical Cancer Research SAKK by Borner, M., Koeberle, D., Von Moos, R., Saletti, P., Rauch, D., Hess, V., Trojan, A., Helbling, D., Pestalozzi, B., Caspar, C., Ruhstaller, T., Roth, A., Kappeler, A., Dietrich, D., Lanz, D., Mingrone, W.

“…To determine the activity and tolerability of adding cetuximab to the oxaliplatin and capecitabine (XELOX) combination in first-line treatment of metastatic…”
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Ecology and conservation: contributions to One Health by Cleaveland, S, Borner, M, Gislason, M

“…Although One Health is widely promoted as a more effective approach towards human, animal and ecosystem health, the momentum is still driven largely by health…”
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Adjuvant therapy after excision and radiation of isolated postmastectomy locoregional breast cancer recurrence: definitive results of a phase III randomized trial (SAKK 23/82) comparing tamoxifen with observation by Waeber, M., Castiglione-Gertsch, M., Dietrich, D., Thürlimann, B., Goldhirsch, A., Brunner, K. W., Borner, M. M.

“…Background: Adjuvant systemic treatment for patients with isolated locoregional recurrence (ILRR) of breast cancer is based on a single reported randomized…”
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Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02) by Ruhstaller, T., Widmer, L., Schuller, J.C., Roth, A., Hess, V., Mingrone, W., von Moos, R., Borner, M., Pestalozzi, B.C., BalmerMajno, S., Köberle, D., Terraciano, L., Schnider, A., Bodis, S., Popescu, R.

“…This multicenter phase II study investigated the efficacy and feasibility of preoperative induction chemotherapy followed by chemoradiation and surgery in…”
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PG490-mediated sensitization of lung cancer cells to Apo2L TRAIL-induced apoptosis requires activation of ERK2 by FRESE, Steffen, PIRNIA, Farzaneh, MIESCHER, Daniela, KRAJEWSKI, Stan, BORNER, Markus M, REED, John C, SCHMID, Ralph A

“…Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to the family of programmed cell death-inducing cytokines. Apo2L/TRAIL induces…”
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Alternative Splicing of the Human Cyclin D-binding Myb-like Protein (hDMP1) Yields a Truncated Protein Isoform That Alters Macrophage Differentiation Patterns by Tschan, Mario P., Fischer, Kimberlee M., Fung, Vivian S., Pirnia, Farzaneh, Borner, Markus M., Fey, Martin F., Tobler, Andreas, Torbett, Bruce E.

“…We have cloned two novel, alternatively spliced messages of human cyclin D-binding Myb-like protein (hDMP1). The known, full-length protein has been named…”
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Phase II Study of Capecitabine and Oxaliplatin in First- and Second-Line Treatment of Advanced or Metastatic Colorectal Cancer by BORNER, Markus M, DIETRICH, Daniel, MÜLLER, Samuel, BRAUCHLI, Peter, CASTIGLIONE-GERTSCH, Monica, GOLDHIRSCH, Aron, ROTH, Arnaud D, STUPP, Roger, MORANT, Rudolf, HONEGGER, Hanspeter, WERNLI, Martin, HERRMANN, Richard, PESTALOZZI, Bernhard C, SALETTI, Piercarlo, HANSELMANN, Silvia

“…To determine the efficacy and tolerability of combining oxaliplatin with capecitabine in the treatment of advanced nonpretreated and pretreated colorectal…”
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Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer by BORNER, M. M, BROUSSET, P, PFANNER-MEYER, B, BACCHI, M, VONLANTHEN, S, HOTZ, M. A, ALTERMATT, H. J, SCHLAIFER, D, REED, J. C, BETTICHER, D. C

“…Proteins of the Bcl-2 family as well as p53 are important regulators of apoptosis. Alterations in the expression of these proteins can contribute to the…”
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