Search Results - "Born, Ilona"

Synthesis and characterization of a new and radiolabeled high-affinity substrate for H⁺/peptide cotransporters by Knütter, Ilka, Hartrodt, Bianka, Tóth, Géza, Keresztes, Attila, Kottra, Gabor, Mrestani-Klaus, Carmen, Born, Ilona, Daniel, Hannelore, Neubert, Klaus, Brandsch, Matthias

“…In this study we described the design, rational synthesis and functional characterization of a novel radiolabeled hydrolysis-resistant high-affinity substrate…”
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Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors by Roessler, Claudia, Nowak, Theresa, Pannek, Martin, Gertz, Melanie, Nguyen, Giang T. T., Scharfe, Michael, Born, Ilona, Sippl, Wolfgang, Steegborn, Clemens, Schutkowski, Mike

“…Sirtuins are NAD+‐dependent deacetylases acting as sensors in metabolic pathways and stress response. In mammals there are seven isoforms. The mitochondrial…”
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Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes by Reinhold, Dirk, Vetter, Robert W, Mnich, Kati, Bühling, Frank, Lendeckel, Uwe, Born, Ilona, Faust, Jürgen, Neubert, Klaus, Gollnick, Harald, Ansorge, Siegfried

“…Various studies have shown that the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26), expressed on T, NK, and B cells in the human immune system, is…”
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Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo by Steinbrecher, Andreas, Reinhold, Dirk, Quigley, Laura, Gado, Ameer, Tresser, Nancy, Izikson, Leonid, Born, Ilona, Faust, Jürgen, Neubert, Klaus, Martin, Roland, Ansorge, Siegfried, Brocke, Stefan

“…Abstract CD26 or dipeptidyl peptidase IV (DP IV) is expressed on various cell types, including T cells. Although T cells can receive activating signals via…”
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Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors by Roessler, Claudia, Nowak, Theresa, Pannek, Martin, Gertz, Melanie, Nguyen, Giang T. T., Scharfe, Michael, Born, Ilona, Sippl, Wolfgang, Steegborn, Clemens, Schutkowski, Mike

“…Sirtuins are NAD+‐dependent deacetylases acting as sensors in metabolic pathways and stress response. In mammals there are seven isoforms. The mitochondrial…”
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A Novel Inhibitor of the Mammalian Peptide Transporter PEPT1 by Knütter, Ilka, Theis, Stephan, Hartrodt, Bianka, Born, Ilona, Brandsch, Matthias, Daniel, Hannelore, Neubert, Klaus

“…This study was initiated to develop inhibitors of the intestinal H+/peptide symporter. We provide evidence that the dipeptide derivative Lys[Z(NO2)]-Pro is an…”
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Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor- β1 (TGF- β1) in stimulated mouse splenocytes and thymocytes by Reinhold, Dirk, Bank, Ute, Bühling, Frank, Täger, Michael, Born, Ilona, Faust, Jürgen, Neubert, Klaus, Ansorge, Siegfried

“…Various studies have shown that the ectoenzyme dipeptidyl peptidase IV (DP IV, CD26), expressed on T, NK and B cells in the human immune system, is involved in…”
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Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones by Reinhold, Dirk, Hemmer, Bernhard, Gran, Bruno, Born, Ilona, Faust, Jürgen, Neubert, Klaus, McFarland, Henry F, Martin, Roland, Ansorge, Siegfried

“…The ectoenzyme dipeptidyl peptidase IV (DP IV, EC 3.4.14.5, CD26) has been shown to play a crucial role in T cell activation. Specific inhibitors of DP IV…”
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Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides by Stöckel-Maschek, Angela, Stiebitz, Beate, Faust, Jürgen, Born, Ilona, Kähne, Thilo, Gorrell, Mark D, Neubert, Klaus

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Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26) by Kähne, T, Reinhold, D, Neubert, K, Born, I, Faust, J, Ansorge, S

“…DP IV (CD26) represents an accessory surface molecule playing an important role in the process of activation and proliferation of human lymphocytes. The…”
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Decisive structural determinants for the interaction of proline derivatives with the intestinal H+/peptide symporter by Brandsch, Matthias, Knütter, Ilka, Thunecke, Frank, Hartrodt, Bianka, Born, Ilona, Börner, Volker, Hirche, Frank, Fischer, Gunter, Neubert, Klaus

“…To elucidate the decisive structural factors relevant for dipeptide–carrier interaction, the affinity of short amide and imide derivatives for the intestinal…”
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Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease by Reinhold, D, Hemmer, B, Gran, B, Steinbrecher, A, Brocke, S, Kähne, T, Wrenger, S, Born, I, Faust, J, Neubert, K, Martin, R, Ansorge, S

“…The ectoenzyme dipeptidyl peptidase IV (DP IV; EC 3.4.14.5; CD26) has been shown to play a crucial role in T cell activation. In the present study, we show by…”
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DNA synthesis in cultured human keratinocytes and HaCaT keratinocytes is reduced by specific inhibition of dipeptidyl peptidase IV (CD26) enzymatic activity by Vetter, R, Reinhold, D, Bühling, F, Lendeckel, U, Born, I, Faust, J, Neubert, K, Ansorge, S, Gollnick, H

“…The ectopeptidase dipeptidyl peptidase IV (DP IV, CD26, EC 3.4.14.5) is present on most mammalian cells. Using specific inhibitors of DP IV, it has been shown…”
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Dipeptidyl peptidase IV in inflammatory CNS disease by Steinbrecher, A, Reinhold, D, Quigley, L, Gado, A, Tresser, N, Izikson, L, Born, I, Faust, J, Neubert, K, Martin, R, Ansorge, S, Brocke, S

“…Current pathogenic concepts of inflammatory demyelinating disorders such as multiple sclerosis (MS) are based on the hypothesis that a T cell-mediated…”
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Probing substrate backbone function in prolyl oligopeptidase catalysis--large positional effects of peptide bond monothioxylation by Schutkowski, M, Jakob, M, Landgraf, G, Born, I, Neubert, K, Fischer, G

“…Site-specific effects on the catalytic activity of prolyl oligopeptidase from human placenta were studied using oligopeptide substrates in which a peptide bond…”
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Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes by Schön, E, Born, I, Demuth, H U, Faust, J, Neubert, K, Steinmetzer, T, Barth, A, Ansorge, S

“…Dipeptidyl peptidase IV (DP IV) is a membrane peptidase playing a significant role in the process of activation and proliferation of human thymus-derived…”
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Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis by Schutkowski, Mike, Jakob, Mario, Landgraf, Grit, Born, Ilona, Neubert, Klaus, Fischer, Gunter

“…Site‐specific effects on the catalytic activity of prolyl oligopeptidase from human placenta were studied using oligopeptide substrates in which a peptide bond…”
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Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-{{beta}}1 Secretion In Vivo by Steinbrecher, Andreas, Reinhold, Dirk, Quigley, Laura, Gado, Ameer, Tresser, Nancy, Izikson, Leonid, Born, Ilona, Faust, Jurgen, Neubert, Klaus, Martin, Roland, Ansorge, Siegfried, Brocke, Stefan

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