Search Results - "Born, A."

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity by Yu, Yi, Leete, Thomas C., Born, David A., Young, Lauren, Barrera, Luis A., Lee, Seung-Joo, Rees, Holly A., Ciaramella, Giuseppe, Gaudelli, Nicole M.

“…Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with…”
Get full text

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects by Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.

“…Only a small fraction of early drug programs progress to the market, due to safety and efficacy failures, despite extensive efforts to predict safety…”
Get full text

Seizures in Alzheimer’s disease by Born, H.A

“…Highlights • Clinical data from familial and sporadic AD patients reveal increased seizure risk. • Many APP-linked AD mouse models develop seizures and other…”
Get full text

Isonitrile Formation by a Non‐Heme Iron(II)‐Dependent Oxidase/Decarboxylase by Harris, Nicholas C., Born, David A., Cai, Wenlong, Huang, Yaobing, Martin, Joelle, Khalaf, Ryan, Drennan, Catherine L., Zhang, Wenjun

“…The electron‐rich isonitrile is an important functionality in bioactive natural products, but its biosynthesis has been restricted to the IsnA family of…”
Get full text

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease by Born, Heather A, Kim, Ji-Yoen, Savjani, Ricky R, Das, Pritam, Dabaghian, Yuri A, Guo, Qinxi, Yoo, Jong W, Schuler, Dorothy R, Cirrito, John R, Zheng, Hui, Golde, Todd E, Noebels, Jeffrey L, Jankowsky, Joanna L

“…Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be fundamentally connected to cognitive dysfunction. Supporting this link,…”
Get full text

Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice by Born, Heather A., Dao, An T., Levine, Amber T., Lee, Wai Ling, Mehta, Natasha M., Mehra, Shubhangi, Weeber, Edwin J., Anderson, Anne E.

“…Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly caused by deletion or mutation of the maternal allele of the UBE3A gene, with…”
Get full text

Bistability of the Atlantic subpolar gyre in a coarse-resolution climate model by Levermann, A., Born, A.

“…High resolution models indicate that the dynamics of the Nordic Seas and the subpolar gyre is crucial for deep water formation and overturning circulation in…”
Get full text

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator by Han, Harry J, Allen, Carolyn C, Buchovecky, Christie M, Yetman, Michael J, Born, Heather A, Marin, Miguel A, Rodgers, Shaefali P, Song, Bryan J, Lu, Hui-Chen, Justice, Monica J, Probst, Frank J, Jankowsky, Joanna L

“…The tet-off system has been widely used to create transgenic models of neurological disorders including Alzheimer's, Parkinson's, Huntington's, and prion…”
Get full text

Melting of Northern Greenland during the last interglaciation by Born, A, Nisancioglu, K. H

“…Using simulated climate data from the comprehensive coupled climate model IPSL CM4, we simulate the Greenland ice sheet (GrIS) during the Eemian…”
Get full text

Transition to University and Vigorous Physical Activity: Implications for Health and Psychological Well-Being by Bray, Steven R, Born, Heidi A

“…The authors investigated vigorous physical activity and psychological well-being during transition from high school to first-year university in a sample of 145…”
Get full text

Author Correction: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects by Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.

“…In the original version of this article, there were errors in the labelling of the colours in the key of Figure 2, whereby the labeling of the third and fourth…”
Get full text

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome by Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., Adhikari, A., Fenton, T. A., Pedersen, L. R., Noakes, L. S., Nieman, B. J., Lerch, J. P., Harris, S., Born, H. A., Peters, M. M., Deng, P., Cameron, D. L., Fink, K. D., Beitnere, U., O’Geen, H., Anderson, A. E., Dindot, S. V., Nash, K. R., Weeber, E. J., Wöhr, M., Ellegood, J., Segal, D. J., Silverman, J. L.

“…Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia,…”
Get full text

Influence of ice sheet topography on Greenland precipitation during the Eemian interglacial by Merz, N., Gfeller, G., Born, A., Raible, C. C., Stocker, T. F., Fischer, H.

“…Greenland precipitation and its relationship to the synoptic forcing has been studied for the last interglacial period (i.e., the Eemian) using a set of global…”
Get full text

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome by Berg, Elizabeth L, Petkova, Stela P, Born, Heather A, Adhikari, Anna, Anderson, Anne E, Silverman, Jill L

“…Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is…”
Get full text

Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice by Amssoms, Katie, Born, Philip A, Beugeling, Max, De Clerck, Ben, Van Gulck, Ellen, Hinrichs, Wouter L J, Frijlink, Henderik W, Grasmeijer, Niels, Kraus, Guenter, Sutmuller, Roger, Simmen, Kenny, Baert, Lieven

“…A single-injection vaccine formulation that provides for both a prime and a boost immunization would have various advantages over a multiple-injection regime…”
Get full text

Late Eemian warming in the Nordic Seas as seen in proxy data and climate models by Born, A., Nisancioglu, K. H., Risebrobakken, B.

“…We analyze a transient simulation of the last glacial inception in a climate model of intermediate complexity, focusing on sea ice–ocean circulation dynamics…”
Get full text

Assessing the Immunomodulatory Effect of Size on the Uptake and Immunogenicity of Influenza- and Hepatitis B Subunit Vaccines In Vitro by Heida, Rick, Born, Philip A., Tapia-Calle, Gabriela, Frijlink, Henderik W., Salvati, Anna, Huckriede, Anke L. W., Hinrichs, Wouter L. J.

“…Viral subunit vaccines are a safer and more tolerable alternative to whole inactivated virus vaccines. However, they often come with limited efficacy,…”
Get full text

Accelerated cerebral white matter development in preterm infants: A voxel-based morphometry study with diffusion tensor MR imaging by Giménez, Mónica, Miranda, Maria J., Born, A. Peter, Nagy, Zoltan, Rostrup, Egill, Jernigan, Terry L.

“…Twenty-seven preterm infants were compared to 10 full-term infants at term equivalent age using a voxel-based analysis of diffusion tensor imaging of the…”
Get full text

Climate and carbon cycle dynamics in a CESM simulation from 850 to 2100 CE by Lehner, F, Joos, F, Raible, C. C, Mignot, J, Born, A, Keller, K. M, Stocker, T. F

“…Under the protocols of phase 3 of the Paleoclimate Modelling Intercomparison Project, a number of simulations were produced that provide a range of potential…”
Get full text

Dependence of Eemian Greenland temperature reconstructions on the ice sheet topography by Merz, N, Born, A, Raible, C. C, Fischer, H, Stocker, T. F

“…The influence of a reduced Greenland Ice Sheet (GrIS) on Greenland's surface climate during the Eemian interglacial is studied using a set of simulations with…”
Get full text