Search Results - "Borlongan, Cesar"
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The central role of peripheral inflammation in ischemic stroke
Published in Journal of Cerebral Blood Flow & Metabolism (01-05-2023)“…Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation, a critical secondary cell death mechanism in stroke, has been…”
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An update on stem cell therapy for stroke patients: Where are we now?
Published in Journal of Cerebral Blood Flow & Metabolism (01-09-2024)“…Abstract With a foundation built upon initial work from the 1980s demonstrating graft viability in cerebral ischemia, stem cell transplantation has shown…”
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3
MicroRNA-133a and Myocardial Infarction
Published in Cell Transplantation (01-07-2019)“…Myocardial infarction (MI) is the leading cause of morbidity and mortality in the world. The infarcted heart displays typical cell death cascades characterized…”
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4
Age of PISCES: stem-cell clinical trials in stroke
Published in The Lancet (British edition) (20-08-2016)“…Negative results in clinical trials of stem-cell therapy for stroke could put regenerative medicine in this area in jeopardy, as for Parkinson's disease when…”
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Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications
Published in International Journal of Molecular Sciences (31-05-2013)“…Wharton's jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ that has…”
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Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms
Published in Progress in neurobiology (01-11-2017)“…Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of…”
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Recent advances in cell therapy for stroke
Published in Journal of cerebral blood flow and metabolism (01-10-2021)“…The last 50 years have witnessed the translation of stem cell therapy from the laboratory to the clinic for treating brain disorders, in particular stroke…”
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Going straight for the gut: gut-brain axis pathology and treatment of Parkinson's disease
Published in Neural regeneration research (01-10-2024)Get full text
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Traumatic brain injury treatment using a rodent model of homelessness
Published in Neural regeneration research (01-09-2024)Get full text
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Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson’s disease
Published in Proceedings of the National Academy of Sciences - PNAS (19-06-2018)“…Borlongan discusses the paper by Ren et al. which reveals that an enzyme called soluble epoxide hydrolase (sEH) may be key to the demise of the brain…”
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Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury
Published in International journal of molecular sciences (09-01-2014)“…Traumatic brain injury (TBI) occurs in response to an acute insult to the head and is recognized as a major risk factor for Alzheimer's disease (AD). Indeed,…”
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Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke
Published in Stroke (1970) (01-09-2015)“…BACKGROUND AND PURPOSE—Adult stem cell therapy is an experimental stroke treatment. Here, we assessed homing and anti-inflammatory effects of bone marrow…”
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Quite amusing stem cells: Muse cells
Published in Neural regeneration research (01-11-2023)Get full text
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Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
Published in PloS one (03-01-2013)“…The long-term consequences of traumatic brain injury (TBI), specifically the detrimental effects of inflammation on the neurogenic niches, are not very well…”
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15
Cell-Based Therapy for Stroke: Musing With Muse Cells
Published in Stroke (1970) (01-09-2020)“…Stem cell-based regenerative therapies may rescue the central nervous system following ischemic stroke. Mesenchymal stem cells exhibit promising regenerative…”
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Eye Opener in Stroke: Mitochondrial Dysfunction and Stem Cell Repair in Retinal Ischemia
Published in Stroke (1970) (01-08-2019)“…BACKGROUND AND PURPOSE—Retinal ischemia is a major cause of visual impairment in stroke patients, but our incomplete understanding of its pathology may…”
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Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury
Published in PloS one (12-03-2014)“…Traumatic brain injury (TBI) is associated with neuro-inflammation, debilitating sensory-motor deficits, and learning and memory impairments. Cell-based…”
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A gut feeling about stroke reveals gut-brain axis’ active role in homeostasis and dysbiosis
Published in Journal of cerebral blood flow and metabolism (01-05-2020)“…Peripheral inflammatory responses accompany many neurological disorders, including stroke. The gut-brain axis opens new avenues in our understanding of stroke…”
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Enhancing oxidative phosphorylation over glycolysis for energy production in cultured mesenchymal stem cells
Published in Neuroreport (12-10-2022)“…Objective Strokes represent as one of the leading causes of death and disability in the USA, however, there is no optimal treatment to reduce the occurrence or…”
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Preliminary Reports of Stereotaxic Stem Cell Transplants in Chronic Stroke Patients
Published in Molecular therapy (01-10-2016)Get full text
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