Search Results - "Borkhardt, A."

MiR-125 in normal and malignant hematopoiesis by Shaham, L, Binder, V, Gefen, N, Borkhardt, A, Izraeli, S

“…MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs ( hsa-miR-125b-1 ,…”
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Editorial Expression of Concern: Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells by Ehrhardt, H., Häcker, S., Wittmann, S., Maurer, M., Borkhardt, A., Toloczko, A., Debatin, K-M, Fulda, S., Jeremias, I.

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EP06.08: Influence of prenatal risk factors on the prevalence of preleukemic ETV6: RUNX1 lesions in cord blood by Quintanilla, L. Benitez, Fischer, U., Crispi, F., Castro‐Barquero, S., Crovetto, F., Sola, M. Larroya, Youssef, L., Castillo, H., Bueno, C., Borras, R., Borkhardt, A., Vieta, E., Estruch, R., Menendez, P., Gratacos, E.

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Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin by Bhatia, S, Reister, S, Mahotka, C, Meisel, R, Borkhardt, A, Grinstein, E

“…AC133 is a prominent surface marker of CD34+ and CD34− hematopoietic stem/progenitor cell (HSPC) subsets. AC133+ HSPCs contain high progenitor cell activity…”
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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing by Landgraf, Pablo, Rusu, Mirabela, Sheridan, Robert, Sewer, Alain, Iovino, Nicola, Aravin, Alexei, Pfeffer, Sébastien, Rice, Amanda, Kamphorst, Alice O., Landthaler, Markus, Lin, Carolina, Socci, Nicholas D., Hermida, Leandro, Fulci, Valerio, Chiaretti, Sabina, Foà, Robin, Schliwka, Julia, Fuchs, Uta, Novosel, Astrid, Müller, Roman-Ulrich, Schermer, Bernhard, Bissels, Ute, Inman, Jason, Phan, Quang, Chien, Minchen, Weir, David B., Choksi, Ruchi, De Vita, Gabriella, Frezzetti, Daniela, Trompeter, Hans-Ingo, Hornung, Veit, Teng, Grace, Hartmann, Gunther, Palkovits, Miklos, Di Lauro, Roberto, Wernet, Peter, Macino, Giuseppe, Rogler, Charles E., Nagle, James W., Ju, Jingyue, Papavasiliou, F. Nina, Benzing, Thomas, Lichter, Peter, Tam, Wayne, Brownstein, Michael J., Bosio, Andreas, Borkhardt, Arndt, Russo, James J., Sander, Chris, Zavolan, Mihaela, Tuschl, Thomas

“…MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In…”
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Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A by Auer, F, Rüschendorf, F, Gombert, M, Husemann, P, Ginzel, S, Izraeli, S, Harit, M, Weintraub, M, Weinstein, O Y, Lerer, I, Stepensky, P, Borkhardt, A, Hauer, J

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Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53 by Gefen, N, Binder, V, Zaliova, M, Linka, Y, Morrow, M, Novosel, A, Edry, L, Hertzberg, L, Shomron, N, Williams, O, Trka, J, Borkhardt, A, Izraeli, S

“…MicroRNAs (miRNAs) regulate the expression of multiple proteins in a dose-dependent manner. We hypothesized that increased expression of miRNAs encoded on…”
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P313: RECURRENT PATHOGENIC GERMLINE CHEK2 VARIANTS IN PEDIATRIC PATIENTS WITH HEMATOLOGICAL MALIGNANCIES by Brozou, T., Wagener, R., Fischer, U., Borkhardt, A.

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Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases by Linka, R M, Risse, S L, Bienemann, K, Werner, M, Linka, Y, Krux, F, Synaeve, C, Deenen, R, Ginzel, S, Dvorsky, R, Gombert, M, Halenius, A, Hartig, R, Helminen, M, Fischer, A, Stepensky, P, Vettenranta, K, Köhrer, K, Ahmadian, M R, Laws, H-J, Fleckenstein, B, Jumaa, H, Latour, S, Schraven, B, Borkhardt, A

“…The purpose of this study was the appraisal of the clinical and functional consequences of germline mutations within the gene for the IL-2 inducible T-cell…”
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Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment by Eckert, C, Hagedorn, N, Sramkova, L, Mann, G, Panzer-Grümayer, R, Peters, C, Bourquin, J-P, Klingebiel, T, Borkhardt, A, Cario, G, Alten, J, Escherich, G, Astrahantseff, K, Seeger, K, Henze, G, von Stackelberg, A

“…The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during…”
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Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in ‘DC-culture-media’ shifts correlations of released chemokines with antileukemic T-cell reactions by Merle, M., Fischbacher, D., Liepert, A., Grabrucker, C., Kroell, T., Kremser, A., Dreyssig, J., Freudenreich, M., Schuster, F., Borkhardt, A., Kraemer, D., Koehne, C.-H., Kolb, H.J., Schmid, C., Schmetzer, H.M.

“…Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or…”
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Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia by Garcia-Cuellar, M-P, Füller, E, Mäthner, E, Breitinger, C, Hetzner, K, Zeitlmann, L, Borkhardt, A, Slany, R K

“…Mixed-lineage leukemia fusion proteins activate their target genes predominantly by stimulating transcriptional elongation. A core component necessary for this…”
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P320: TCF3‐PBX1 LEUKEMIA INVADES IPSC‐DERIVED CEREBRAL ORGANOIDS by Gebing, P., Hänsch, S., Lenk, L., Schewe, D., Borkhardt, A., Fischer, U., Bhatia, S.

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P312: EMPLOYING WHOLE GENOME OPTICAL MAPPING TO CHARACTERIZE THE LANDSCAPE OF STRUCTURAL VARIANTS IN B‐CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA by Brandes, D., Brozou, T., Soura, S., Bergmann, A., Fischer, U., Borkhardt, A., Wagener, R.

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Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells by Ehrhardt, H, Häcker, S, Wittmann, S, Maurer, M, Borkhardt, A, Toloczko, A, Debatin, K-M, Fulda, S, Jeremias, I

“…Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused,…”
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Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease by Merle, M., Fischbacher, D., Liepert, A., Grabrucker, C., Kroell, T., Kremser, A., Dreyssig, J., Freudenreich, M., Schuster, F., Borkhardt, A., Kraemer, D., Koehne, C.-H., Kolb, H. J., Schmid, C., Schmetzer, H. M.

“…In cancer or hematologic disorders, chemokines act as growth- or survival factors, regulating hematopoiesis and angiogenesis, determining metastatic spread and…”
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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 by Mulaw, M A, Krause, A J, Deshpande, A J, Krause, L F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W-D, Lottaz, C, Bohlander, S K

“…The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute…”
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P337: LONG TERM INFECTION‐DRIVES CHANGES IN THE BONE MARROW MICRO‐ENVIRONMENT OF PAX5+/‐ MICE PREDISPOSED TO B CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA by Liu, W., Stencel, O., Lu, Z., Xu, C., Lang, P., Auer, F., Hauer, J., Fischer, U., Borkhardt, A., Pandyra, A.

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P345: AN IMMUNE SCREEN IDENTIFIES 5‐NONLOXYTRYPTAMINE AS A NOVEL ANTI‐CANCER AGENT CAPABLE OF IMPROVING ANTI‐TUMOR IMMUNITY IN COMBINATION WITH ANTI‐PD1 THERAPY by Stachura, P., Liu, W., Wlodarczyk, A., Xu, C., Bhatia, S., Lang, P. A., Borkhardt, A., Pandyra, A. A.

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ALK fusion genes in children with atypical myeloproliferative leukemia by Röttgers, S, Gombert, M, Teigler-Schlegel, A, Busch, K, Gamerdinger, U, Slany, R, Harbott, J, Borkhardt, A

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