Search Results - "Borkan, S C"

Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells by Li, F, Mao, H P, Ruchalski, K L, Wang, Y H, Choy, W, Schwartz, J H, Borkan, S C

“…The events that precipitate cell death and the stress proteins responsible for cytoprotection during ATP depletion remain elusive. We hypothesize that exposure…”
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Transient ischemia or heat stress induces a cytoprotectant protein in rat kidney by Emami, A, Schwartz, J H, Borkan, S C

“…Sublethal heat exposure induces the production of heat stress protein (HSP) 72 kDa, a reported cytoprotectant, in several tissues including the rat kidney…”
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Prior heat stress enhances survival of renal epithelial cells after ATP depletion by Wang, Y H, Borkan, S C

“…The 72-kDa heat stress protein (HSP-72) is an inducible cytoprotectant protein. Although transient renal ischemia in vivo induces HSP-72, it is not known…”
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c-Src and HSP72 interact in ATP-depleted renal epithelial cells by Wang, Y H, Li, F, Schwartz, J H, Flint, P J, Borkan, S C

“…Disruption of cell contact sites during ischemia contributes to the loss of organ function in acute renal failure. Because prior heat stress protects cell…”
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Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells by Wang, Yihan, Knowlton, Anne A., Christensen, Thomas G., Shih, Theodora, Borkan, Steven C.

“…Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. This study tested the following hypotheses: (a) renal tubular…”
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Heat stress ameliorates ATP depletion-induced sublethal injury in mouse proximal tubule cells by Borkan, S C, Wang, Y H, Lieberthal, W, Burke, P R, Schwartz, J H

“…The role of prior heat stress (HS) in ameliorating changes in the actin cytoskeleton and the loss of tight junction integrity that accompany ATP depletion was…”
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Heat stress protein-associated cytoprotection of inner medullary collecting duct cells from rat kidney by Borkan, S C, Emami, A, Schwartz, J H

“…Although heat stress proteins (HSPs) mediate thermotolerance, the cellular targets of thermal injury and mechanisms of acquired cytoprotection are unknown. To…”
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Hsp72 expression enhances survival in adenosine triphosphate–depleted renal epithelial cells by Wang, Y-H., Knowlton, A. A., Li, F-H., Borkan, S. C.

“…Although prior heat stress (HS) inhibits apoptosis in adenosine phosphate (ATP)-depleted renal epithelial cells (REC), the specific stress protein(s)…”
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A novel cellular survival factor - the B2 subunit of vacuolar H -ATPase inhibits apoptosis by Li, G, Yang, Q, Krishnan, S, Alexander, E A, Borkan, S C, Schwartz, J H

“…The ubiquitous vacuolar H(+)-ATPase, a multisubunit proton pump, is essential for intraorganellar acidification. Disruption of its function leads to…”
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Role of oxygen free radical species in in vitro models of proximal tubular ischemia by Borkan, S C, Schwartz, J H

“…Lipid peroxidation (LP) of cell membranes by oxygen free radical species (OFRS) during reflow may be a mechanism for progressive proximal tubule injury after…”
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Hsp72 Interacts with Paxillin and Facilitates the Reassembly of Focal Adhesions during Recovery from ATP Depletion by Mao, Haiping, Wang, Yihan, Li, Zhijian, Ruchalski, Kathleen L., Yu, Xueqing, Schwartz, John H., Borkan, Steven C.

“…The cytoprotective effect of heat stress proteins on epithelial cell detachment, an important cause of acute, ischemic renal failure, was examined after ATP…”
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Hemoperfusion for N-acetylprocainamide intoxication by Borkan, S C

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Actin filament organization is required for proper cAMP-dependent activation of CFTR by Prat, A G, Cunningham, C C, Jackson, Jr, G R, Borkan, S C, Wang, Y, Ausiello, D A, Cantiello, H F

“…Previous studies have indicated a role of the actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion…”
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cAMP-activated anion conductance is associated with expression of CFTR in neonatal mouse cardiac myocytes by Lader, A S, Wang, Y, Jackson, Jr, G R, Borkan, S C, Cantiello, H F

“…In this study, patch-clamp techniques were applied to cultured neonatal mouse cardiac myocytes (NMCM) to assess the contribution of cAMP stimulation to the…”
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Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator by Cantiello, H F, Jackson, Jr, G R, Grosman, C F, Prat, A G, Borkan, S C, Wang, Y, Reisin, I L, O'Riordan, C R, Ausiello, D A

“…Expression of the cystic fibrosis transmembrane conductance regulator (CFTR), and of at least one other member of the ATP-binding cassette family of transport…”
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Hepatic alpha 2 mu-globulin: a potential metabolic role in the rat proximal tubule by Borkan, S C, Wang, Y H, Lam, K T, Brecher, P, Schwartz, J H

“…In the present study, we provide immunohistochemical and immunologic evidence to localize an abundant, 15.5-kDa protein to the soluble protein fraction of the…”
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Uterine Lysosomal Enzyme Activity during Ovum Implantation and Early Decidualization by Moulton, B C, Koenig, B B, Borkan, S C

“…Changes in lysosomal enzyme activities were measured during early pregnancy in implantation and nonimplantation uterine segments. Increases in arylsulfatase B…”
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Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells by SCHAEFER, Katherine L, WADA, Koichiro, TAKAHASHI, Hirokazu, MATSUHASHI, Nobuyuki, OHNISHI, Shin, WOLFE, M. Michael, TURNER, Jerrold R, NAKAJIMA, Atsushi, BORKAN, Steven C, SAUBERMANN, Lawrence J

“…Activation of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits growth and survival of hepatocellular…”
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Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors by Sinha, Diviya, Wang, Zhiyong, Ruchalski, Kathleen L, Levine, Jerrold S, Krishnan, Selvi, Lieberthal, Wilfred, Schwartz, John H, Borkan, Steven C

“…Mouse proximal tubular cells (BUMPT), when cultured in the absence of growth factors, activate a default apoptotic pathway. Although Wnt signaling antagonizes…”
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Distinct hsp70 Domains Mediate Apoptosis-inducing Factor Release and Nuclear Accumulation by Ruchalski, Kathleen, Mao, Haiping, Li, Zhijian, Wang, Zhiyong, Gillers, Sara, Wang, Yihan, Mosser, Dick D., Gabai, Vladimir, Schwartz, John H., Borkan, Steven C.

“…Although hsp70 antagonizes apoptosis-inducing factor (AIF)-mediated cell death, the relative importance of preventing its release from mitochondria versus…”
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