Search Results - "Borisova, Yulia A"
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A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways
Published in Chemico-biological interactions (01-09-2022)“…In recent decades, indolocarbazole glycosides containing sugar moieties have attracted attention due to their diverse anti-tumor activities. In the present…”
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Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate
Published in Journal of medicinal chemistry (09-12-2021)“…Prostate cancer is the second most common type of cancer among men. Its main method of treatment is chemotherapy, which has a wide range of side effects. One…”
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PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation
Published in European journal of medicinal chemistry (05-01-2022)“…Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of the leading causes of cancer death. The development of approaches to the…”
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Antiproliferative activity of a new derivative from the class of N-glycoside of indolo[2,3-a]pyrrolo[3,4-c]carbazoles
Published in Research results in pharmacology (English ed.) (14-06-2022)“…Introduction: The creation of highly effective original anticancer drugs remains an urgent direction of scientific research in tumor therapy. One of the…”
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Comparative Analysis of Approaches to the Formation of an Institutional Framework for the Development of a Changing Resource Base for Hydrocarbon Production (on the Example of High-viscosity Oils in Alberta (Canada) and the Republic of Tatarstan (Russia))
Published in Georesursy (30-03-2024)“…The modern evolution of the dynamics of the structure of the hydrocarbon resource base in various regions is characterized, as a rule, by the gradual…”
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