Search Results - "Borgoño, Carla A"

The emerging roles of human tissue kallikreins in cancer by Diamandis, Eleftherios P, Borgoño, Carla A

“…Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with…”
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Glucagon Response to Oral Glucose Challenge in Type 1 Diabetes: Lack of Impact of Euglycemia by KRAMER, Caroline K, BORGONO, Carla A, VAN NOSTRAND, Paula, RETNAKARAN, Ravi, ZINMAN, Bernard

“…OBJECTIVE Previous studies have demonstrated aberrant glucagon physiology in the setting of type 1 diabetes (T1D) but have not addressed the potential impact…”
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Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer by Borgoño, Carla A, Michael, Iacovos P, Diamandis, Eleftherios P

“…Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases and are present in at least six mammalian orders. In humans, tissue…”
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A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation by Borgoño, Carla A., Michael, Iacovos P., Komatsu, Nahoko, Jayakumar, Arumugam, Kapadia, Ravi, Clayman, Gary L., Sotiropoulou, Georgia, Diamandis, Eleftherios P.

“…Desquamation of the stratum corneum is a serine protease-dependent process. Two members of the human tissue kallikrein (KLK) family of (chymo)tryptic-like…”
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Insulins: Past, Present, and Future by Borgoño, Carla A., MD, PhD, Zinman, Bernard, MD

“…This article highlights selected milestones in insulin discovery and its continued development as a pivotal therapy for diabetes. The last 90 years have…”
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Expression and Functional Characterization of the Cancer-related Serine Protease, Human Tissue Kallikrein 14 by Borgoño, Carla A., Michael, Iacovos P., Shaw, Julie L.V., Luo, Liu-Ying, Ghosh, Manik C., Soosaipillai, Antoninus, Grass, Linda, Katsaros, Dionyssios, Diamandis, Eleftherios P.

“…Human tissue kallikrein 14 (KLK14) is a novel extracellular serine protease. Clinical data link KLK14 expression to several diseases, primarily cancer;…”
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Determinants of Insulin Resistance in Infants at Age 1 Year: Impact of gestational diabetes mellitus by BORGONO, Carla A, HAMILTON, Jill K, CHANG YE, HANLEY, Anthony J, CONNELLY, Philip W, SERMER, Mathew, ZINMAN, Bernard, RETNAKARAN, Ravi

“…The offspring of women with gestational diabetes mellitus (GDM) display a propensity for the early accrual of cardiometabolic risk factors, including insulin…”
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Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer by BORGONO, Carla A, KISHI, Tadaaki, SCORILAS, Andreas, HARBECK, Nadia, DORN, Julia, SCHMALFELDT, Barbara, SCHMITT, Manfred, DIAMANDIS, Eleftherios P

“…Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8 ) is a steroid hormone–regulated secreted serine protease differentially expressed in ovarian…”
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Defining the extended substrate specificity of kallikrein 1-related peptidases by Borgoño, Carla A, Gavigan, Julie-Ann, Alves, Juliano, Bowles, Ben, Harris, Jennifer L, Sotiropoulou, Georgia, Diamandis, Eleftherios P

“…Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases. KLKs 4, 5, 13 and 14 display altered…”
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Human Kallikrein 13 Protein in Ovarian Cancer Cytosols: A New Favorable Prognostic Marker by SCORILAS, Andreas, BORGONO, Carla A, HARBECK, Nadia, DORN, Julia, SCHMALFELDT, Barbara, SCHMITT, Manfred, DIAMANDIS, Eleftherios P

“…Human kallikrein 13 (hK13; encoded by the KLK13 gene) is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and…”
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Human kallikrein 14: A new potential biomarker for ovarian and breast cancer by BORGONO, Carla A, GRASS, Linda, SOOSAIPILLAI, Antoninus, YOUSEF, George M, PETRAKI, Constantina D, HOWARTH, David H. C, FRACCHIOLI, Stefano, KATSAROS, Dionyssios, DIAMANDIS, Eleftherios P

“…Human kallikrein gene 14 (KLK14) is a recently discovered member of the tissue kallikrein family of secreted serine proteases, which includes…”
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Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14 by Felber, Loyse M., Kündig, Christoph, Borgoño, Carla A., Chagas, Jair R., Tasinato, Andrea, Jichlinski, Patrice, Gygi, Christian M., Leisinger, Hans‐Jürg, Diamandis, Eleftherios P., Deperthes, David, Cloutier, Sylvain M.

“…The reactive center loop (RCL) of serpins plays an essential role in the inhibition mechanism acting as a substrate for their target proteases. Changes within…”
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In-silico Analysis of Kallikrein Gene Expression in Pancreatic and Colon Cancers by YOUSEF, George M, BORGONO, Carla A, POPALIS, Cynthia, YACOUB, George M, POLYMERIS, Mary-Ellen, SOOSAIPILLAI, Antoninus, DIAMANDIS, Eleftherios P

“…Human kallikreins are a cluster of 15 serine protease genes located in the chromosomal band 19q13.4, a non-randomly rearranged region in many solid tumors,…”
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Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer by YOUSEF, George M, FRACCHIOLI, Stefano, SCORILAS, Andreas, BORGONO, Carla A, ISKANDER, Lisa, PUOPOLO, Manuela, MASSOBRIO, Marco, DIAMANDIS, Eleftherios P, KATSAROS, Dionyssios

“…To study KLK14 gene expression in endocrine-related cancers, we studied its hormonal regulation in breast and ovarian cancer cell lines. Our kinetic and…”
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Enzymatic profiling of human kallikrein 14 using phage-display substrate technology by Felber, Loyse M, Borgoño, Carla A, Cloutier, Sylvain M, Kündig, Christoph, Kishi, Tadaaki, Ribeiro Chagas, Jair, Jichlinski, Patrice, Gygi, Christian M, Leisinger, Hans-Jürg, Diamandis, Eleftherios P, Deperthes, David

“…The human KLK14 gene is one of the newly identified serine protease genes belonging to the human kallikrein family, which contains 15 members. KLK14 , like all…”
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Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis by Diamandis, Eleftherios P, Borgoño, Carla A, Scorilas, Andreas, Yousef, George M, Harbeck, Nadia, Dorn, Julia, Schmalfeldt, Barbara, Schmitt, Manfred

“…Human kallikrein 5 (hK5; encoded by the KLK5 gene) is a secreted serine protease expressed in hormonally regulated tissues, including the breast and ovary. We…”
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In silico analysis of the human kallikrein gene 6 by Yousef, George M, Borgoño, Carla A, White, Nicole M A, Robb, John-Desmond, Michael, Iacovos P, Oikonomopoulou, Katerina, Khan, Saba, Diamandis, Eleftherios P

“…Kallikreins are a family of 15 serine proteases clustered together on the long arm of chromosome 19. Recent reports have linked kallikreins to malignancy. The…”
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Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients by Diamandis, Eleftherios P., Borgoño, Carla A., Scorilas, Andreas, Harbeck, Nadia, Dorn, Julia, Schmitt, Manfred

“…Objectives: Human kallikrein 11 (hK11) is a secreted serine protease, highly expressed in hormonally regulated tissues, including the prostate and the ovary…”
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Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma by Borgoño, Carla A., Fracchioli, Stefano, Yousef, George M., Rigault de la Longrais, Irene A., Luo, Liu‐Ying, Soosaipillai, Antoninus, Puopolo, Manuela, Grass, Linda, Scorilas, Andreas, Diamandis, Eleftherios P., Katsaros, Dionyssios

“…Human kallikrein 11 (hK11/trypsin‐like serine protease/TLSP, encoded by the KLK11 gene) is a member of the kallikrein family of secreted serine proteases…”
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Molecular cloning of a new gene which is differentially expressed in breast and prostate cancers by Yousef, George M, Borgoño, Carla A, Michael, Iacovos P, Davidian, Christine, Stephan, Carsten, Jung, Klaus, Diamandis, Eleftherios P

“…The chromosomal region 19q13 is non-randomly rearranged in many solid tumors. Using the positional candidate gene approach, we cloned a new gene, tentatively…”
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