Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common known genetic cause of inherited and idiopathic Parkinson's disease (PD) in different populations. The predicted multifunctionality of LRRK2 product and the pleomorphic pathology associated with LRRK2 mutations...

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Bibliographic Details
Published in:	Genetic testing Vol. 12; no. 4; p. 471
Main Authors:	Santos-Rebouças, Cíntia B, Abdalla, Cláudia B, Baldi, Fábio José R, Martins, Paloma A, Corrêa, Juliana C, Gonçalves, Andressa P, Cunha, Marcela S, Borges, Margarete B, Pereira, João S, Laks, Jerson, Pimentel, Márcia M G
Format:	Journal Article
Language:	English
Published:	United States 01-12-2008
Subjects:	Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - genetics Brazil Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Parkinsonian Disorders - complications Parkinsonian Disorders - genetics Point Mutation Protein-Serine-Threonine Kinases - genetics
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Summary:	Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common known genetic cause of inherited and idiopathic Parkinson's disease (PD) in different populations. The predicted multifunctionality of LRRK2 product and the pleomorphic pathology associated with LRRK2 mutations place this gene as a potential candidate for other neurodegenerative disorders, mainly Alzheimer's disease (AD). We report a Brazilian male expressing both late-onset AD and slowly progressive parkinsonism signs, and who presented the most frequent LRRK2 mutation (p.G2019S). Although the co-occurrence of PD and AD would be expected occasionally, the shared mechanisms between the two complex disorders are still unclear and are discussed herein. In light of recent findings about the wide role of LRRK2 under normal and pathological conditions, it is tempting to speculate that LRRK2 mutations might play an upstream influence on the etiology of not just PD but also several alpha-synuclein and tau pathologies, including AD.
ISSN:	1090-6576
DOI:	10.1089/gte.2008.0042