Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

Nonsyndromic orofacial clefts (NSOC) are the craniofacial most common congenital malformations. There are evidences that the nonsyndromic cleft palate (NSCP) development differs from other NSOC. However, most of the publications treat NSCP without considering that information. Furthermore, few studi...

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Published in:BMC oral health Vol. 23; no. 1; p. 486
Main Authors: Trezena, Samuel, Machado, Renato Assis, de Almeida Reis, Silvia Regina, Scariot, Rafaela, Rangel, Ana Lúcia Carrinho Ayroza, de Oliveira, Fabrício Emanuel Soares, Borges, Anna Júlia, Silva, Alissa Tamara, Martelli, Daniella R Barbosa, Martelli Júnior, Hercílio
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 14-07-2023
BioMed Central
BMC
Subjects:
Birth defects
Brazil - epidemiology
Care and treatment
Cleft Lip - epidemiology
Cleft lip/palate
Cleft palate
Cleft Palate - epidemiology
Congenital defects
Cross-Sectional Studies
Dental care
Diagnosis
Epidemiology
Families & family life
Family medical history
Female
Females
Genetic aspects
Humans
Isolated cleft palate
Male
Methods
Mothers
Oral clefts
Orofacial clefts
Patients
Pregnancy
Surgery
Brazil
Epidemiology
Oral clefts
Isolated cleft palate
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Summary:Nonsyndromic orofacial clefts (NSOC) are the craniofacial most common congenital malformations. There are evidences that the nonsyndromic cleft palate (NSCP) development differs from other NSOC. However, most of the publications treat NSCP without considering that information. Furthermore, few studies focus on NSCP. The aim of this study was to describe epidemiological findings of patients with isolated NSCP in Brazil. In this cross-sectional multicenter study, four reference Centers for treatment in three different Brazilian states was investigated. Data were obtained from clinical records of patients, between November 2021 and June 2022. Researched variables were sociodemographic, clinical characteristics and pregnancy and family history. Pearson's chi-square and ANOVA One-way tests were used for associations. Majority were female (58.1%), white (60.7%) with incomplete NSCP (61.2%). There was an association between complete NSCP and a positive history of medical problems during pregnancy (p = 0.016; 27.9%; OR: 1.94; 1.12-3.35). Systemic alterations were perceived in 40.6% of the sample with odds ratio for development of the complete type (OR: 1.21; 0.74-1.97). Higher OR was visualized in medication use during pregnancy (OR: 1.35; 0.76-2.37) and positive family history of oral cleft (OR: 1.44; 0.80-2.55). Dental and surgical care was associated with higher age groups (p < 0.050). NSCP was most prevalent in white skin color female. Complete NSCP is associated with medical problems during pregnancy. Medication use during pregnancy and positive family history of oral cleft increase the chance of developing complete NSCP.
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ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-023-03197-3