Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifung...

Full description

Saved in:

Bibliographic Details
Published in:	Chemistry & biodiversity Vol. 21; no. 7; pp. e202400680 - n/a
Main Authors:	Sehnem, Gabriela S., Silva, Julia A., C. Silva, Tiara, Prado, Diego G., Santiago, Mariana B., O. Santos, Anna Lívia, Martins, Mário M., Cunha, Luis C. S., Sousa, Raquel M. F., Romero, Rosana, Bittar, Vinicius P., Borges, Ana Luiza S., Martins, Carlos H. G., Espindola, Foued S., Oliveira, Alberto
Format:	Journal Article
Language:	English
Published:	Switzerland Wiley Subscription Services, Inc 01-07-2024
Subjects:	Acetic acid alpha-Amylases - antagonists & inhibitors alpha-Amylases - metabolism Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antidiabetic Antifungal Antifungal activity Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antioxidant Antioxidants Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological activity Candida - drug effects Chemical composition Chromatography, High Pressure Liquid Diabetes mellitus Ethyl acetate Flavonoids Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Fungicides Global health Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Liquid chromatography Melastomataceae Melastomataceae - chemistry Microbial Sensitivity Tests Natural products Pharmacology Phenolic acids Phenolic compounds Phenols Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Public health Triterpenoids α-Amylase Melastomataceae Antifungal Antioxidant Phenolic compounds Antidiabetic
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95–3.90 μg mL−1) and potent antioxidant activity in the DPPH (1.74±0.07 μg mL−1), FRAP (654.01±42.09 μmol ETrolox/gsample), and ORAC (3698.88±37.28 μmol ETrolox/gsample) methods. The EE displayed inhibition against the α‐amylase enzyme (8.42±0.05 μg mL−1). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (−)‐HPLC‐ESI‐MS/MS analysis, were found to contribute to the species′ biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1612-1872 1612-1880 1612-1880
DOI:	10.1002/cbdv.202400680