Search Results - "Borgers, Marianne"

Using Human iPSC-Derived Neurons to Model TAU Aggregation by Verheyen, An, Diels, Annick, Dijkmans, Joyce, Oyelami, Tutu, Meneghello, Giulia, Mertens, Liesbeth, Versweyveld, Sofie, Borgers, Marianne, Buist, Arjan, Peeters, Pieter, Cik, Miroslav

“…Alzheimer's disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal TAU in…”
Get full text

Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice by Janssens, Jonathan, Hermans, Bart, Vandermeeren, Marc, Barale-Thomas, Erio, Borgers, Marianne, Willems, Roland, Meulders, Greet, Wintmolders, Cindy, Van den Bulck, Dries, Bottelbergs, Astrid, Ver Donck, Luc, Larsen, Peter, Moechars, Dieder, Edwards, Wilson, Mercken, Marc, Van Broeck, Bianca

“…The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the…”
Get full text

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau by van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J, Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian

“…Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence…”
Get full text

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities by Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H., Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J. M., Yu, Wenli, Brinkman-van der Linden, Els C., Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J., Wilson, Ian A., Koudstaal, Wouter, Goudsmit, Jaap

“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B…”
Get full text

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease by Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart

“…The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are…”
Get full text

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo by Zhou, Lujia, Barão, Soraia, Laga, Mathias, Bockstael, Katrijn, Borgers, Marianne, Gijsen, Harry, Annaert, Wim, Moechars, Diederik, Mercken, Marc, Gevaer, Kris, De Strooper, Bart

“…Background: The function and physiological substrates of BACE1 remain largely unknown. Results: Novel substrates for BACE1 were identified using large scale…”
Get full text

Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans by Reinhard, Constanze, Borgers, Marianne, David, Guido, De Strooper, Bart

“…Proteolytic processing of amyloid-β precursor protein (APP) generates the amyloid-β peptide, which plays a central role in Alzheimer disease. The physiological…”
Get full text

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity by Hick, Meike, Herrmann, Ulrike, Weyer, Sascha W., Mallm, Jan-Philipp, Tschäpe, Jakob-Andreas, Borgers, Marianne, Mercken, Marc, Roth, Fabian C., Draguhn, Andreas, Slomianka, Lutz, Wolfer, David P., Korte, Martin, Müller, Ulrike C.

“…The key role of APP in the pathogenesis of Alzheimer disease is well established. However, postnatal lethality of double knockout mice has so far precluded the…”
Get full text

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models" by Tesseur, Ina, Lo, Adrian C, Roberfroid, Anouk, Dietvorst, Sofie, Van Broeck, Bianca, Borgers, Marianne, Gijsen, Harrie, Moechars, Diederik, Mercken, Marc, Kemp, John, D'Hooge, Rudi, De Strooper, Bart

“…Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid-lowering drug for Alzheimer's…”
Get full text

Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal Fluid by Rodrigues Martins, Dina, Vandermeeren, Marc, Van Kolen, Kristof, Brepoels, Eddy, Borgers, Marianne, Wintmolders, Cindy, Delay, Charlotte, Bottelbergs, Astrid, Mercken, Marc, Theunis, Clara

“…Clearance of tau seeds by immunization with tau antibodies is currently evaluated as therapeutic strategy to block the spreading of tau pathology in…”
Get more information

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models" by Fitz, Nicholas F, Cronican, Andrea A, Lefterov, Iliya, Koldamova, Radosveta

“…Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer's disease (AD) that treatment of…”
Get full text

Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology by Jacob, Sofia, Davies, Gethin, De Bock, Marijke, Hermans, Bart, Wintmolders, Cindy, Bottelbergs, Astrid, Borgers, Marianne, Theunis, Clara, Van Broeck, Bianca, Manyakov, Nikolay V., Balschun, Detlef, Drinkenburg, Wilhelmus H.I.M.

“…Multiple animal models have been created to gain insight into Alzheimer’s disease (AD) pathology. Among the most commonly used models are transgenic mice…”
Get full text

ANTI-TAU ANTIBODY PROFILING FOR PASSIVE IMMUNIZATION THERAPY: COMPARING SEEDS DERIVED FROM TRANSGENIC ANIMALS AND HUMAN BRAIN TISSUE by Borgers, Marianne, Dockx, Koen, Van de Weyer, Inez, Versweyveld, Sofie, De Waepenaert, Katja, Vandermeeren, Marc, Van Kolen, Kristof, Vanhoof, Greet, Ebneth, Andreas, Mercken, Marc

Get full text

Comment on "ApoE-Directed Therapeutics Rapidly Clear [beta]-Amyloid and Reverse Deficits in AD Mouse Models": 2 by Tesseur, Ina, Lo, Adrian C, Roberfroid, Anouk, Dietvorst, Sofie, Bianca Van Broeck, Borgers, Marianne, Gijsen, Harrie, Moechars, Diederik, Mercken, Marc, Kemp, John, D'Hooge, Rudi, De Strooper, Bart

“…Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid-lowering drug for Alzheimer's…”
Get full text

A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities by Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H, Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J M, Yu, Wenli, Brinkman-van der Linden, Els C, Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J, Wilson, Ian A, Koudstaal, Wouter, Goudsmit, Jaap

“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG memory B…”
Get full text

Erratum to: acute function of secreted amyloid precursor protein fragment APPs[alpha] in synaptic plasticity by Hick, Meike, Herrmann, Ulrike, Weyer, Sascha W, Mallm, Jan-Philipp, Tschape, Jakob-Andreas, Borgers, Marianne, Mercken, Marc, Roth, Fabian C, Draguhn, Andreas, Slomianka, Lutz, Wolfer, David P, Korte, Ma, Muller, Ulrike C

Get full text

Acute function of secreted amyloid precursor protein fragment apps[alpha] in synaptic plasticity by Hick, Meike, Herrmann, Ulrike, Weyer, Sascha W, Mallm, Jan-Philipp, Tschape, Jakob-Andreas, Borgers, Marianne, Mercken, Marc, Roth, Fabian C, Draguhn, Andreas, Slomianka, Lutz, Wolfer, David P, Korte, Ma, Muller, Ulrike C

“…The key role of APP in the pathogenesis of Alzheimer disease is well established. However, postnatal lethality of double knockout mice has so far precluded the…”
Get full text

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo by Zhou, Lujia, Barão, Soraia, Laga, Mathias, Bockstael, Katrijn, Borgers, Marianne, Gijsen, Harry, Annaert, Wim, Moechars, Diederik, Mercken, Marc, Gevaert, Kris, De Strooper, Bart

Get full text

Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity by Hick, Meike, Herrmann, Ulrike, Weyer, Sascha W., Mallm, Jan-Philipp, Tschäpe, Jakob-Andreas, Borgers, Marianne, Mercken, Marc, Roth, Fabian C., Draguhn, Andreas, Slomianka, Lutz, Wolfer, David P., Korte, Martin, Müller, Ulrike C.

Get full text

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser 422 containing epitope on pathological tau by van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J, Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian

“…Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence…”
Get full text