Search Results - "Borg, Holly"

Growth Hormone, Not IGF-1 Is the Key Longevity Regulator in Mammals by Brown-Borg, Holly M

“…There are extraordinary examples of evolutionary conservation in biology, one of which is revealed in aging biology. A robust case in point are three…”
Get full text

Cutting back on the essentials; can manipulating intake of specific amino acids modulate health and lifespan? by Brown-Borg, Holly M, Buffenstein, Rochelle

“…Highlights • In rodent diets, methionine and tryptophan restriction benefit health and lifespan. • Low dietary methionine affects multiple systems including…”
Get full text

Interventions to Slow Aging in Humans: Are We Ready? by Longo, Valter D., Antebi, Adam, Bartke, Andrzej, Barzilai, Nir, Brown‐Borg, Holly M., Caruso, Calogero, Curiel, Tyler J., Cabo, Rafael, Franceschi, Claudio, Gems, David, Ingram, Donald K., Johnson, Thomas E., Kennedy, Brian K., Kenyon, Cynthia, Klein, Samuel, Kopchick, John J., Lepperdinger, Guenter, Madeo, Frank, Mirisola, Mario G., Mitchell, James R., Passarino, Giuseppe, Rudolph, Karl L., Sedivy, John M., Shadel, Gerald S., Sinclair, David A., Spindler, Stephen R., Suh, Yousin, Vijg, Jan, Vinciguerra, Manlio, Fontana, Luigi

“…Summary The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading…”
Get full text

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment by Wang, Tina, Tsui, Brian, Kreisberg, Jason F, Robertson, Neil A, Gross, Andrew M, Yu, Michael Ku, Carter, Hannah, Brown-Borg, Holly M, Adams, Peter D, Ideker, Trey

“…Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease…”
Get full text

“A Glance Back” at the Journals of Gerontology: We’ve Come a Long Way, Baby by Brown-Borg, Holly M

“…Times have changed and science has advanced dramatically since Louis Hellman published on aging and pregnancy outcomes in one of the very first articles in the…”
Get full text

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions by Cole, John J, Robertson, Neil A, Rather, Mohammed Iqbal, Thomson, John P, McBryan, Tony, Sproul, Duncan, Wang, Tina, Brock, Claire, Clark, William, Ideker, Trey, Meehan, Richard R, Miller, Richard A, Brown-Borg, Holly M, Adams, Peter D

“…Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust…”
Get full text

Does Diet Have a Role in the Treatment of Alzheimer's Disease? by Thelen, Mitchell, Brown-Borg, Holly M

“…The aging process causes many changes to the brain and is a major risk factor for the development of neurodegenerative diseases such as Alzheimer's Disease…”
Get full text

The potential role of necroptosis in inflammaging and aging by Royce, Gordon H., Brown-Borg, Holly M., Deepa, Sathyaseelan S.

“…An age-associated increase in chronic, low-grade sterile inflammation termed “inflammaging” is a characteristic feature of mammalian aging that shows a strong…”
Get full text

Bioengineering strategies for augmenting wound-healing efficacy of mesenchymal stem cell-derived extracellular vesicles by Shi, Xianhao, Fu, Nan, Zhang, Huan, Brown-Borg, Holly M., Wang, Shihua, Zhao, Robert Chunhua

Get full text

GH and IGF1: roles in energy metabolism of long-living GH mutant mice by Brown-Borg, Holly M, Bartke, Andrzej

“…Of the multiple theories to explain exceptional longevity, the most robust of these has centered on the reduction of three anabolic protein hormones, growth…”
Get full text

Disentangling High Fat, Low Carb, and Healthy Aging by Brown-Borg, Holly M.

“…Dietary interventions are simple, non-invasive tools that can be utilized to improve health and lifespan. In this issue, Roberts et al. (2017) and Newman…”
Get full text

Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span by Brown-Borg, Holly M.

“…Interventions that improve health are often associated with longevity. Reduced growth hormone signaling has been shown to increase life span in mice by over…”
Get full text

Metabolic adaptation of short‐living growth hormone transgenic mice to methionine restriction and supplementation by Brown‐Borg, Holly M., Rakoczy, Sharlene, Wonderlich, Joseph A., Borg, Kurt E., Rojanathammanee, Lalida

“…Extension of mammalian health and life span has been achieved using various dietary interventions. We previously reported that restricting dietary methionine…”
Get full text

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms by Zhu, Rongjia, Yan, Tingdong, Feng, Yingmei, Liu, Yan, Cao, Hongcui, Peng, Gongxin, Yang, Yanlei, Xu, Zhen, Liu, Jingqi, Hou, Wei, Wang, Xiaoyue, Li, Zhe, Deng, Luchan, Wang, Shihua, Li, Jing, Han, Qin, Li, Hongling, Shan, Guangliang, Cao, Yinghao, An, Xingyan, Yan, Jianshe, Zhang, Zhonghui, Li, Huafei, Qu, Xuebin, Zhu, Jiaqi, Zhou, Shumin, Wang, Jiao, Zhang, Fengchun, Gao, Jinming, Jin, Ronghua, Xu, Dayong, Ma, Yan-Qing, Huang, Tao, Peng, Shuang, Zheng, Zhi, Stambler, Ilia, Gilson, Eric, Lim, Lee Wei, Moskalev, Alexey, Cano, Antonio, Chakrabarti, Sasanka, Ulfhake, Brun, Su, Huanxing, Xu, Haoying, Xu, Sihuan, Wei, Feng, Brown-Borg, Holly M., Min, Kyung-Jin, Ellison-Hughes, Georgina, Caruso, Calogero, Jin, Kunlin, Zhao, Robert Chunhua

“…The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying…”
Get full text

Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice by Buffenstein, Rochelle, Lewis, Kaitlyn N, Gibney, Patrick A, Narayan, Vikram, Grimes, Kelly M, Smith, Megan, Lin, Tzuhua D, Brown-Borg, Holly M

“…Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in extraordinarily long-lived naked mole-rats. Many of these traits (e.g., slow…”
Get full text

Growth hormone signaling is necessary for lifespan extension by dietary methionine by Brown‐Borg, Holly M., Rakoczy, Sharlene G., Wonderlich, Joseph A., Rojanathammanee, Lalida, Kopchick, John J., Armstrong, Vanessa, Raasakka, Debbie

“…Summary Growth hormone significantly impacts lifespan in mammals. Mouse longevity is extended when growth hormone (GH) signaling is interrupted but markedly…”
Get full text

Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle by Romanick, Mark, Thompson, LaDora V., Brown-Borg, Holly M.

“…With the extension of life span over the past several decades, the age-related loss of muscle mass and strength that characterizes sarcopenia is becoming more…”
Get full text

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells by Shavali, Shaik, Brown-Borg, Holly M., Ebadi, Manuchair, Porter, James

“…Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication…”
Get full text

Hormonal control of aging in rodents: The somatotropic axis by Brown-Borg, Holly M.

“…There is a growing body of literature focusing on the somatotropic axis and regulation of aging and longevity. Many of these reports derive data from multiple…”
Get full text

Metabolic adventures in aging research by Brown-Borg, Holly M., Anderson, Rozalyn M.

Get full text