Search Results - "Borenstein, T"

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function by Bettinger, Christopher J, Langer, Robert, Borenstein, Jeffrey T

“…The interaction of mammalian cells with nanoscale topography has proven to be an important signaling modality in controlling cell function. Naturally occurring…”
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Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions by Bale, Shyam Sundhar, Borenstein, Jeffrey T

“…Animal models such as rats and primates provide body-wide information for drug and metabolite responses, including organ-specific toxicity and any unforeseen…”
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Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks by Yesilyurt, Volkan, Ayoob, Andrew M., Appel, Eric A., Borenstein, Jeffrey T., Langer, Robert, Anderson, Daniel G.

“…Hydrogels play a central role in a number of medical applications and new research aims to engineer their mechanical properties to improve their capacity to…”
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Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering by Bettinger, Christopher J, Bruggeman, Joost P, Misra, Asish, Borenstein, Jeffrey T, Langer, Robert

“…Abstract The advancement of tissue engineering is contingent upon the development and implementation of advanced biomaterials. Conductive polymers have…”
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Accordion-like honeycombs for tissue engineering of cardiac anisotropy by Freed, Lisa E, Engelmayr, George C, Cheng, Mingyu, Bettinger, Christopher J, Borenstein, Jeffrey T, Langer, Robert

“…Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds have been structurally incompatible with recapitulating cardiac…”
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Three-Dimensional Microfluidic Tissue-Engineering Scaffolds Using a Flexible Biodegradable Polymer by Bettinger, C. J., Weinberg, E. J., Kulig, K. M., Vacanti, J. P., Wang, Y., Borenstein, J. T., Langer, R.

“…Three‐dimensional microfluidic networks using a flexible biodegradable polymer have been fabricated using modified microfabrication processes tailored…”
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The effect of actin disrupting agents on contact guidance of human embryonic stem cells by Gerecht, Sharon, Bettinger, Christopher J, Zhang, Zhitong, Borenstein, Jeffrey T, Vunjak-Novakovic, Gordana, Langer, Robert

“…Abstract Mammalian cells respond to their substrates by complex changes in gene expression profiles, morphology, proliferation and migration. We report that…”
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Advanced Material Strategies for Tissue Engineering Scaffolds by Freed, Lisa E., Engelmayr Jr, George C., Borenstein, Jeffrey T., Moutos, Franklin T., Guilak, Farshid

“…Tissue engineering seeks to restore the function of diseased or damaged tissues through the use of cells and biomaterial scaffolds. It is now apparent that the…”
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High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro by Gard, A. L., Luu, R. J., Miller, C. R., Maloney, R., Cain, B. P., Marr, E. E., Burns, D. M., Gaibler, R., Mulhern, T. J., Wong, C. A., Alladina, J., Coppeta, J. R., Liu, P., Wang, J. P., Azizgolshani, H., Fezzie, R. Fennell, Balestrini, J. L., Isenberg, B. C., Medoff, B. D., Finberg, R. W., Borenstein, J. T.

“…Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence…”
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A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions by Rogers, Miles T., Gard, Ashley L., Gaibler, Robert, Mulhern, Thomas J., Strelnikov, Rivka, Azizgolshani, Hesham, Cain, Brian P., Isenberg, Brett C., Haroutunian, Nerses J., Raustad, Nicole E., Keegan, Philip M., Lech, Matthew P., Tomlinson, Lindsay, Borenstein, Jeffrey T., Charest, Joseph L., Williams, Corin

“…Microphysiological organ-on-chip models offer the potential to improve the prediction of drug safety and efficacy through recapitulation of human physiological…”
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Silk Fibroin Microfluidic Devices by Bettinger, C. J., Cyr, K. M., Matsumoto, A., Langer, R., Borenstein, J. T., Kaplan, D. L.

“…Microfluidic devices were fabricated from silk fibroin using an aqueous molding process adapted from soft lithography. The process results in mechanically…”
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Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography by Bettinger, C. J., Zhang, Z., Gerecht, S., Borenstein, J. T., Langer, R.

“…Endothelial progenitor cells are cultured on nanotopographic substrates with a line‐grating geometry and respond to these substrates through aligned and…”
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Toward microfluidic integration of respiratory and renal organ support in a single cartridge by Setty, A A, Chiang, T, Santos, J A, Isenberg, B C, Vedula, E, Keating, R, Sutherland, D W, Borenstein, J T

“…Extracorporeal organ assist devices provide lifesaving functions for acutely and chronically ill patients suffering from respiratory and renal failure, but…”
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Rapid generation of spatially and temporally controllable long-range concentration gradients in a microfluidic device by Du, Yanan, Shim, Jaesool, Vidula, Mahesh, Hancock, Matthew J, Lo, Edward, Chung, Bong Geun, Borenstein, Jeffrey T, Khabiry, Masoud, Cropek, Donald M, Khademhosseini, Ali

“…The ability to rapidly generate concentration gradients of diffusible molecules has important applications in many chemical and biological studies. Here we…”
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Amino alcohol-based degradable poly(ester amide) elastomers by Bettinger, Christopher J, Bruggeman, Joost P, Borenstein, Jeffrey T, Langer, Robert S

“…Abstract Currently available synthetic biodegradable elastomers are primarily composed of crosslinked aliphatic polyesters, which suffer from deficiencies…”
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Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment by Doty, Daniel T, Schueler, Julia, Mott, Vienna L, Bryan, Cassie M, Moore, Nathan F, Ho, John C, Borenstein, Jeffrey T

“…The immune checkpoint blockade represents a revolution in cancer therapy, with the potential to increase survival for many patients for whom current treatments…”
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Development of a biomimetic microfluidic oxygen transfer device by Gimbel, A A, Flores, E, Koo, A, García-Cardeña, G, Borenstein, J T

“…Blood oxygenators provide crucial life support for patients suffering from respiratory failure, but their use is severely limited by the complex nature of the…”
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A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery by Gard, Ashley L., Luu, Rebeccah J., Maloney, Ryan, Cooper, Madeline H., Cain, Brian P., Azizgolshani, Hesham, Isenberg, Brett C., Borenstein, Jeffrey T., Ong, Jane, Charest, Joseph L., Vedula, Else M.

“…Nearly half of American adults suffer from gum disease, including mild inflammation of gingival tissue, known as gingivitis. Currently, advances in therapeutic…”
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Microfabrication Technology for Vascularized Tissue Engineering by Borenstein, Jeffrey T, Terai, H, King, Kevin R, Weinberg, E J, Kaazempur-Mofrad, M R, Vacanti, J P

“…This work describes the application of advanced microfabrication technologies including silicon micromachining and polymer replica molding towards the field of…”
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3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids by Markoski, Alex, Wong, Ian Y, Borenstein, Jeffrey T

“…Microfluidic systems for the analysis of tissue models of cancer and other diseases are rapidly emerging, with an increasing recognition that perfusion is…”
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