Relationship between hyponatremia at hospital admission and cardiopulmonary profile at follow-up in patients with SARS-CoV-2 (COVID-19) infection

Relationship between hyponatremia at hospital admission and cardiopulmonary profile at follow-up in patients with SARS-CoV-2 (COVID-19) infection

Purpose Hyponatremia occurs in about 30% of patients with pneumonia, including those with SARS-CoV-2 (COVID-19) infection. Hyponatremia predicts a worse outcome in several pathologic conditions and in COVID-19 has been associated with a higher risk of non-invasive ventilation, ICU transfer and death...

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Bibliographic Details
Published in:Journal of endocrinological investigation Vol. 46; no. 3; pp. 577 - 586
Main Authors: Malandrino, D., Berni, A., Fibbi, B., Borellini, B., Cozzi, D., Norello, D., Fattirolli, F., Lavorini, F., Olivotto, I., Fumagalli, C., Zocchi, C., Tassetti, L., Gozzi, L., Marchionni, N., Maggi, M., Peri, A.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-03-2023
Springer Nature B.V
Subjects:
Calcium-binding protein
Complications
Coronaviruses
COVID-19
COVID-19 - complications
Echocardiography
Endocrinology
Fibrinogen
Follow-Up Studies
Heart
Hospitals
Humans
Hyponatremia
Hyponatremia - complications
Interleukin 6
Internal Medicine
Laboratories
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Respiratory Sounds
Retrospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Troponin
Troponin T
Ventricle
Pneumonia
Hyponatremia
SARS-CoV-2 (COVID-19) infection
Outcome
SIAD
Follow-up
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Summary:Purpose Hyponatremia occurs in about 30% of patients with pneumonia, including those with SARS-CoV-2 (COVID-19) infection. Hyponatremia predicts a worse outcome in several pathologic conditions and in COVID-19 has been associated with a higher risk of non-invasive ventilation, ICU transfer and death. The main objective of this study was to determine whether early hyponatremia is also a predictor of long-term sequelae at follow-up. Methods In this observational study, we collected 6-month follow-up data from 189 laboratory-confirmed COVID-19 patients previously admitted to a University Hospital. About 25% of the patients ( n  = 47) had hyponatremia at the time of hospital admission. Results Serum [Na + ] was significantly increased in the whole group of 189 patients at 6 months, compared to the value at hospital admission (141.4 ± 2.2 vs 137 ± 3.5 mEq/L, p  < 0.001). In addition, IL-6 levels decreased and the PaO 2 /FiO 2 increased. Accordingly, pulmonary involvement, evaluated at the chest X-ray by the RALE score, decreased. However, in patients with hyponatremia at hospital admission, higher levels of LDH, fibrinogen, troponin T and NT-ProBNP were detected at follow-up, compared to patients with normonatremia at admission. In addition, hyponatremia at admission was associated with worse echocardiography parameters related to right ventricular function, together with a higher RALE score. Conclusion These results suggest that early hyponatremia in COVID-19 patients is associated with the presence of laboratory and imaging parameters indicating a greater pulmonary and right-sided heart involvement at follow-up.
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ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-022-01938-9