Search Results - "Borell, Hubert"

Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism by Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, van Marle, Sjoerd Peter, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne

“…Siponimod, a next-generation selective sphingosine-1-phosphate receptor modulator, is currently being investigated for the treatment of secondary progressive…”
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CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis by YI JIN, ZOLLINGER, Markus, BORELL, Hubert, ZIMMERLIN, Alfred, PATTEN, Christopher J

“…Fingolimod (FTY720, Gilenya, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol) is a novel drug recently approved in the United States for the oral treatment…”
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An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data by James, Alexander D., Schiller, Hilmar, Marvalin, Cyrille, Jin, Yi, Borell, Hubert, Roffel, Ad F., Glaenzel, Ulrike, Ji, Yan, Camenisch, Gian

“…Ribociclib (LEE011, Kisqali ®) is a highly selective small molecule inhibitor of cyclin‐dependent kinases 4 and 6 (CDK4/6), which has been approved for the…”
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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite by Glaenzel, Ulrike, Jin, Yi, Hansen, Regine, Schroer, Kirsten, Rahmanzadeh, Gholamreza, Pfaar, Ulrike, Jaap van Lier, Jan, Borell, Hubert, Meissner, Axel, Camenisch, Gian, Zhao, Sylvia

“…Capmatinib (INC280), a highly selective and potent inhibitor of the MET receptor tyrosine kinase, has demonstrated clinically meaningful efficacy and a…”
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In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics by Jin, Yi, Borell, Hubert, Gardin, Anne, Ufer, Mike, Huth, Felix, Camenisch, Gian

“…Purpose The purpose of the study is to investigate the enzyme(s) responsible for siponimod metabolism and to predict the inhibitory effects of fluconazole as…”
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Metabolism and Disposition of Siponimod, a Novel Selective S1P 1 /S1P 5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism by Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, Peter van Marle, Sjoerd, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne

“…Siponimod, a next-generation selective sphingosine-1-phosphate receptor modulator, is currently being investigated for the treatment of secondary progressive…”
Get full text