Search Results - "Borel, Franck"

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives by Jobelius, Hannah, Bianchino, Gabriella Ines, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms…”
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Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling by Labar, Geoffray, Bauvois, Cédric, Borel, Franck, Ferrer, Jean-Luc, Wouters, Johan, Lambert, Didier M.

“…2‐Arachidonoylglycerol plays a major role in endocannabinoid signaling, and is tightly regulated by the monoacylglycerol lipase (MAGL). Here we report the…”
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Rational design of a monomeric and photostable far‐red fluorescent protein for fluorescence imaging in vivo by Yu, Dan, Dong, Zhiqiang, Gustafson, William Clay, Ruiz‐González, Rubén, Signor, Luca, Marzocca, Fanny, Borel, Franck, Klassen, Matthew P., Makhijani, Kalpana, Royant, Antoine, Jan, Yuh‐Nung, Weiss, William A., Guo, Su, Shu, Xiaokun

“…Fluorescent proteins (FPs) are powerful tools for cell and molecular biology. Here based on structural analysis, a blue‐shifted mutant of a recently engineered…”
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Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein by Duarte, Victor, Latour, Jean-Marc, Traoré, Daouda A K, Ghazouani, Abdelnasser El, Jacquamet, Lilian, Borel, Franck, Ferrer, Jean-Luc, Lascoux, David, Ravanat, Jean-Luc, Jaquinod, Michel, Blondin, Geneviève, Caux-Thang, Christelle

“…In Bacillus subtilis , PerR is a metal-dependent sensor of hydrogen peroxide. PerR is a dimeric zinc protein with a regulatory site that coordinates either Fe…”
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Multiple Centrosomes Arise from Tetraploidy Checkpoint Failure and Mitotic Centrosome Clusters in p53 and RB Pocket Protein-Compromised Cells by Borel, Franck, Lohez, Olivier D., Lacroix, Françoise B., Margolis, Robert L.

“…A high degree of aneuploidy characterizes the majority of human tumors. Aneuploid status can arise through mitotic or cleavage failure coupled with failure of…”
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Crystal Structure of the Cold-active Aminopeptidase from Colwellia psychrerythraea, a Close Structural Homologue of the Human Bifunctional Leukotriene A4 Hydrolase by Bauvois, Cédric, Jacquamet, Lilian, Huston, Adrienne L., Borel, Franck, Feller, Georges, Ferrer, Jean-Luc

“…The crystal structure of a cold-active aminopeptidase (ColAP) from Colwellia psychrerythraea strain 34H has been determined, extending the number of crystal…”
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DHR51, the Drosophila melanogaster Homologue of the Human Photoreceptor Cell-Specific Nuclear Receptor, Is a Thiolate Heme-Binding Protein by de Rosny, Eve, de Groot, Arjan, Jullian-Binard, Celine, Borel, Franck, Suarez, Cristian, Le Pape, Laurent, Fontecilla-Camps, Juan C, Jouve, Hélène M

“…Heme has been recently described as a regulating ligand for the activity of the human nuclear receptors (NR) REV-ERBα and REV-ERBβ and their Drosophila…”
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Drosophila Nuclear Receptor E75 Is a Thiolate Hemoprotein by de Rosny, Eve, de Groot, Arjan, Jullian-Binard, Celine, Gaillard, Jacques, Borel, Franck, Pebay-Peyroula, Eva, Fontecilla-Camps, Juan Carlos, Jouve, Hélène M

“…Drosophila E75 is a member of the nuclear receptor superfamily. These eukaryotic transcription factors are involved in almost all physiological processes. They…”
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Structural Basis for the Modulation of CDK-Dependent/Independent Activity of Cyclin D1 by Ferrer, Jean-Luc, Dupuy, Jerome, Borel, Franck, Jacquamet, Lilian, Noel, Joseph P., Dulic, Vjekoslav

“…D-type cyclins are key regulators of the cell division cycle. In association with Cyclin Dependent Kinases (CDK) 2/4/6, they control the G1/S-phase transition…”
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A microfluidic device for both on-chip dialysis protein crystallization and in situ X-ray diffraction by Junius, Niels, Jaho, Sofia, Sallaz-Damaz, Yoann, Borel, Franck, Salmon, Jean-Baptiste, Budayova-Spano, Monika

“…This paper reports a versatile microfluidic chip developed for on-chip crystallization of proteins through the dialysis method and in situ X-ray diffraction…”
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The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives by Jobelius, Hannah, Bianchino, Gabriella, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms…”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…Our previous research revealed that (E)-4-amino-3-methylbut-2-en-1-yl diphosphate (AMBPP) is one of the best inhibitors of IspH, a [4Fe-4S]-dependent enzyme…”
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Magnetostrictive energy conversion ability of Iron Cobalt Vanadium alloy sheet: Experimental and theoretical evaluation by Zangho, Borel Franck Toutsop, Liu, Yuanyuan, Zhang, Shurui, Lallart, Mickaël, Morel, Laurent, Sebald, Gael, Tsafack, Pierre, Ducharne, Benjamin

“…The increasing demand for autonomous devices has made the concept of energy harvesting a significant industrial and academic point of interest. In this domain,…”
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Magnetostrictive energy conversion ability of Iron Cobalt Vanadium alloy sheet: Experimental and theoretical evaluation by Zangho, Borel Franck Toutsop, Liu, Yuanyuan, Zhang, Shurui, Lallart, Mickaël, Morel, Laurent, Sebald, Gael, Tsafack, Pierre, Ducharne, Benjamin

“…The increasing demand for autonomous devices has made the concept of energy harvesting a significant industrial and academic point of interest. In this domain,…”
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Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022) by Herrscher, Vivien, Witjaksono, Clea, Buchotte, Marie, Ferret, Claire, Massicot, Fabien, Vasse, Jean‐Luc, Borel, Franck, Behr, Jean‐Bernard, Seemann, Myriam

“…The rational design of a substrate analogue has afforded the first irreversible inhibitor of an IspG enzyme, a target for the development of new drugs to fight…”
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Synthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD by Baatarkhuu, Zoljargal, Chaignon, Philippe, Borel, Franck, Ferrer, Jean-Luc, Wagner, Alain, Seemann, Myriam

“…As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the…”
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Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate by Herrscher, Vivien, Witjaksono, Clea, Buchotte, Marie, Ferret, Claire, Massicot, Fabien, Vasse, Jean‐Luc, Borel, Franck, Behr, Jean‐Bernard, Seemann, Myriam

“…IspG (also called GcpE) is an oxygen‐sensitive [4Fe‐4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated…”
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Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease by Borel, Franck, Marzocca, Fanny, Delcros, Jean-Guy, Rama, Nicolas, Mehlen, Patrick, Ferrer, Jean-Luc

“…Alzheimer's disease is a growing concern in the context of the increasing lifespan of the populations. The work presented here is part of the fight against…”
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Crystal structure of mouse mu‐crystallin complexed with NADPH and the T3 thyroid hormone by Borel, Franck, Hachi, Isma, Palencia, Andres, Gaillard, Marie‐Claude, Ferrer, Jean‐Luc

“…Mu‐crystallin (CRYM), first described as a structural component of the eye lens in marsupials, has been characterized as an NADPH‐dependent cytosolic T3…”
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Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials by Borel, Franck, Barbier, Elodie, Krasutsky, Sergiy, Janthawornpong, Karnjapan, Chaignon, Philippe, Poulter, C. Dale, Ferrer, Jean‐Luc, Seemann, Myriam

“…IspH, also called LytB, a protein involved in the biosynthesis of isoprenoids through the methylerythritol phosphate pathway, is an attractive target for the…”
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