Search Results - "Borek, Dominika M."

Crystal structure of the human sterol transporter ABCG5/ABCG8 by Lee, Jyh-Yeuan, Kinch, Lisa N., Borek, Dominika M., Wang, Jin, Wang, Junmei, Urbatsch, Ina L., Xie, Xiao-Song, Grishin, Nikolai V., Cohen, Jonathan C., Otwinowski, Zbyszek, Hobbs, Helen H., Rosenbaum, Daniel M.

“…The X-ray structure of human ABCG5/ABCG8 heterodimer in a nucleotide-free state, being the first atomic model of an ABC sterol transporter. Human ABCG5/ABCG8…”
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Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1 by Xu, Wei, Edwards, Megan R., Borek, Dominika M., Feagins, Alicia R., Mittal, Anuradha, Alinger, Joshua B., Berry, Kayla N., Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J., Pappu, Rohit V., Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

“…During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs via a subset of…”
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Structural basis for Marburg virus VP35–mediated immune evasion mechanisms by Ramanan, Parameshwaran, Edwards, Megan R, Shabman, Reed S, Leung, Daisy W, Endlich-Frazier, Ariel C, Borek, Dominika M, Otwinowski, Zbyszek, Liu, Gai, Huh, Juyoung, Basler, Christopher F, Amarasinghe, Gaya K

“…Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative agents of highly lethal hemorrhagic fever in humans. MARV and EBOV share a common genome…”
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Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35 by Amarasinghe, Gaya K, Leung, Daisy W, Prins, Kathleen C, Borek, Dominika M, Farahbakhsh, Mina, Tufariello, JoAnn M, Ramanan, Parameshwaran, Nix, Jay C, Helgeson, Luke A, Otwinowski, Zbyszek, Honzatko, Richard B, Basler, Christopher F

“…The protein VP35 from Ebola virus contributes to immune evasion by antagonizing interferon signaling pathways. Now the crystal structure of the interferon…”
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Structure of the human cohesin inhibitor Wapl by Ouyang, Zhuqing, Zheng, Ge, Song, Jianhua, Borek, Dominika M., Otwinowski, Zbyszek, Brautigam, Chad A., Tomchick, Diana R., Rankin, Susannah, Yu, Hongtao

“…Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a…”
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In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity by Brown, Craig S., Lee, Michael S., Leung, Daisy W., Wang, Tianjiao, Xu, Wei, Luthra, Priya, Anantpadma, Manu, Shabman, Reed S., Melito, Lisa M., MacMillan, Karen S., Borek, Dominika M., Otwinowski, Zbyszek, Ramanan, Parameshwaran, Stubbs, Alisha J., Peterson, Dayna S., Binning, Jennifer M., Tonelli, Marco, Olson, Mark A., Davey, Robert A., Ready, Joseph M., Basler, Christopher F., Amarasinghe, Gaya K.

“…The Ebola virus (EBOV) genome only encodes a single viral polypeptide with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein…”
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Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain by Leung, Daisy W., Shabman, Reed S., Farahbakhsh, Mina, Prins, Kathleen C., Borek, Dominika M., Wang, Tianjiao, Mühlberger, Elke, Basler, Christopher F., Amarasinghe, Gaya K.

“…Ebolaviruses are causative agents of lethal hemorrhagic fever in humans and nonhuman primates. Among the filoviruses characterized thus far, Reston Ebola virus…”
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Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy by Kikuchi, Sotaro, Borek, Dominika M., Otwinowski, Zbyszek, Tomchick, Diana R., Yu, Hongtao

“…The ring-shaped cohesin complex topologically entraps chromosomes and regulates chromosome segregation, transcription, and DNA repair. The cohesin core…”
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Development of RNA Aptamers Targeting Ebola Virus VP35 by Binning, Jennifer M, Wang, Tianjiao, Luthra, Priya, Shabman, Reed S, Borek, Dominika M, Liu, Gai, Xu, Wei, Leung, Daisy W, Basler, Christopher F, Amarasinghe, Gaya K

“…Viral protein 35 (VP35), encoded by filoviruses, is a multifunctional dsRNA binding protein that plays important roles in viral replication, innate immune…”
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Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses by Chatterjee, Srirupa, Luthra, Priya, Esaulova, Ekaterina, Agapov, Eugene, Yen, Benjamin C., Borek, Dominika M., Edwards, Megan R., Mittal, Anuradha, Jordan, David S., Ramanan, Parameshwar, Moore, Martin L., Pappu, Rohit V., Holtzman, Michael J., Artyomov, Maxim N., Basler, Christopher F., Amarasinghe, Gaya K., Leung, Daisy W.

“…Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations 1 , 2 . A…”
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An intrinsically disordered peptide from Ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions by Leung, Daisy W., Borek, Dominika M., Luthra, Priya, Binning, Jennifer M., Anantpadma, Manu, Liu, Gai, Harvey, Ian B., Su, Zhaoming, Endlich-Frazier, Ariel, Pan, Juanli, Shabman, Reed S., Chiu, Wah, Davey, Robert, Otwinowski, Zbyszek, Basler, Christopher F., Amarasinghe, Gaya K.

“…During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA template-bound form and a template-free form to provide the viral…”
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Taking a look at the calibration of a CCD detector with a fiber-optic taper by Alkire, R. W., Rotella, F. J., Duke, N. E. C., Otwinowski, Zbyszek, Borek, Dominika

“…At the Structural Biology Center beamline 19BM, located at the Advanced Photon Source, the operational characteristics of the equipment are routinely checked…”
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Ebola virus VP24 targets a unique NLS-binding site on karyopherin5 to selectively compete with nuclear import of phosphorylated STAT1 by Xu, Wei, Edwards, Megan R., Borek, Dominika M., Feagins, Alicia R., Mittal, Anuradha, Alinger, Joshua B., Berry, Kayla N., Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J., Pappu, Rohit V., Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

“…During anti-viral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine phosphorylated STAT1 (PY-STAT1), which occurs via a subset of…”
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Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1 by Xu, Wei, Edwards, Megan R., Borek, Dominika M., Feagins, Alicia R., Mittal, Anuradha, Alinger, Joshua B., Berry, Kayla N., Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J., Pappu, Rohit V., Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

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In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase co-factor activity by Brown, Craig S., Lee, Michael S., Leung, Daisy W., Wang, Tianjiao, Xu, Wei, Luthra, Priya, Anantpadma, Manu, Shabman, Reed S., Melito, Lisa M., MacMillan, Karen S., Borek, Dominika M., Otwinowski, Zbyszek, Ramanan, Parameshwaran, Stubbs, Alisha J., Peterson, Dayna S., Binning, Jennifer M., Tonelli, Marco, Olson, Mark A., Davey, Rob, Ready, Joseph M., Basler, Christopher F., Amarasinghe, Gaya K.

“…The Ebola virus (EBOV) genome only encodes a single viral polypeptide with enzymatic activity, the viral Large (L) RNA-dependent RNA polymerase protein…”
Get full text

Structural and functional characterization of Reston Ebola VP35 Interferon Inhibitory Domain by Leung, Daisy W., Shabman, Reed S., Farahbakhsh, Mina, Prins, Kathleen C., Borek, Dominika M., Wang, Tianjiao, Mühlberger, Elke, Basler, Christopher F., Amarasinghe, Gaya K.

“…Ebola viruses (EBOV) are causative agents of lethal hemorrhagic fever in humans and non-human primates. Among the filoviruses characterized thus far, Reston…”
Get full text