Search Results - "Borden, E.C."

P061 SHP-1 inhibitors to enhance signaling and IFN-Γ production by activated T cells, mediate antitumor effects of through IFN-g, and to augment blockade of CTLA-4 by ipilimumab by Borden, E.C., Yi, T., Lindner, D.

“…The Src homology region 2 domain-containing phosphatase 1 (SHP-1) is a key negative regulator of signal transduction in response to cytokines, such as IL-2 and…”
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9404 ORAL Long-term Survival on S0033 – a Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate at Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumours (GISTs) by Blanke, C, Rankin, C, Benjamin, R.S, Raymond, A.K, Heinrich, M.C, Fletcher, C.D.M, Crowley, J, Borden, E.C, Demetri, G.D, Baker, L.H

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G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer by Cheriyath, V, Kuhns, M A, Jacobs, B S, Evangelista, P, Elson, P, Downs-Kelly, E, Tubbs, R, Borden, E C

“…Hormonally regulated survival factors can have an important role in breast cancer. Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as…”
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A Notch1–neuregulin1 autocrine signaling loop contributes to melanoma growth by Zhang, K, Wong, P, Zhang, L, Jacobs, B, Borden, E C, Aster, J C, Bedogni, B

“…The Notch pathway is an evolutionary conserved signaling cascade that has an essential role in melanoblast and melanocyte stem cell homeostasis. Notch…”
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Modulation of interferon (IFN)-inducible gene expression by retinoic acid. Up-regulation of STAT1 protein in IFN-unresponsive cells by Kolla, V, Lindner, D J, Xiao, W, Borden, E C, Kalvakolanu, D V

“…Interferons (IFN) and retinoids failed to inhibit the growth of a number of breast tumor cell lines. However, a combination of these two biological response…”
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623 Gene expression enhancement by inhibitors of methylation: potential role in augmentation of apoptosis induced by interferons (IFNs) in melanoma and renal cell carcinoma (RCC) by Borden, E.C., Rue, F.J., Fox, M.W., Beaulieu, N., Leaman, D.W., MacLeod, A.R.

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Effects of interferon beta ser and transforming growth factor beta on prostatic cell lines by Goldstein, D, O'Leary, M, Mitchen, J, Borden, E C, Wilding, G

“…The effect of interferon beta ser (IFN beta ser) on the growth of three prostatic cancer cell lines DU-145, PC-3 and LNCaP was studied. IFN beta ser inhibited…”
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Effects of interferons in neoplastic diseases of man by Borden, E C

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Antiproliferative activities of interferons against human bladder carcinoma cell lines in vitro by Borden, E C, Groveman, D S, Nasu, T, Reznikoff, C, Bryan, G T

“…The antiproliferative effect of interferons against 5 human bladder carcinoma cell lines, RT112, T24, RT4, 647V and HT1197, was determined in vitro. Each of…”
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Effects of cytokines on the pituitary-adrenal axis in cancer patients by Nolten, W E, Goldstein, D, Lindstrom, M, McKenna, M V, Carlson, I H, Trump, D L, Schiller, J, Borden, E C, Ehrlich, E N

“…Cytokines, which include interferons (IFNs), interleukins (ILs), and tumor necrosis factor (TNF), are immunoregulatory proteins produced by lymphocytes and…”
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Isoforms p69 and p100 of 2',5'-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro by Witt, P L, Marié, I, Robert, N, Irizarry, A, Borden, E C, Hovanessian, A G

“…Four isoforms of 2',5'-oligoadenylate (2-5A) synthetase have been identified (40, 44, 69, and 100 kD). The 40- and 44-kD enzymes are encoded by the same gene,…”
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Absence of biological effects of orally administered interferon-beta ser by Witt, P L, Goldstein, D, Storer, B E, Grossberg, S E, Flashner, M, Colby, C B, Borden, E C

“…To assess biological effectiveness of interferon (IFN) administered orally, we measured serum IFN and several proteins and metabolites induced by IFN after…”
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Applications of monoclonal antibodies and recombinant cytokines for the treatment of human colorectal and other carcinomas by Greiner, J W, Smalley, R V, Borden, E C, Martin, E W, Guadagni, F, Roselli, M, Schlom, J

“…Monoclonal antibodies (MAbs) which recognize a human tumor antigen, termed tumor-associated glycoprotein-72 (TAG-72), have successfully been used to localize…”
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Measurement of 2',5'-oligoadenylate synthetase in patients receiving interferon-alpha by Merritt, J A, Borden, E C, Ball, L A

“…The interferon-induced intracellular enzyme, 2',5'-oligoadenylate (2,5A) synthetase, was measured in extracts of Ficoll-purified human peripheral mononuclear…”
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Radiosensitization of human bronchogenic carcinoma cells by interferon beta by Gould, M N, Kakria, R C, Olson, S, Borden, E C

“…The effects of interferons on the radiosensitivity of in vitro human bronchogenic carcinoma cells was investigated. Human fibroblast-derived interferon…”
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Immunologic function during adjuvant BCG immunotherapy for malignant melanoma: Induction of anergy by Coates, A.S., Klopp, R.G., Zarling, J.M., Borden, E.C., Crowley, J.J., Carbone, P.P.

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Influence of non-specific immunologic factors on prognosis in advanced bronchogenic carcinoma by Liberati, A M, Voelkel, J G, Borden, E C, Coates, A S, Citrin, D L, Bryan, G T

“…Fifty-nine evaluable patients with stage III bronchogenic carcinoma, participating in a randomized clinical trial evaluating the effect of adjuvant…”
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A Cardiovascular Model For The Optimization Of Closed Loop Therapy by Woodruff, E.A., Martin, J.F., Borden, E.C.

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