Search Results - "Borchert, Glen M"
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An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression
Published in American journal of physiology. Lung cellular and molecular physiology (01-12-2015)“…In hypoxia, mitochondria-generated reactive oxygen species not only stimulate accumulation of the transcriptional regulator of hypoxic gene expression, hypoxia…”
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Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia
Published in Frontiers in immunology (14-06-2022)“…Cigarette smoke (CS) exposure is strongly associated with chronic obstructive pulmonary disease (COPD). In respiratory airways, CS exposure disrupts airway…”
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Development of a support vector machine learning and smart phone Internet of Things-based architecture for real-time sleep apnea diagnosis
Published in BMC medical informatics and decision making (15-12-2020)“…The breathing disorder obstructive sleep apnea syndrome (OSAS) only occurs while asleep. While polysomnography (PSG) represents the premiere standard for…”
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A partial encryption algorithm for medical images based on quick response code and reversible data hiding technology
Published in BMC medical informatics and decision making (15-12-2020)“…Medical image data, like most patient information, have a strong requirement for privacy and confidentiality. This makes transmitting medical image data,…”
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Muscle fatigue detection and treatment system driven by internet of things
Published in BMC medical informatics and decision making (23-12-2019)“…Internet of things is fast becoming the norm in everyday life, and integrating the Internet into medical treatment, which is increasing day by day, is of high…”
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Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype
Published in iScience (19-08-2022)“…Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in…”
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A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia
Published in BMC medical informatics and decision making (23-07-2018)“…Acute lymphoblastic leukemia is the most prevalent neoplasia among children. Despite the tremendous achievements of state-of-the-art treatment strategies, drug…”
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OMIT: dynamic, semi-automated ontology development for the microRNA domain
Published in PloS one (15-07-2014)“…As a special class of short non-coding RNAs, microRNAs (a.k.a. miRNAs or miRs) have been reported to perform important roles in various biological processes by…”
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Repression of human activation induced cytidine deaminase by miR-93 and miR-155
Published in BMC cancer (10-08-2011)“…Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis…”
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Using an artificial neural network to map cancer common data elements to the biomedical research integrated domain group model in a semi-automated manner
Published in BMC medical informatics and decision making (23-12-2019)“…The medical community uses a variety of data standards for both clinical and research reporting needs. ISO 11179 Common Data Elements (CDEs) represent one such…”
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Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
Published in NPJ breast cancer (10-07-2017)“…Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined…”
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RNA polymerase III transcribes human microRNAs
Published in Nature structural & molecular biology (01-12-2006)“…Prior work demonstrates that mammalian microRNA (miRNA or miR) expression requires RNA polymerase II (Pol II). However, the transcriptional requirements of…”
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Exploring Observability of Attractor Cycles in Boolean Networks for Biomarker Detection
Published in IEEE access (2019)“…Boolean Network (BN) is a simple and popular mathematical model that has attracted significant attention from systems biology due to its capacity to reveal…”
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Characterization of 475 Novel, Putative Small RNAs (sRNAs) in Carbon-Starved Salmonella enterica Serovar Typhimurium
Published in Antibiotics (Basel) (16-03-2021)“…An increasingly apparent role of noncoding RNA (ncRNAs) is to coordinate gene expression during environmental stress. A mounting body of evidence implicates…”
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MicroRNA Expression: Protein Participants in MicroRNA Regulation
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…MiRNAs are ~20 nt small RNAs that regulate networks of proteins using a seed region of nucleotides 2-8 to complement the 3' UTR of target mRNAs. The biogenesis…”
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Histone H2A and H2B are monoubiquitinated at AID-targeted loci
Published in PloS one (16-07-2010)“…Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway…”
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Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…As masters of genome-wide regulation, miRNAs represent a key component in the complex architecture of cellular processes. Over the last decade, it has become…”
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Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…MicroRNA (miRNA) mediated silencing and repression of mRNA molecules requires complementary base pairing between the "seed" region of the miRNA and the "seed…”
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Genome-Wide Analysis of MicroRNA-Regulated Transcripts
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by either degrading transcripts or repressing translation . Over the past decade the…”
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