Search Results - "Borchers, M T"

CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung by Justice, J Paul, Crosby, J, Borchers, M T, Tomkinson, A, Lee, J J, Lee, N A

“…The potential role of airway interleukin-5 (IL-5) expression in eliciting mucus production was demonstrated in a pulmonary IL-5 transgenic mouse model…”
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Extensive Eosinophil Degranulation and Peroxidase-Mediated Oxidation of Airway Proteins Do Not Occur in a Mouse Ovalbumin-Challenge Model of Pulmonary Inflammation by Denzler, Karen L, Borchers, Michael T, Crosby, Jeffrey R, Cieslewicz, Grzegorz, Hines, Edith M, Justice, J. Paul, Cormier, Stephania A, Lindenberger, Kari A, Song, Wei, Wu, Weijia, Hazen, Stanley L, Gleich, Gerald J, Lee, James J, Lee, Nancy A

“…Paradigms of eosinophil effector function in the lungs of asthma patients invariably depend on activities mediated by cationic proteins released from secondary…”
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Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice by Justice, J Paul, Borchers, M T, Lee, J J, Rowan, W H, Shibata, Y, Van Scott, M R

“…Allergen-induced recruitment of T lymphocytes and eosinophils to the airways is associated with increased expression of the transcription factor GATA-3. In…”
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Bicalutamide (Casodex) 150 mg as immediate therapy in patients with localized or locally advanced prostate cancer significantly reduces the risk of disease progression by Wirth, M, Tyrrell, C, Wallace, M, Delaere, K.P, Sánchez-Chapado, M, Ramon, J, Hetherington, J, Pina, F, Heynes, C.F, Borchers, T.M, Morris, T, Stone, A

“…Objectives. To investigate the efficacy and tolerability of bicalutamide (Casodex) as immediate therapy, either alone or as adjuvant to treatment of curative…”
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Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment by Crosby, Jeffrey R, Shen, H H, Borchers, M T, Justice, J P, Ansay, T, Lee, J J, Lee, N A

“…CD4(+) T cells have a critical role in the development of allergic pulmonary inflammation, including the recruitment of eosinophils to the airway lumen and…”
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A Causative Relationship Exists Between Eosinophils and the Development of Allergic Pulmonary Pathologies in the Mouse by Shen, HuaHao H, Ochkur, Sergei I, McGarry, Michael P, Crosby, Jeffrey R, Hines, Edie M, Borchers, Michael T, Wang, Huiying, Biechelle, Travis L, O'Neill, Katie R, Ansay, Tracy L, Colbert, Dana C, Cormier, Stephania A, Justice, J. Paul, Lee, Nancy. A, Lee, James J

“…Asthma and mouse models of allergic respiratory inflammation are invariably associated with a pulmonary eosinophilia; however, this association has remained…”
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Regulation of human airway mucins by acrolein and inflammatory mediators by Borchers, M T, Carty, M P, Leikauf, G D

“…Bronchitis, asthma, and cystic fibrosis, marked by inflammation and mucus hypersecretion, can be caused or exacerbated by airway pathogens or irritants…”
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In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration by Borchers, Michael T., Ansay, Tracy, DeSalle, Rob, Daugherty, Bruce L., Shen, Huahao, Metzger, Michael, Lee, Nancy A., Lee, James J.

“…Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G‐protein‐coupled chemokine receptors (CCR). Studies of human…”
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Acrolein-induced MUC5ac expression in rat airways by Borchers, M T, Wert, S E, Leikauf, G D

“…Acrolein, a low-molecular-weight aldehyde found in photochemical smog and tobacco smoke, can induce mucus hypersecretion, inflammation, and airway…”
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Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment by Borchers, M T, Crosby, J, Farmer, S, Sypek, J, Ansay, T, Lee, N A, Lee, J J

“…Lymphocyte and/or eosinophil recruitment is dependent on the sequential interactions between adhesion molecules expressed on activated endothelial cells and…”
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Monocyte inflammation augments acrolein-induced Muc5ac expression in mouse lung by Borchers, M T, Wesselkamper, S, Wert, S E, Shapiro, S D, Leikauf, G D

“…Acrolein, an unsaturated aldehyde found in smog and tobacco smoke, can induce airway hyperreactivity, inflammation, and mucus hypersecretion. To determine…”
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D104 ADVANCES IN INTERSTITIAL LUNG DISEASE: Nkg2d Ligand Expression In Lymphangioleiomyomatosis by Foot, R A, Osterburg, A, Nelson, R, McCormack, F X, Borchers, M T

“…Methods: We examined cell surface NKG2D ligand expression on human transformed and primary LAM cells and mouse Tsc-deficient embryonic fibroblasts by flow…”
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D104 ADVANCES IN INTERSTITIAL LUNG DISEASE: Molecular And Cellular Mechanisms Of Pulmonary Langerhans Cell Histiocytosis by Liu, H, McCormack, F X, Borchers, M T, Osterburg, A, Flury, J

“…Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare interstitial lung disease identified by focal Langerin+ dendritic cell (DC) accumulation, development…”
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Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling by Borchers, M T, Crosby, J, Justice, P, Farmer, S, Hines, E, Lee, J J, Lee, N A

“…Overexpression of interleukin (IL)-5 by the airway epithelium in mice using the rat CC10 promoter (NJ.1726 line) leads to several histopathologies…”
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Pseudomonas aeruginosa Exotoxin Pyocyanin Causes Cystic Fibrosis Airway Pathogenesis by Caldwell, Charles C, Chen, Yi, Goetzmann, Holly S, Hao, Yonghua, Borchers, Michael T, Hassett, Daniel J, Young, Lisa R, Mavrodi, Dmitri, Thomashow, Linda, Lau, Gee W

“…The cystic fibrosis (CF) airway bacterial pathogen Pseudomonas aeruginosa secretes multiple virulence factors. Among these, the redox active exotoxin pyocyanin…”
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Priapism - a surgical emergency by Borchers, T.M. & Barnes, D.R.

“…Priapism is a surgical emergency, and a glandular cavernous shunt is good emergency treatment…”
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Loss of D1 and D2 dopamine receptors and muscarinic cholinergic receptors in rat brain following in vitro polytron homogenization by Norman, A B, Borchers, M T, Wachendorf, T J, Price, A L, Sanberg, P R

“…The receptor specific binding of [3H]SCH23390 and [3H]spiperone to rat striatal membranes and [3H]QNB to rat cortical membranes was significantly reduced if…”
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A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species by Brennan, Marie-Luise, Wu, Weijia, Fu, Xiaoming, Shen, Zhongzhu, Song, Wei, Frost, Heather, Vadseth, Caryn, Narine, Laura, Lenkiewicz, Elizabeth, Borchers, Michael T, Lusis, Aldons J, Lee, James J, Lee, Nancy A, Abu-Soud, Husam M, Ischiropoulos, Harry, Hazen, Stanley L

“…Nitrotyrosine is widely used as a marker of post-translational modification by the nitric oxide ((.)NO, nitrogen monoxide)-derived oxidant peroxynitrite…”
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Metalloproteinases Mediate Mucin 5AC Expression by Epidermal Growth Factor Receptor Activation by Deshmukh, Hitesh S, Case, Lisa M, Wesselkamper, Scott C, Borchers, Michael T, Martin, Linda D, Shertzer, Howard G, Nadel, Jay A, Leikauf, George D

“…Chronic obstructive pulmonary disease is marked by alveolar enlargement and excess production of airway mucus. Acrolein, a component of cigarette smoke,…”
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Gene expression changes during the development of acute lung injury : Role of transforming growth factor β by WESSELKAMPER, Scott C, CASE, Lisa M, LEIKAUF, George D, HENNING, Lisa N, BORCHERS, Michael T, TICHELAAR, Jay W, MASON, John M, DRAGIN, Nadine, MEDVEDOVIC, Mario, SARTOR, Maureen A, TOMLINSON, Craig R

“…Acute lung injury can occur from multiple causes, resulting in high mortality. The pathophysiology of nickel-induced acute lung injury in mice is remarkably…”
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