Search Results - "Borbat, Peter P."

Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB by Cooper, Rebecca S., Georgieva, Elka R., Borbat, Peter P., Freed, Jack H., Heldwein, Ekaterina E.

“…Viral fusogens merge viral and cell membranes during cell penetration. Their ectodomains drive fusion by undergoing large-scale refolding, but little is known…”
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Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding Repeats by Georgieva, Elka R., Xiao, Shifeng, Borbat, Peter P., Freed, Jack H., Eliezer, David

“…Tau is a microtubule-associated protein that is genetically linked to dementia and linked to Alzheimer’s disease via its presence in intraneuronal…”
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Conformational ensemble of the sodium-coupled aspartate transporter by Georgieva, Elka R, Borbat, Peter P, Ginter, Christopher, Freed, Jack H, Boudker, Olga

“…The sodium and aspartate symporter Glt Ph mediates transport by alternating between outward-facing and inward-facing states. These conformational changes are…”
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Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation by Choi, Yong Mi, Ajjaji, Dalila, Fleming, Kaelin D., Borbat, Peter P., Jenkins, Meredith L., Moeller, Brandon E., Fernando, Shaveen, Bhatia, Surita R., Freed, Jack H., Burke, John E., Thiam, Abdou Rachid, Airola, Michael V.

“…Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and…”
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Signal transduction in light–oxygen–voltage receptors lacking the adduct-forming cysteine residue by Yee, Estella F., Diensthuber, Ralph P., Vaidya, Anand T., Borbat, Peter P., Engelhard, Christopher, Freed, Jack H., Bittl, Robert, Möglich, Andreas, Crane, Brian R.

“…Light–oxygen–voltage (LOV) receptors sense blue light through the photochemical generation of a covalent adduct between a flavin-nucleotide chromophore and a…”
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Signature of an aggregation-prone conformation of tau by Eschmann, Neil A., Georgieva, Elka R., Ganguly, Pritam, Borbat, Peter P., Rappaport, Maxime D., Akdogan, Yasar, Freed, Jack H., Shea, Joan-Emma, Han, Songi

“…The self-assembly of the microtubule associated tau protein into fibrillar cell inclusions is linked to a number of devastating neurodegenerative disorders…”
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HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association by Majeed, Saman, Dang, Lan, Islam, Md Majharul, Ishola, Olamide, Borbat, Peter P., Ludtke, Steven J., Georgieva, Elka R.

“…We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a…”
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Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance by Lai, Alex L., Clerico, Eugenia M., Blackburn, Mandy E., Patel, Nisha A., Robinson, Carol V., Borbat, Peter P., Freed, Jack H., Gierasch, Lila M.

“…Proteins are dynamic entities that populate conformational ensembles, and most functions of proteins depend on their dynamic character. Allostery, in…”
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Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes by Georgieva, Elka R., Borbat, Peter P., Norman, Haley D., Freed, Jack H.

“…M2 from influenza A virus functions as an oligomeric proton channel essential for the viral cycle, hence it is a high-priority pharmacological target whose…”
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The crystal structure of bacteriophage λ RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins by Adams, Myfanwy C, Schiltz, Carl J, Sun, Jing, Hosford, Christopher J, Johnson, Virginia M, Pan, Hao, Borbat, Peter P, Freed, Jack H, Thomason, Lynn C, Court, Carolyn, Court, Donald L, Chappie, Joshua S

“…RexA and RexB function as an exclusion system that prevents bacteriophage T4rII mutants from growing on Escherichia coli λ phage lysogens. Recent data…”
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Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments by Tang, Shaogeng, Henne, W Mike, Borbat, Peter P, Buchkovich, Nicholas J, Freed, Jack H, Mao, Yuxin, Fromme, J Christopher, Emr, Scott D

“…The endosomal sorting complexes required for transport (ESCRTs) constitute hetero-oligomeric machines that catalyze multiple topologically similar…”
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Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances by Samanta, Dipanjan, Borbat, Peter P., Dzikovski, Boris, Freed, Jack H., Crane, Brian R.

“…Significance Bacterial chemoreceptors are a key system for understanding how conformational signals propagate over large distances in transmembrane signaling…”
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Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor by Samanta, Dipanjan, Widom, Joanne, Borbat, Peter P., Freed, Jack H., Crane, Brian R.

“…Flagellated bacteria modulate their swimming behavior in response to environmental cues through the CheA/CheY signaling pathway. In addition to responding to…”
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Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States by Merz, Gregory E., Borbat, Peter P., Pratt, Ashley J., Getzoff, Elizabeth D., Freed, Jack H., Crane, Brian R.

“…We demonstrate the ability of pulsed dipolar electron spin resonance (ESR) spectroscopy (PDS) to report on the conformation of Cu-Zn superoxide dismutase…”
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The determination of pair distance distributions by pulsed ESR using Tikhonov regularization by Chiang, Yun-Wei, Borbat, Peter P., Freed, Jack H.

“…Pulsed ESR techniques with the aid of site-directed spin labeling have proven useful in providing unique structural information about proteins. The…”
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scissors mechanism for stimulation of SNARE-mediated lipid mixing by cholesterol by Tong, Jiansong, Borbat, Peter P, Freed, Jack H, Shin, Yeon-Kyun

“…Neurotransmitter release at the synapse requires membrane fusion. The SNARE complex, composed of the plasma membrane t-SNAREs syntaxin 1A and SNAP-25 and the…”
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Assembly States of FliM and FliG within the Flagellar Switch Complex by Sircar, Ria, Borbat, Peter P., Lynch, Michael J., Bhatnagar, Jaya, Beyersdorf, Matthew S., Halkides, Christopher J., Freed, Jack H., Crane, Brian R.

“…At the base of the bacterial flagella, a cytoplasmic rotor (the C-ring) generates torque and reverses rotation sense in response to stimuli. The bulk of the…”
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Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt, Ashley J., Shin, David S., Merz, Gregory E., Rambo, Robert P., Lancaster, W. Andrew, Dyer, Kevin N., Borbat, Peter P., Poole, Farris L., Adams, Michael W. W., Freed, Jack H., Crane, Brian R., Tainer, John A., Getzoff, Elizabeth D.

“…Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron…”
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HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors by Airola, Michael V, Sukomon, Nattakan, Samanta, Dipanjan, Borbat, Peter P, Freed, Jack H, Watts, Kylie J, Crane, Brian R

“…HAMP domains are signal relay modules in >26,000 receptors of bacteria, eukaryotes, and archaea that mediate processes involved in chemotaxis, pathogenesis,…”
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Reconstruction of the chemotaxis receptor-kinase assembly by Crane, Brian R, Park, Sang-Youn, Borbat, Peter P, Gonzalez-Bonet, Gabriela, Bhatnagar, Jaya, Pollard, Abiola M, Freed, Jack H, Bilwes, Alexandrine M

“…In bacterial chemotaxis, an assembly of transmembrane receptors, the CheA histidine kinase and the adaptor protein CheW processes environmental stimuli to…”
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