Receptor-binding properties of influenza viruses isolated from gulls

Receptor-binding properties of influenza viruses isolated from gulls

Ducks, gulls and shorebirds represent the major hosts of influenza A viruses (IAVs) in nature, but distinctions of IAVs in different birds are not well defined. Here we characterized the receptor specificity of gull IAVs with HA subtypes H4, H6, H14, H13 and H16 using synthetic sialylglycopolymers....

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Bibliographic Details
Published in:Virology (New York, N.Y.) Vol. 522; pp. 37 - 45
Main Authors: Gambaryan, Alexandra S., Matrosovich, Tatyana Y., Boravleva, Elisaveta Y., Lomakina, Natalia F., Yamnikova, Svetlana S., Tuzikov, Alexander B., Pazynina, Galina V., Bovin, Nicolai V., Fouchier, Ron A.M., Klenk, Hans-Dieter, Matrosovich, Mikhail N.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-09-2018
Subjects:
Adaptation
Aquatic birds
Fucose
Hemagglutinin
Influenza
Receptor specificity
Receptor-binding site
Sialic
Transmission
Receptor specificity
Receptor-binding site
Hemagglutinin
Influenza
Transmission
Sialic
Aquatic birds
Fucose
Adaptation
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Summary:Ducks, gulls and shorebirds represent the major hosts of influenza A viruses (IAVs) in nature, but distinctions of IAVs in different birds are not well defined. Here we characterized the receptor specificity of gull IAVs with HA subtypes H4, H6, H14, H13 and H16 using synthetic sialylglycopolymers. In contrast to duck IAVs, gull IAVs efficiently bound to fucosylated receptors and often preferred sulfated and non-sulfated receptors with Galβ1–4GlcNAc cores over the counterparts with Galβ1–3GlcNAc cores. Unlike all other IAVs of aquatic birds, H16 IAVs showed efficient binding to Neu5Acα2–6Gal-containing receptors and bound poorly to Neu5Acα2–3Galβ1–3-terminated (duck-type) receptors. Analysis of HA crystal structures and amino acid sequences suggested that the amino acid at position 222 is an important determinant of the receptor specificity of IAVs and that transmission of duck viruses to gulls and shorebirds is commonly accompanied by substitutions at this position.
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ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2018.07.004