Search Results - "Boraschi, D."

Challenges in the design of clinically useful brain-targeted drug nanocarriers by Costantino, L, Boraschi, D, Eaton, M

“…Nowadays, the delivery of drugs by means of intravenously administered nanosized drug carriers - polymerdrug conjugates, liposomes and micelles, is technically…”
Get more information

Free IL-18 and IL-33 cytokines in chronic spontaneous urticaria by Puxeddu, I., Italiani, P., Giungato, P., Pratesi, F., Panza, F., Bartaloni, D., Rocchi, V., Del Corso, I., Boraschi, D., Migliorini, P.

“…► In chronic spontaneous urticaria free IL-18 is increased. ► IL-18 binding protein counteracts the inflammatory effects of IL-18. ► IL-33 does not play a role…”
Get full text

Cytokines and soluble receptors of the interleukin-1 family in Schnitzler syndrome by Migliorini, P, Italiani, P, Pratesi, F, Puxeddu, I, Boraschi, D

“…Objectives: Schnitzler syndrome (SchS) is an autoinflammatory disorder characterized by chronic urticaria, fever, and monoclonal gammopathy. The success of…”
Get full text

Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project by Winterer, G., Androsova, G., Bender, O., Boraschi, D., Borchers, F., Dschietzig, T.B., Feinkohl, I., Fletcher, P., Gallinat, J., Hadzidiakos, D., Haynes, J.D., Heppner, F., Hetzer, S., Hendrikse, J., Ittermann, B., Kant, I.M.J., Kraft, A., Krannich, A., Krause, R., Kühn, S., Lachmann, G., van Montfort, S.J.T., Müller, A., Nürnberg, P., Ofosu, K., Pietsch, M., Pischon, T., Preller, J., Renzulli, E., Scheurer, K., Schneider, R., Slooter, A.J.C., Spies, C., Stamatakis, E., Volk, H.D., Weber, S., Wolf, A., Yürek, F., Zacharias, N.

“…Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In…”
Get full text

Does immunotoxicity of nanomaterials depend on the individual pre-existing conditions? A need for a personalised testing strategy by Boraschi, D., Italiani, P.

Get full text

The Membrane Form of the Type II IL-1 Receptor Accounts for Inhibitory Function by Neumann, Detlef, Kollewe, Christian, Martin, Michael U, Boraschi, Diana

“…IL-1 signaling is mediated by the type I IL-1R (IL-1RI). The nonsignaling type II receptor has a regulatory function, since it reduces IL-1 effects by…”
Get full text

Human Peritoneal Mesothelial Cells Produce Many Cytokines (Granulocyte Colony-Stimulating Factor [CSF], Granulocyte-Monocyte–CSF, Macrophage-CSF, Interleukin-1 [IL-1], and IL-6) and Are Activated and Stimulated to Grow by IL-1 by Lanfrancone, L., Boraschi, D., Ghiara, P., Falini, B., Grignani, F., Peri, G., Mantovani, A., Pelicci, P.G.

“…To investigate the role of peritoneal mesothelial cells in regulating hematopoiesis, as well as inflammation, healing, and tissue regeneration processes,…”
Get full text

Nanoparticles and innate immunity: new perspectives on host defence by Boraschi, Diana, Italiani, Paola, Palomba, Roberto, Decuzzi, Paolo, Duschl, Albert, Fadeel, Bengt, Moghimi, S. Moein

“…[Display omitted] •The innate immune system is the first to come in contact with NPs entering the body.•Contamination of NPs with LPS may skew the…”
Get full text

Lymphocytes from Autoimmune MRL lpr/lpr Mice Are Hyperresponsive to IL-18 and Overexpress the IL-18 Receptor Accessory Chain by Neumann, Detlef, Del Giudice, Elda, Ciaramella, Antonio, Boraschi, Diana, Bossu, Paola

“…MRL lpr/lpr mice spontaneously develop a severe autoimmune lupus syndrome characterized by strong autoantibody production and massive lymphoproliferation, in…”
Get full text

Interleukin-1 and Interleukin-1 Fragments as Vaccine Adjuvants by Boraschi, Diana, Tagliabue, Aldo

“…The human interleukin-1β (IL-1β) domain in position 163–171, comprising the amino acids VQGEESNDK, has been synthesized as a nine-amino-acid-long peptide and…”
Get full text

Bovine colon organoids: From 3D bioprinting to cryopreserved multi-well screening platforms by Töpfer, Elfi, Pasotti, Anna, Telopoulou, Aikaterini, Italiani, Paola, Boraschi, Diana, Ewart, Marie-Ann, Wilde, Colin

“…Three-dimensional (3D) colon organoids, termed “colonoids”, derived from adult stem cells represent a powerful tool in in vitro pharmaceutical and…”
Get full text

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice by GIAVAZZI, R, GAROFALO, A, BANI, G. M, ABBATE, M, GHEZZI, P, BORASCHI, D, MONTOVANI, A, DEJANA, E

“…This study has examined the effect of the cytokine interleukin 1 (IL-1) on metastasis formation by the human melanoma A375M in nude mice. We have found that…”
Get full text

Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production by Boraschi, D, Censini, S, Tagliabue, A

“…Normal peritoneal M phi of C3H/HeN mice were able to suppress lymphocyte proliferation in a dose-dependent fashion when added to Con A-pulsed spleen cell…”
Get full text

IL-18 and IL-18 receptors in the development of autoimmunity by Bossù, P, Del Giudice, E, Ciaramella, A, Neumann, D, Boraschi, D

Get more information

A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity by Antoni, G, Presentini, R, Perin, F, Tagliabue, A, Ghiara, P, Censini, S, Volpini, G, Villa, L, Boraschi, D

“…Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an…”
Get full text

Differential binding of IL‐ 1α and IL‐ 1β to receptors on B and T cells by Scapigliati, G., Ghiara, P., Bartalini, M., Tagliabue, A., Boraschi, D.

“…The interleukin 1 receptors (IL‐1R) on the human B lymphoma RAJI and on the murine thymoma EL4‐6.1 have been characterized. Equilibrium binding analysis using…”
Get full text

Single-Cell Analysis of Macrophage Chemotactic Protein-1-Regulated Cytosolic Ca2+ Increase in Human Adherent Monocytes by Bizzarri, Cinzia, Bertini, Riccardo, Bossu, Paola, Sozzani, Silvano, Mantovani, Alberto, Darnme, Jo Van, Tagliabue, Aldo, Boraschi, Diana

“…The increase in intracellular free Ca2+ ([Ca2+]i) associated with interaction of monocyte chemotactic protein-1 (MCP-1) and related chemokines p with adherent…”
Get full text

Regulation of arachidonic acid metabolism in macrophages by immune and nonimmune interferons by Boraschi, D, Censini, S, Bartalini, M, Tagliabue, A

“…Mouse resident peritoneal M phi release AAA and metabolize it into cyclooxygenase- and lipoxygenase-derived eicosanoids, when triggered in vitro with different…”
Get full text

Robust Immune Response Induced by Schistosoma mansoni TSP-2 Antigen Coupled to Bacterial Outer Membrane Vesicles by Barbosa, Mayra M F, Kanno, Alex I, Barazzone, Giovana C, Rodriguez, Dunia, Pancakova, Violeta, Trentini, Monalisa, Faquim-Mauro, Eliana L, Freitas, Amanda P, Khouri, Mariana I, Lobo-Silva, Jessica, Goncalves, Viviane M, Schenkman, Rocilda P F, Tanizaki, Martha M, Boraschi, Diana, Malley, Richard, Farias, Leonardo P, Leite, Luciana C C

“…The use of adjuvants can significantly strengthen a vaccine's efficacy. We sought to explore the immunization efficacy of bacterial outer membrane vesicles…”
Get full text

Neutrophil apoptosis in autoimmune Fas-defective MRL lpr/lpr mice by Giudice, E D, Ciaramella, A, Balestro, N, Neumann, D, Romano, P G, Cesaroni, M P, Maurizi, G, Ruggiero, P, Boraschi, D, Bossù, P

“…The apoptosis-defective lpr (fas) mutation in MRL mice causes the early onset of a lupus-like autoimmune disease with concomitant inflammation. In order to…”
Get more information