Search Results - "Boralli, V B"

Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach by van Steeg, T J, Boralli, V B, Krekels, E H J, Slijkerman, P, Freijer, J, Danhof, M, de Lange, E C M

“…The objective of this investigation was to examine in a systematic manner the influence of plasma protein binding on in vivo pharmacodynamics. Comparative…”
Get more information

ABCG2 polymorphism and rivaroxaban pharmacokinetics in healthy individuals after a single dose by Santos, A F Dos, Francisco, Q A S, Nunes, J B, Colombo, F A, Boralli, V B

“…Rivaroxaban is a direct factor Xa inhibitor. Its interindividual variability is large and may be connected to the occurrence of adverse drug reactions or drug…”
Get full text

Reduction of enantioselectivity in the kinetic disposition and metabolism of verapamil in rats exposed to toluene by Mateus, F H, Lepera, J S, Marques, M P, Boralli, V B, Lanchote, V L

“…Toluene and verapamil are subject to extensive oxidative metabolism mediated by CYP enzymes, and their interaction can be stereoselective. In the present study…”
Get more information

Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism by Boralli, Vanessa Bergamin, Coelho, Eduardo Barbosa, Cerqueira, Paula Macedo, Lanchote, Vera Lucia

“…We investigated the stereoselective kinetic disposition and metabolism of metoprolol (MET) in rats. The racemic MET (15 mg/kg) was given by oral gavage and…”
Get full text

Enantioselective determination of metoprolol acidic metabolite in plasma and urine using liquid chromatography chiral columns: applications to pharmacokinetics by Cerqueira, Paula Macedo, Boralli, Vanessa Bergamin, Coelho, Eduardo Barbosa, Lopes, Norberto Peporine, Guimarães, Luis Fernando Lopes, Bonato, Pierina Sueli, Lanchote, Vera Lucia

“…Enantioselective separations on chiral stationary phases with or without derivatization were developed and compared for the HPLC analysis of (+)-( R)- and…”
Get full text