Disseminated Intravascular Coagulation

Disseminated Intravascular Coagulation

Objectives: To provide a review of the definition, pathophysiology, differential diagnosis, and treatment of disseminated intravascular coagulation (DIC). Methods: A case scenario and a review of the literature related to the pertinent facts concerning DIC are provided. Results: DIC is a systemic pa...

Full description

Saved in:
Bibliographic Details
Published in:American journal of clinical pathology Vol. 146; no. 6; pp. 670 - 680
Main Authors: Boral, Benjamin M., Williams, Dennis J., Boral, Leonard I.
Format: Journal Article
Language:English
Published: England Oxford University Press 01-12-2016
Subjects:
Adult
Blood Coagulation - physiology
Blood platelets
Diagnosis, Differential
Disseminated intravascular coagulation
Disseminated Intravascular Coagulation - blood
Disseminated Intravascular Coagulation - diagnosis
Emergency medical care
Endothelium
Family medical history
Hematology
Hemorrhage
Humans
Intensive care
Laboratories
Liver cirrhosis
Male
Patients
Physiology
Sepsis
Thrombosis
Vital signs
Thrombocytopenia
Thrombin
Thrombi
Hemorrhage
Coagulopathy
DIC
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: To provide a review of the definition, pathophysiology, differential diagnosis, and treatment of disseminated intravascular coagulation (DIC). Methods: A case scenario and a review of the literature related to the pertinent facts concerning DIC are provided. Results: DIC is a systemic pathophysiologic process and not a single disease entity, resulting from an overwhelming activation of coagulation that consumes platelets and coagulation factors and causes microvascular fibrin thrombi, which can result in multiorgan dysfunction syndrome from tissue ischemia. Some conditions associated with acute DIC include septic shock, exsanguinating trauma, burns, or acute promyelocytic leukemia. Conclusions: The massive tissue factor stimulus results in excess intravascular thrombin, which overcomes the anticoagulant systems and leads to thrombosis. Because of consumption of coagulation factors and platelets, DIC also has a hemorrhagic phase. Treatment of the bleeding patient with DIC is supportive with the use of blood components.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqw195