Search Results - "Borén, J."

Ectopic lipid storage and insulin resistance: a harmful relationship by Borén, J., Taskinen, M.‐R., Olofsson, S.‐O., Levin, M.

“…Obesity increases the risk of metabolic diseases, including insulin resistance and type 2 diabetes, as well as cardiovascular disease. In addition to lipid…”
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The small leucine‐rich repeat proteoglycans in tissue repair and atherosclerosis by Hultgårdh‐Nilsson, A., Borén, J., Chakravarti, S.

“…Proteoglycans consist of a protein core with one or more covalently attached glycosaminoglycan (GAG) side chains and have multiple roles in the initiation and…”
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Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis by Fogelstrand, P, Borén, J

“…Abstract Aims In this review, we discuss the mechanisms behind the binding of low-density lipoproteins (LDL) to the arterial wall and how this interaction…”
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Investigation of human apoB48 metabolism using a new, integrated non‐steady‐state model of apoB48 and apoB100 kinetics by Björnson, E., Packard, C. J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Sihlbom, C., Thorsell, A., Zhou, H., Taskinen, M.‐R., Borén, J.

“…Background Triglyceride‐rich lipoproteins and their remnants have emerged as major risk factors for cardiovascular disease. New experimental approaches are…”
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Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes by Ståhlman, M., Pham, H. T., Adiels, M., Mitchell, T. W., Blanksby, S. J., Fagerberg, B., Ekroos, K., Borén, J.

“…Aims/hypothesis The aim of this study was to use lipidomics to determine if the lipid composition of apolipoprotein-B-containing lipoproteins is modified by…”
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Apolipoprotein B48 metabolism in chylomicrons and very low‐density lipoproteins and its role in triglyceride transport in normo‐ and hypertriglyceridemic human subjects by Björnson, E., Packard, C.J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Lundbom, J., Sihlbom, C., Thorsell, A., Zhou, H., Taskinen, M.‐R., Borén, J.

“…Background Renewed interest in triglyceride‐rich lipoproteins as causative agents in cardiovascular disease mandates further exploration of the integrated…”
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Acute suppression of VLDL₁ secretion rate by insulin is associated with hepatic fat content and insulin resistance by Adiels, M, Westerbacka, J, Soro-Paavonen, A, Häkkinen, A. M, Vehkavaara, S, Caslake, M. J, Packard, C, Olofsson, S. O, Yki-Järvinen, H, Taskinen, M. R, Borén, J

“…Aims/hypothesis Overproduction of VLDL₁ seems to be the central pathophysiological feature of the dyslipidaemia associated with type 2 diabetes. We explored…”
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Interaction of chylomicron remnants and VLDLs during ultracentrifuge separation based on the Svedberg flotation rate – Authors’ response by Björnson, E., Packard, C.J., Taskinen, M.‐R., Borén, J.

“…Click here to view the Letter to the Editor by Stellaard and Lütjohann…”
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A 7‐day high‐fat, high‐calorie diet induces fibre‐specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle by Whytock, K. L., Parry, S. A., Turner, M. C., Woods, R. M., James, L. J., Ferguson, R. A., Ståhlman, M., Borén, J., Strauss, J. A., Cocks, M., Wagenmakers, A. J. M., Hulston, C. J., Shepherd, S. O.

“…Key points We have recently shown that a high‐fat, high‐calorie (HFHC) diet decreases whole body glucose clearance without impairing skeletal muscle insulin…”
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Genetic diagnosis of familial hypercholesterolaemia by targeted next‐generation sequencing by Maglio, C., Mancina, R. M., Motta, B. M., Stef, M., Pirazzi, C., Palacios, L., Askaryar, N., Borén, J., Wiklund, O., Romeo, S.

“…Objectives The aim of this study was to combine clinical criteria and next‐generation sequencing (pyrosequencing) to establish a diagnosis of familial…”
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(379) - Monogenic and Polygenic Contributions to Early Onset Advanced Heart Failure Based on Whole Genome Sequencing by Linner, E., Czuba, T., Gidlöf, O., Lundgren, J., Bollano, E., Hellberg, M., Celik, S., Pimpalwar, N., Rentzsch, P., Martorella, M., Gummessson, A., Melander, O., Albinsson, S., Dellgren, G., Borén, J., Jeppsson, A., Lumbers, T., Shah, S., Nilsson, J., Natarajan, P., Lappalainen, T., Levin, M., Ehrencrona, H., Smith, J.

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Kinetic studies to investigate lipoprotein metabolism by Borén, J., Taskinen, M.-R., Adiels, M.

“…Borén J, Taskinen M‐R, Adiels M (University of Gothenburg, Gothenburg, Sweden; University of Helsinki, Helsinki, Finland; and University of Gothenburg,…”
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Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network analysis by Adiels, M., Chapman, M.J., Robillard, P., Krempf, M., Laville, M., Borén, J.

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Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele by Padayachee, E, Zetterberg, H, Portelius, E, Borén, J, Molinuevo, J.L, Andreasen, N, Cukalevski, R, Linse, S, Blennow, K, Andreasson, U

“…Abstract Misfolding and aggregation of amyloid β (Aβ) are key features of Alzheimer's disease (AD) pathogenesis, but the molecular events controlling this…”
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Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy by Saliba‐Gustafsson, P., Pedrelli, M., Gertow, K., Werngren, O., Janas, V., Pourteymour, S., Baldassarre, D., Tremoli, E., Veglia, F., Rauramaa, R., Smit, A.J., Giral, P., Kurl, S., Pirro, M., Faire, U., Humphries, S.E., Hamsten, A., Gonçalves, I., Orho‐Melander, M., Franco‐Cereceda, A., Borén, J., Eriksson, P., Magné, J., Parini, P., Ehrenborg, E., Sirtori, C. R., Castelnuovo, S., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Bovis, F., Discacciati, A., Ahl, M., Blomgren, G., Eriksson, M. J., Fahlstadius, P., Heinonen, M., Nilson, L., Cooper, J., Acharya, J., Huttunen, K., Rauramaa, E., Pekkarinen, H., Penttila, I. M., Torronen, J., Gessel, A. I., van Roon, A. M., Teune, G. C., Kuipers, W. D., Bruin, M., Nicolai, A., Haarsma‐Jorritsma, P., Mulder, D. J., Bilo, H. J. G., Smeets, G. H., Beaudeux, J. L., Kahn, J. F., Carreau, V., Kontush, A., Karppi, J., Nurmi, T., Nyyssonen, K., Salonen, R., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Vaudo, G., Alaeddin, A., Siepi, D., Lupattelli, G., Schillaci, G.

“…Background Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and…”
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Intimal hyperplasia promotes vascular lipoprotein retention and accelerates formation of atherosclerotic lesions by Kijani, S, Levin, M, Borén, J, Fogelstrand, P

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Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men by Matikainen, N, Söderlund, S, Björnson, E, Bogl, L.H, Pietiläinen, K.H, Hakkarainen, A, Lundbom, N, Eliasson, B, Räsänen, S.M, Rivellese, A, Patti, L, Prinster, A, Riccardi, G, Després, J.-P, Alméras, N, Holst, J.J, Deacon, C.F, Borén, J, Taskinen, M.-R

“…Abstract Background and aims Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in…”
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Microsomal triglyceride transfer protein in the ischemic heart by Klevstig, M, Scharin Täng, M, Ståhlman, M, Levin, M, Borén, J

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Evaluation of macrophage-specific promoters using lentiviral delivery in mice by Levin, M C, Lidberg, U, Jirholt, P, Adiels, M, Wramstedt, A, Gustafsson, K, Greaves, D R, Li, S, Fazio, S, Linton, M F, Olofsson, S-O, Borén, J, Gjertsson, I

“…In gene therapy, tissue-specific promoters are useful tools to direct transgene expression and improve efficiency and safety. Macrophage-specific promoters…”
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Ceramides are associated with inflammatory processes in human mediastinal adipose tissue by Gertow, J, Kjellqvist, S, Ståhlman, M, Cheung, L, Gottfries, J, Werngren, O, Borén, J, Franco-Cereceda, A, Eriksson, P, Fisher, R.M

“…Abstract Background and Aim Ceramides are poorly characterized in human adipose tissue. The aim of this study was to investigate concentrations of different…”
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