Search Results - "Boquín, José R"

New TLR7 agonists with improved humoral and cellular immune responses by Upchurch, Katherine C, Boquín, José R, Yin, Wenjie, Xue, Yaming, Joo, HyeMee, Kane, Robert R, Oh, SangKon

“…Highlights • We have developed two new TLR7 agonists, J4 and F4. • They induce phenotype maturation of antigen presenting cells (APCs). • However, they induce…”
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Facile syntheses of functionalized toll-like receptor 7 agonists by Akinbobuyi, Babatope, Byrd, Matthew R., Chang, Charles A., Nguyen, Mysa, Seifert, Zacharie J., Flamar, Anne-Laure, Zurawski, Gerard, Upchurch, Katherine C., Oh, SangKon, Dempsey, Stephen H., Enke, Thomas J., Le, John, Winstead, Hunter J., Boquín, José R., Kane, Robert R.

“…9 new TLR-7 agonists; 10–70% overall for 4–7 steps. X=H, I, CO2H, CN, CONH2, CCCH2OH, CCCH2NH2, (CH2)3NH2, CONHCH2CH2NH2, CONH-PEG2-NH2. [Display omitted]…”
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Synthesis and immunostimulatory activity of substituted TLR7 agonists by Akinbobuyi, Babatope, Wang, Lei, Upchurch, Katherine C., Byrd, Matthew R., Chang, Charles A., Quintana, Jeremy M., Petersen, Rachel E., Seifert, Zacharie J., Boquin, José R., Oh, SangKon, Kane, Robert R.

“…[Display omitted] Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds,…”
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