Search Results - "Bopp, Selina E"

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families by Bopp, Selina E R, Manary, Micah J, Bright, A Taylor, Johnston, Geoffrey L, Dharia, Neekesh V, Luna, Fabio L, McCormack, Susan, Plouffe, David, McNamara, Case W, Walker, John R, Fidock, David A, Denchi, Eros Lazzerini, Winzeler, Elizabeth A

“…Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses…”
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CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs by Ng, Caroline L., Siciliano, Giulia, Lee, Marcus C. S., de Almeida, Mariana J., Corey, Victoria C., Bopp, Selina E., Bertuccini, Lucia, Wittlin, Sergio, Kasdin, Rachel G., Le Bihan, Amélie, Clozel, Martine, Winzeler, Elizabeth A., Alano, Pietro, Fidock, David A.

“…Summary Emerging resistance to first‐line antimalarial combination therapies threatens malaria treatment and the global elimination campaign. Improved…”
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Validation of isoleucine utilization targets in Plasmodium falciparum by Istvan, Eva S., Dharia, Neekesh V., Bopp, Selina E., Gluzman, Ilya, Winzeler, Elizabeth A., Goldberg, Daniel E., Wellems, Thomas E.

“…Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine,…”
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Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites by Dharia, Neekesh V, Plouffe, David, Bopp, Selina E R, González-Páez, Gonzalo E, Lucas, Carmen, Salas, Carola, Soberon, Valeria, Bursulaya, Badry, Kochel, Tadeusz J, Bacon, David J, Winzeler, Elizabeth A

“…Here, we fully characterize the genomes of 14 Plasmodium falciparum patient isolates taken recently from the Iquitos region using genome scanning, a…”
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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery by Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.

“…Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against…”
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Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival by Bopp, Selina E R, Ramachandran, Vandana, Henson, Kerstin, Luzader, Angelina, Lindstrom, Merle, Spooner, Muriel, Steffy, Brian M, Suzuki, Oscar, Janse, Chris, Waters, Andrew P, Zhou, Yingyao, Wiltshire, Tim, Winzeler, Elizabeth A

“…The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have…”
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Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 by Bopp, Selina E R, Rodrigo, Evelyn, González-Páez, Gonzalo E, Frazer, Mary, Barnes, S Whitney, Valim, Clarissa, Watson, James, Walker, John R, Schmedt, Christian, Winzeler, Elizabeth A

“…One of the main causes of mortality from severe malaria in Plasmodium falciparum infections is cerebral malaria (CM). An important host genetic component…”
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs by Herman, Jonathan D, Pepper, Lauren R, Cortese, Joseph F, Estiu, Guillermina, Galinsky, Kevin, Zuzarte-Luis, Vanessa, Derbyshire, Emily R, Ribacke, Ulf, Lukens, Amanda K, Santos, Sofia A, Patel, Vishal, Clish, Clary B, Sullivan, Jr, William J, Zhou, Huihao, Bopp, Selina E, Schimmel, Paul, Lindquist, Susan, Clardy, Jon, Mota, Maria M, Keller, Tracy L, Whitman, Malcolm, Wiest, Olaf, Wirth, Dyann F, Mazitschek, Ralph

“…The emergence of drug resistance is a major limitation of current antimalarials. The discovery of new druggable targets and pathways including those that are…”
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The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling by Fagbami, Lola, Deik, Amy A, Singh, Kritika, Santos, Sofia A, Herman, Jonathan D, Bopp, Selina E, Lukens, Amanda K, Clish, Clary B, Wirth, Dyann F, Mazitschek, Ralph

“…We have previously identified the cytoplasmic prolyl tRNA synthetase in Plasmodium falciparum as the functional target of the natural product febrifugine and…”
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malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication by Panel on Basic Science, Technologies, Enabling

“…Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions…”
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Identification of pathogen genomic variants through an integrated pipeline by Manary, Micah J, Singhakul, Suriya S, Flannery, Erika L, Bopp, Selina Er, Corey, Victoria C, Bright, Andrew Taylor, McNamara, Case W, Walker, John R, Winzeler, Elizabeth A

“…Whole-genome sequencing represents a powerful experimental tool for pathogen research. We present methods for the analysis of small eukaryotic genomes,…”
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Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum by Dharia, Neekesh V, Sidhu, Amar Bir Singh, Cassera, María Belén, Westenberger, Scott J, Bopp, Selina Er, Eastman, Rich T, Plouffe, David, Batalov, Serge, Park, Daniel J, Volkman, Sarah K, Wirth, Dyann F, Zhou, Yingyao, Fidock, David A, Winzeler, Elizabeth A

“…The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the…”
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The Adaptive Proline Response in P. falciparum Is Independent of Pf eIK1 and eIF2α Signaling by Fagbami, Lola, Deik, Amy A., Singh, Kritika, Santos, Sofia A., Herman, Jonathan D., Bopp, Selina E., Lukens, Amanda K., Clish, Clary B., Wirth, Dyann F., Mazitschek, Ralph

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Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-[gamma] as Contributing to Enhanced Malaria Survival by Bopp, Selina E. R, Ramachandran, Vandana, Henson, Kerstin, Luzader, Angelina, Lindstrom, Merle, Spooner, Muriel, Steffy, Brian M, Suzuki, Oscar, Janse, Chris, Waters, Andrew P, Zhou, Yingyao, Wiltshire, Tim, Winzeler, Elizabeth A

“…The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have…”
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Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families. e1003293 by Bopp, Selina ER, Manary, Micah J, Bright, A Taylor, Johnston, Geoffrey L, Dharia, Neekesh V, Luna, Fabio L, McCormack, Susan, Plouffe, David, McNamara, Case W, Walker, John R

“…Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses…”
Get full text

Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-g as Contributing to Enhanced Malaria Survival by Bopp, Selina ER, Ramachandran, Vandana, Henson, Kerstin, Luzader, Angelina, Lindstrom, Merle, Spooner, Muriel, Steffy, Brian M, Suzuki, Oscar, Janse, Chris, Waters, Andrew P, Zhou, Yingyao, Wiltshire, Tim, Winzeler, Elizabeth A

“…The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have…”
Get full text