Search Results - "Boping Liu"

Molecular Mechanism of Small-Molecule Inhibitors in Blocking the PD-1/PD-L1 Pathway through PD-L1 Dimerization by Guo, Yan, Jin, Yulong, Wang, Bingfeng, Liu, Boping

“…Programmed cell death-1 (PD-1), which is a molecule involved in the inhibitory signal in the immune system and is important due to blocking of the interactions…”
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Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study by Guo, Yan, Liang, Jianhuai, Liu, Boping, Jin, Yulong

“…In cancer immunotherapy, an emerging approach is to block the interactions of programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) using…”
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Approaching the Dimerization Mechanism of Small Molecule Inhibitors Targeting PD-L1 with Molecular Simulation by Liang, Jianhuai, Wang, Bingfeng, Yang, Yang, Liu, Boping, Jin, Yulong

“…Inhibitors blocking the PD-1/PD-L1 immune checkpoint demonstrate impressive anti-tumor immunity, and small molecule inhibitors disclosed by the Bristol-Myers…”
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Effect of Fragment 1 on the Binding of Epigallocatechin Gallate to the PD-L1 Dimer Explored by Molecular Dynamics by Guo, Yan, Guo, Yilin, Guo, Zichao, Liu, Boping, Xu, Jianguo

“…Blocking the interaction between programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) by directly targeting the PD-L1 dimer has emerged as…”
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Efficient cycloaddition of CO2 and epoxides to cyclic carbonates using salen-based covalent organic framework as a heterogeneous catalyst by Tong, Yutao, Cheng, Ruihua, Dong, Huan, Liu, Boping

“…Salen-based covalent organic framework (COF), constructed by salen skeleton, has great potential applications as the heterogeneous catalyst due to its unique…”
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Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats by Liu, Ruijing, Liu, Boping, Tian, Lingmin, Jiang, Xinwei, Li, Xusheng, Cai, Dongbao, Sun, Jianxia, Bai, Weibin, Jin, Yulong

“…Bisphenol A (BPA) is a globally utilized industrial chemical and is commonly used as a monomer of polycarbonate plastics and epoxy resins. Recent research…”
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Revealing the Effect of the Molecular Weight Distribution on the Chain Diffusion and Crystallization Process under a Branched Trimodal Polyethylene System by Cai, Min, He, Xuelian, Liu, Boping

“…With the increasing demand for high-end materials, trimodal polyethylene (PE) has become a research hotspot in recent years due to its superior performance…”
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Is the Triggering of PD-L1 Dimerization a Potential Mechanism for Food-Derived Small Molecules in Cancer Immunotherapy? A Study by Molecular Dynamics by Wu, Xiaoyan, Wang, Na, Liang, Jianhuai, Wang, Bingfeng, Jin, Yulong, Liu, Boping, Yang, Yang

“…Using small molecules to inhibit the PD-1/PD-L1 pathway is an important approach in cancer immunotherapy. Natural compounds such as capsaicin, zucapsaicin,…”
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Mechanistic Aspects of Acrylic Acid Formation from CO2–Ethylene Coupling over Palladium‐ and Nickel‐based Catalysts by Li, Yuanhui, Liu, Zhen, Cheng, Ruihua, Liu, Boping

“…The detailed mechanism of catalytic conversion of CO2 and ethylene to acrylic acid has been investigated through DFT and DLPNO‐CCSD(T) calculations. Four…”
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Effect of short-chain branching on the tie chains and dynamics of bimodal polyethylene: Molecular dynamics simulation by Hu, Yanling, Shao, Yunqi, Liu, Zhen, He, Xuelian, Liu, Boping

“…[Display omitted] •A modified tie chains formation mechanism is proposed to explain the SCBD effect.•SCBs distributed on the long chain provoke a delay of the…”
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Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats by Liu, Ruijing, Cai, Dongbao, Li, Xusheng, Liu, Boping, Chen, Jiali, Jiang, Xinwei, Li, Haiwei, Li, Zhenhua, Teerds, Katja, Sun, Jianxia, Bai, Weibin, Jin, Yulong

“…Bisphenol A (BPA) is an environmental endocrine disruptor. Recent studies have shown an association between decreased spermatogenesis and gut microbiota…”
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Development of a social responsibility scale for Chinese university students by Liu, Boping, Liu, Zhaoqi, Chen, Li

“…This study develops a new scale to measure Chinese university students’ social responsibility—Chinese university students’ social responsibility scale…”
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Strategic Design of Catalytic Lysine‐Targeting Reversible Covalent BCR‐ABL Inhibitors by Quach, David, Tang, Guanghui, Anantharajan, Jothi, Baburajendran, Nithya, Poulsen, Anders, Wee, John L. K., Retna, Priya, Li, Rong, Liu, Boping, Tee, Doris H. Y., Kwek, Perlyn Z., Joy, Joma K., Yang, Wan‐Qi, Zhang, Chong‐Jing, Foo, Klement, Keller, Thomas H., Yao, Shao Q.

“…Targeted covalent inhibitors have re‐emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid…”
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Effect of chain microstructure on mechanical properties of metallocene LLDPE resins by using TREF×HT-GPC and TREF×SSA methods by Long, Xuantian, Jiang, Xiaodie, Zhang, Yichen, Zhong, Linqian, Jin, Yulong, Xie, Xiaoqiong, Wu, Bo, Liu, Boping, Yang, Yang

“…Analyzing commodity metallocene linear low-density polyethylene (mLLDPE) for its chain structure and mechanical performance is crucial for developing…”
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Mechanistic DFT Study on Ethylene Trimerization of Chromium Catalysts Supported by a Versatile Pyrrole Ligand System by Yang, Yun, Liu, Zhen, Cheng, Ruihua, He, Xuelian, Liu, Boping

“…To elucidate fundamental mechanistic aspects of the landmark Chevron–Phillips ethylene trimerization system, a detailed theoretical study has been carried out…”
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A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir by Vankadara, Subramanyam, Dawson, Monique Danielle, Fong, Jia Yi, Oh, Qin Yao, Ang, Qi An, Liu, Boping, Chang, Hong Yun, Koh, Judice, Koh, Xiaoying, Tan, Qian Wen, Joy, Joma, Chia, Cheng San Brian

“…The SARS-CoV-2 pandemic is currently causing an unprecedented global health emergency since its emergence in December 2019. In December 2021, the FDA granted…”
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A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors by Vankadara, Subramanyam, Wong, Yun Xuan, Liu, Boping, See, Yi Yang, Tan, Li Hong, Tan, Qian Wen, Wang, Gang, Karuna, Ratna, Guo, Xue, Tan, Shu Ting, Fong, Jia Yi, Joy, Joma, Chia, C.S. Brian

“…[Display omitted] The COVID-19 pandemic caused by SARS-CoV-2 has created an unprecedented global health emergency. As of July 2021, only three antiviral…”
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Dominant Effects of Short-Chain Branching on the Initial Stage of Nucleation and Formation of Tie Chains for Bimodal Polyethylene as Revealed by Molecular Dynamics Simulation by Hu, Yanling, Shao, Yunqi, Liu, Zhen, He, Xuelian, Liu, Boping

“…The molecular mechanism of short-chain branching (SCB), especially the effects of methylene sequence length (MSL) and short-chain branching distribution (SCBD)…”
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Et2Zn-mediated stoichiometric C(sp)-H silylation of 1-alkynes and chlorosilanes by Huang, Pan, Xu, Dawen, Reich, Robert M., Kaiser, Felix, Liu, Boping, Kühn, Fritz E.

“…[Display omitted] •A novel one-step Et2Zn mediated silylation of 1-alkynes and chlorosilanes.•High yields and selectivity as well as well substrate tolerance…”
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Mechanistic Understanding on the Role of Cu Species over the CuOx/TiO2 Catalyst for CO2 Photoreduction by Wang, Yujie, Deng, Shiheng, Liu, Boping, Jin, Yulong

“…Incorporation of earth-abundant Cu is one of the most important approaches to improve the practicability of TiO 2 for photoreduction of CO 2 into value-added…”
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