Search Results - "Booth, Frank W."

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms by Booth, Frank W, Roberts, Christian K, Thyfault, John P, Ruegsegger, Gregory N, Toedebusch, Ryan G

“…This review proposes that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in…”
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Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits by Neufer, P. Darrell, Bamman, Marcas M., Muoio, Deborah M., Bouchard, Claude, Cooper, Dan M., Goodpaster, Bret H., Booth, Frank W., Kohrt, Wendy M., Gerszten, Robert E., Mattson, Mark P., Hepple, Russell T., Kraus, William E., Reid, Michael B., Bodine, Sue C., Jakicic, John M., Fleg, Jerome L., Williams, John P., Joseph, Lyndon, Evans, Mary, Maruvada, Padma, Rodgers, Mary, Roary, Mary, Boyce, Amanda T., Drugan, Jonelle K., Koenig, James I., Ingraham, Richard H., Krotoski, Danuta, Garcia-Cazarin, Mary, McGowan, Joan A., Laughlin, Maren R.

“…The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly…”
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Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions by Roberts, Michael D, McCarthy, John J, Hornberger, Troy A, Phillips, Stuart M, Mackey, Abigail L, Nader, Gustavo A, Boppart, Marni D, Kavazis, Andreas N, Reidy, Paul T, Ogasawara, Riki, Libardi, Cleiton A, Ugrinowitsch, Carlos, Booth, Frank W, Esser, Karyn A

“…Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have been extensively researched since the landmark report by Morpurgo (1897) of…”
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Lifetime sedentary living accelerates some aspects of secondary aging by BOOTH, Frank W, LAYE, Matthew J, ROBERTS, Michael D

“…Lifetime physical inactivity interacts with secondary aging (i.e., aging caused by diseases and environmental factors) in three patterns of response. First,…”
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The role of nucleus accumbens CREB attenuation in rescuing low voluntary running behavior in female rats by Grigsby, Kolter B., Childs, Thomas E., Booth, Frank W.

“…Given the integral role of nucleus accumbens (NAc) cAMP response element binding protein (CREB) activity in motivational processes, the goal of the current…”
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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model by Rector, R. Scott, Thyfault, John P, Uptergrove, Grace M, Morris, E. Matthew, Naples, Scott P, Borengasser, Sarah J, Mikus, Catherine R, Laye, Matthew J, Laughlin, M. Harold, Booth, Frank W, Ibdah, Jamal A

“…Background & Aims In this study, we sought to determine the temporal relationship between hepatic mitochondrial dysfunction, hepatic steatosis and insulin…”
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Endurance Exercise and the Regulation of Skeletal Muscle Metabolism by Booth, Frank W, Ruegsegger, Gregory N, Toedebusch, Ryan G, Yan, Zhen

“…Almost a half century ago, regular endurance exercise was shown to improve the capacity of skeletal muscle to oxidize substrates to produce ATP for muscle…”
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A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity by KROGH-MADSEN, Rikke, THYFAULT, John P, BROHOLM, Christa, HARTVIG MORTENSEN, Ole, OLDEN, Rasmus H, MOUNIER, Remi, PLOMGAARD, Peter, VAN HALL, Gerrit, BOOTH, Frank W, PEDERSEN, Bente K

“…US adults take between approximately 2,000 and approximately 12,000 steps per day, a wide range of ambulatory activity that at the low range could increase…”
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Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes by Ruegsegger, Gregory N, Booth, Frank W

“…Physical inactivity is a primary contributor to diseases such as obesity, cardiovascular disease, and type 2 diabetes. Accelerometry data suggest that a…”
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Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers by MIKUS, Catherine R, OBERLIN, Douglas J, LIBLA, Jessica L, TAYLOR, Angelina M, BOOTH, Frank W, THYFAULT, John P

“…Postprandial glucose (PPG) is an independent predictor of cardiovascular events and death, regardless of diabetes status. Whereas changes in physical activity…”
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Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats by Rector, R Scott, Thyfault, John P, Morris, R Tyler, Laye, Matthew J, Borengasser, Sarah J, Booth, Frank W, Ibdah, Jamal A

“…Exercise training is commonly prescribed for treatment of nonalcoholic fatty liver disease (NAFLD). We sought to determine whether exercise training prevents…”
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Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model by Rector, R Scott, Uptergrove, Grace M, Morris, E Matthew, Borengasser, Sarah J, Laughlin, M Harold, Booth, Frank W, Thyfault, John P, Ibdah, Jamal A

“…The maintenance of normal body weight either through dietary modification or being habitually more physically active is associated with reduced incidence of…”
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Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior by Grigsby, Kolter B., Ruegsegger, Gregory N., Childs, Thomas E., Booth, Frank W.

“…A gene was sought that could reverse low voluntary running distances in a model of low voluntary wheel-running behavior. In order to confirm the low motivation…”
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Creatine Supplementation Upregulates mTORC1 Signaling and Markers of Synaptic Plasticity in the Dentate Gyrus While Ameliorating LPS-Induced Cognitive Impairment in Female Rats by Mao, Xuansong, Kelty, Taylor J., Kerr, Nathan R., Childs, Thomas E., Roberts, Michael D., Booth, Frank W.

“…Mild cognitive impairment (MCI) designates the boundary area between cognitive function in natural aging and dementia, and this is viewed as a therapeutic…”
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Lack of regular physical exercise or too much inactivity by Thyfault, John P, Booth, Frank W

“…PURPOSE OF REVIEWTo discuss the current data that acute periods of physical inactivity are harmful to health. RECENT FINDINGSBed rest prescribed for recovery…”
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Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function by Kerr, Nathan R, Kelty, Taylor J, Mao, Xuansong, Childs, Thomas E, Kline, David D, Rector, R Scott, Booth, Frank W

“…Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer's Disease (AD)…”
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Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running by Ruegsegger, Gregory N, Brown, Jacob D, Cathleen Kovarik, M, Miller, Dennis K, Booth, Frank W

“…Highlights • Intrinsic Oprm1 function was increased in the NAc of HVR compared to LVR rats. • Intraperitoneal naltrexone reduced dopamine-related mRNAs,…”
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Lack of exercise is a major cause of chronic diseases by Booth, Frank W, Roberts, Christian K, Laye, Matthew J

“…Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article…”
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Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet–Fed Female Mice by Padilla, Jaume, Ramirez-Perez, Francisco I, Habibi, Javad, Bostick, Brian, Aroor, Annayya R, Hayden, Melvin R, Jia, Guanghong, Garro, Mona, DeMarco, Vincent G, Manrique, Camila, Booth, Frank W, Martinez-Lemus, Luis A, Sowers, James R

“…We recently showed that Western diet–induced obesity and insulin resistance promotes endothelial cortical stiffness in young female mice. Herein, we tested the…”
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Aerobic exercise training in the treatment of non‐alcoholic fatty liver disease related fibrosis by Linden, Melissa A., Sheldon, Ryan D., Meers, Grace M., Ortinau, Laura C., Morris, E. Matthew, Booth, Frank W., Kanaley, Jill A., Vieira‐Potter, Victoria J., Sowers, James R., Ibdah, Jamal A., Thyfault, John P., Laughlin, M. Harold, Rector, R. Scott

“…Key points Physiologically relevant rodent models of non‐alcoholic steatohepatitis (NASH) that resemble the human condition are limited. Exercise training and…”
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