Search Results - "Booth, Bruce L"

This time may be different by Booth, Bruce L

“…The markets may be softening on biotech, but overall the sector remains in an incredibly strong environment…”
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Beyond the biotech IPO: a brave new world by Booth, Bruce L

“…After a decade of significant challenges, biotech's long-term sustainability depends on making fundamental changes to its traditional business model…”
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In defense of life sciences venture investing by Booth, Bruce L, Salehizadeh, Bijan

“…Contrary to widely held perceptions, data on venture returns show that life sciences startups have outperformed other sectors over the past decade…”
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When less is more by Booth, Bruce L

“…Investors are pouring cash into biotech companies today at a pace near historic highs. However, an analysis of recent returns from venture-backed biotech firms…”
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Early-stage returns? by Booth, Bruce L

“…Contrary to conventional thinking, there are compelling reasons for investors to consider early-stage life science ventures, especially in the context of a…”
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An Inhibitor of HIV-1 Protease Modulates Proteasome Activity, Antigen Presentation, and T Cell Responses by Andre, Patrice, Groettrup, Marcus, Klenerman, Paul, De Giuli, Rita, Booth, Bruce L., Cerundolo, Vincenzo, Bonneville, Marc, Jotereau, Francine, Zinkernagel, Rolf M., Lotteau, Vincent

“…Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease…”
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CD8+ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef by Milicic, Anita, Price, David A, Zimbwa, Peter, Booth, Bruce L, Brown, Helen L, Easterbrook, Philippa J, Olsen, Kara, Robinson, Nicola, Gileadi, Uzi, Sewell, Andrew K, Cerundolo, Vincenzo, Phillips, Rodney E

“…CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL…”
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Valuation with cash multiples by Booth, Bruce L

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Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes by Sewell, Andrew K, Booth, Jr, Bruce L, Cerundolo, Vincenzo, Phillips, Rodney E, Price, David A

“…Cytotoxic T lymphocytes (CTLs) play a key role in the control of persistent viral infections. Differences in the quality of this cellular immune response…”
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Generation of an Immunodominant CTL Epitope Is Affected by Proteasome Subunit Composition and Stability of the Antigenic Protein by Gileadi, Uzi, Moins-Teisserenc, Helene T, Correa, Isabel, Booth, Bruce L., Jr, Dunbar, P. Rod, Sewell, Andrew K, Trowsdale, John, Phillips, Rodney E, Cerundolo, Vincenzo

“…Generation of the HLA-A0201 (A2) influenza Matrix 58-66 epitope contained within the full-length Matrix protein is impaired in cells lacking the proteasome…”
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Erratum: In defense of life sciences venture investing by Booth, Bruce L, Salehizadeh, Bijan

“…Nat. Biotechnol. 29, 579–583 (2011); published online 11 July 2011; corrected after print 11 July 2011 In the version of this article initially published, the…”
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In defense of life sciences venture investing: contrary to widely held perceptions, data on venture returns show that life sciences startups have outperformed other sectors over the past decade by Booth, Bruce L, Salehizadeh, Bijan

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Extensive Alanine Substitutions Increase Binding Affinity of an Influenza Nucleoprotein Peptide to HLA-Aw68 and Do Not Abrogate Peptide-Specific CTL Recognition by Collins, Edward J, Booth, Bruce L., Jr, Cerundolo, Vincenzo

“…Class I MHC molecules bind peptides in the endoplasmic reticulum and present them at the cell surface to circulating CD8+ T cells for analysis. We have…”
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Beyond the biotech IPO: a brave new world; after a decade of significant challenges, biotech's long-term sustainability depends on making fundamental changes to its traditional business model by Booth, Bruce L

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Identification and characterization of a nuclease specific for the 3' end of the U6 small nuclear RNA by Booth, Jr, B L, Pugh, B F

“…The U6 small nuclear RNA is post-transcriptionally processed by the addition and removal of nontemplate uridylates (Us) at its 3' end prior to incorporation…”
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Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes by Kelleher, A D, Booth, Jr, B L, Sewell, A K, Oxenius, A, Cerundolo, V, McMichael, A J, Phillips, R E, Price, D A

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Polymeric waveguides by Sullivan, C.T., Booth, B.L., Husain, A.

“…Techniques for fabricating polymeric waveguides, which are of growing interest for telecommunications, data communications, and optical interconnects within…”
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Cytotoxic T lymphocytes, chemokines and antiviral immunity by Price, David A, Klenerman, Paul, Booth, Bruce L, Phillips, Rodney E, Sewell, Andrew K

“…Evidence that CD8 + CTLs produce chemokines following engagement of viral antigens, and that MIP-1α is required for an inflammatory response to virus…”
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Low loss channel waveguides in polymers by Booth, B.L.

“…The primary routes for creating polymeric channel waveguides are reviewed. Processes, materials, waveguide performance, and applications recently reported in…”
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CD8 super(+) T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef by Milicic, Anita, Price, David A, Zimbwa, Peter, Booth, Bruce L, Brown, Helen L, Easterbrook, Philippa J, Olsen, Kara, Robinson, Nicola, Gileadi, Uzi, Sewell, Andrew K, Cerundolo, Vincenzo, Phillips, Rodney E

“…CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL…”
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