Search Results - "Boot, J.R."

The effect of calcium channel modulators on blood pressure and pressor responses to noradrenaline in the guinea-pig by Bond, A, Boot, J R

“…Selective L-type voltage-operated calcium channel (VOCC) antagonists nicardipine, diltiazem and verapamil all produced pronounced falls in mean arterial blood…”
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Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake by BOOT, J. R, BRACE, G, RATHMELL, R. E, RICHARDS, S. J, SIMMONDS, R. G, WALLACE, L, WHATTON, M. A, DELATOUR, C. L, DEZUTTER, N, FAIRHURST, J, FINDLAY, J, GALLAGHER, P. T, HOES, I, MAHADEVAN, S, MITCHELL, S. N

“…A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake…”
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N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake by Boot, J.R., Boulet, S.L., Clark, B.P., Cases-Thomas, M.J., Delhaye, L., Diker, K., Fairhurst, J., Findlay, J., Gallagher, P.T., Gilmore, J., Harris, J.R., Masters, J.J., Mitchell, S.N., Naik, M., Simmonds, R.G., Smith, S.M., Richards, S.J., Timms, G.H., Whatton, M.A., Wolfe, C.N., Wood, V.A.

“…A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A…”
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The pharmacological evaluation of LY170680, a novel leukotriene D 4 and E 4 antagonist in the guinea‐pig by Boot, J.R., Bond, A., Gooderham, R., O'Brien, A., Parsons, M., Thomas, K.H.

“…This paper describes the evaluation of LY170680 (5‐<3‐[2(R) (carboxyethylthio)‐1(S)‐hydroxypentadeca 3(E)5(Z)‐dienyl]phenyl > 1H tetrazole, as an antagonist of…”
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The pharmacological evaluation of LY170680, a novel leukotriene D4 and E4 antagonist in the guinea‐pig by Boot, J.R., Bond, A., Gooderham, R., O'Brien, A., Parsons, M., Thomas, K.H.

“…1 This paper describes the evaluation of LY170680 (5‐<3‐[2(R) (carboxyethylthio)‐1(S)‐hydroxypentadeca 3(E)5(Z)‐dienyl]phenyl > 1H tetrazole, as an antagonist…”
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The relationship between development of lung inflammation and changes in bone marrow populations in guinea-pigs following inhaled antigen challenge by Barton, H J, Bond, A, Boot, J R, Brandon, D R, O'Brien, A

“…Sensitised guinea-pigs were exposed to aerosolised antigen. The resultant cellular infiltration into the lung was assessed in lung tissue and bronchoalveolar…”
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The pharmacology of N-methyl LTC4; a metabolically stable LTC4-mimetic by Baker, S R, Boot, J R, Gooderham, R, O'Brien, A, Thomas, K H, Ward, M, Woodhouse, S

“…N-methyl LTC4 (NMLTC4) a synthetic analogue of LTC4, has been shown not to be a substrate for gamma-glutamyl transpeptidase. NMLTC4 produced contractions of…”
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The anti-allergic activity of Benoxaprofen [2-(4-chlorophenyl)-alpha-methyl-5-benzoxazole acetic acid]--a lipoxygenase inhibitor by Boot, J R, Sweatman, W J, Cox, B A, Stone, K, Dawson, W

“…Benoxaprofen [2-(4-chlorophenyl)-alpha-methyl-5-benzoxazole acetic acid], a novel anti-inflammatory compound, is also an orally-active anti-allergic compound…”
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Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes by Kitchen, E A, Boot, J R, Dawson, W

“…(1) The chemotactic activities of thromboxane B2 (TxB2), PGE2, PGF2alpha, the 15-oxo, 15-oxo-13,14-dihydro and 13,14-dihydro metabolites of PGE2, PGF2alpha,…”
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The pharmacology of prostaglandin-like substances released from guinea-pig lungs during anaphylaxis by Boot, J R, Dawson, W, Cockerill, A F, Mallen, D N, Osborne, D J

“…The pharmacology of the prostaglandins (PGs) and thromboxanes (Txs) released from immunologically challenged guinea-pig lungs is related to their roles in the…”
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PGE1 metabolism by the perfused rat liver by Osborne, D J, Boot, J R, Cockerill, A F, Cranstone, K G, Dawson, W, Harvey, J, Mallen, D N, Smith, C W

“…The hepatic and biliary metabolites of PGE1 have been isolated and identified after infusions of PGE1 into isolated rat liver preparations. The results…”
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Synthesis of two PGE2 human urinary metabolites by Boot, J R, Foulis, M J, Gutteridge, N J, Smith, C W

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