Search Results - "Boorstein, Robert J."

Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights by Nagy-Szakal, Dorottya, Couto-Rodriguez, Mara, Wells, Heather L, Barrows, Joseph E, Debieu, Marilyne, Butcher, Kristin, Chen, Siyuan, Berki, Agnes, Hager, Courteny, Boorstein, Robert J, Taylor, Mariah K, Jonsson, Colleen B, Mason, Christopher E, O’Hara, Niamh B

“…The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic variants that may alter viral fitness highlights the urgency of…”
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Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity by Ocampo, Maria T. A., Chaung, Wenren, Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis–trans epimerization by Ocampo-Hafalla, Maria T., Altamirano, Alvin, Basu, Ashis K., Chan, Michael K., Ocampo, Jose Eliseo A., Cummings, Archie, Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Oxidation of thymine yields 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol. Tg) which, as cis 5S,6R and 5R,6S 2’-deoxyribonucleoside diastereoisomers (dTg1,…”
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Purification of a Mammalian Homologue of Escherichia coli Endonuclease III:  Identification of a Bovine Pyrimidine Hydrate-Thymine Glycol DNA-Glycosylase/AP Lyase by Irreversible Cross Linking to a Thymine Glycol-Containing Oligodeoxynucleotide by Hilbert, Timothy P, Boorstein, Robert J, Kung, Hsiang Chuan, Bolton, Philip H, Xing, Dongxia, Cunningham, Richard P, Teebor, George W

“…We purified a homologue of the Escherichia coli DNA repair enzyme endonuclease III 5000-fold from calf thymus which, like endonuclease III, demonstrates…”
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Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity by Marenstein, Dina R, Chan, Michael K, Altamirano, Alvin, Basu, Ashis K, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…Base excision repair of oxidized pyrimidines in human DNA is initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the…”
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Definitive Identification of Mammalian 5-Hydroxymethyluracil DNA N-Glycosylase Activity as SMUG1 by Boorstein, Robert J., Archie, Cummings, Marenstein, Dina R., Chan, Michael K., Ma, Yuliang, Neubert, Thomas A., Brown, Stuart M., Teebor, George W.

“…Purification from calf thymus of a DNA N-glycosylase activity (HMUDG) that released 5-hydroxymethyluracil (5hmUra) from the DNA of Bacillus subtilis phage SPO1…”
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Cloning and Expression of the cDNA Encoding the Human Homologue of the DNA Repair Enzyme, Escherichia coli Endonuclease III by Hilbert, Timothy P., Chaung, Wenren, Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…We previously purified a bovine pyrimidine hydrate-thymine glycol DNA glycosylase/AP lyase. The amino acid sequence of tryptic bovine peptides was homologous…”
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Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis by Ulbert, Sebastian, Cross, Mike, Boorstein, Robert J., Teebor, George W., Borst, Piet

“…In kinetoplastid flagellates such as Trypanosoma brucei, a small percentage of the thymine residues in the nuclear DNA is replaced by the modified base…”
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Substrate Specificity of Human Endonuclease III (hNTH1) by Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Base excision repair of oxidized pyrimidines in human DNA is initiated by the DNA N -glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the…”
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Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53 by Mi, Li-Jun, Chaung, Wenren, Horowitz, Robert, Teebor, George W., Boorstein, Robert J.

“…We have demonstrated previously that the toxicity of 5-hydroxymethyl-2′-deoxyuridine (hmdUrd) to Chinese hamster fibroblasts (V79 cells) results from enzymatic…”
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The repairability of oxidative free radical mediated damage to DNA: a review by Teebor, G W, Boorstein, R J, Cadet, J

“…Many DNA repair enzyme activities are present in both prokaryotic and eukaryotic organisms. Among these are DNA exo- and endonucleases and DNA glycosylases…”
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Formation and stability of repairable pyrimidine photohydrates in DNA by Boorstein, Robert J, Hilbert, Timothy P, Cunningham, Richard P, Teebor, George W

“…Ultraviolet irradiation of poly(dG-dC) and poly(dA-dU) in solution produces pyrimidine hydrates that are repaired by bacterial and mammalian DNA glycosylases…”
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Lack of phenotypic alteration of hmUra-DNA glycosylase-deficient hamster cells exposed to DNA-damaging agents by Mi, L J, Mahl, E, Chaung, W, Boorstein, R J

“…V79mut1 cells are resistant to the toxic effects of 5-hydroxymethyl-2'-deoxyuridine (hmdUrd) and are deficient in the DNA repair enzyme hydroxymethyluracil-DNA…”
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Effect of pH and Temperature on the Stability of UV-Induced Repairable Pyrimidine Hydrates in DNA by O'Donnell, Robert E, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…UV irradiation of cytosine yields 6-hydroxy-5,6-dihydrocytosine (cytosine hydrate) whether the cytosine is in solution as base, nucleoside, or nucleotide or on…”
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Comparison of the Effects of UV Irradiation on 5-Methyl-Substituted and Unsubstituted Pyrimidines in Alternating Pyrimidine-Purine Sequences in DNA by Zuo, Shaojun, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…We previously demonstrated the UV-induced formation of cytosine hydrate in DNA and its deamination product, uracil hydrate, via their release from the DNA…”
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UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities by Boorstein, Robert J, Hilbert, Timothy P, Cadet, Jean, Cunningham, Richard P, Teebor, George W

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Mutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells by BOORSTEIN, R. J, TEEBOR, G. W

“…5-Hydroxymethyluracil (HmUra) is formed from thymine in DNA through the action of ionizing radiation or reactive oxygen species generated by activated…”
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Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells by BOORSTEIN, R. J, TEEBOR, G. W

“…5-Hydroxymethyl-2'-deoxyuridine (HmdUrd), a cytotoxic analogue of thymidine, has been proposed for use as an anticancer agent. HmdUrd is incorporated into DNA…”
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Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor by Marenstein, D R, Ocampo, M T, Chan, M K, Altamirano, A, Basu, A K, Boorstein, R J, Cunningham, R P, Teebor, G W

“…Human endonuclease III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic (AP) lyase that initiates base excision repair of pyrimidines modified by reactive…”
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Toxicity of 3-aminobenzamide to Chinese hamster cells containing 5-hydroxymethyluracil in their DNA by BOORSTEIN, R. J, LEVY, D. D, TEEBOR, G. W

“…V79 cells incorporated 5-hydroxymethyl-2'-deoxyuridine (HmdUrd) into their DNA linearly over a wide range of concentrations and time. Cells grew normally when…”
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