Search Results - "Boopathy, Archana"

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination by Boopathy, Archana V., Mandal, Anasuya, Kulp, Daniel W., Menis, Sergey, Bennett, Nitasha R., Watkins, Hannah C., Wang, Wade, Martin, Jacob T., Thai, Nikki T., He, Yanpu, Schief, William R., Hammond, Paula T., Irvine, Darrell J.

“…Sustained exposure of lymphoid tissues to vaccine antigens promotes humoral immunity, but traditional bolus immunizations lead to rapid antigen clearance. We…”
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Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles by Stinson, Jordan A., Boopathy, Archana V., Cieslewicz, Brian M., Zhang, Yichen, Hartman, Nickolas W., Miller, David P., Dirckx, Matthew, Hurst, Brett L., Tarbet, E. Bart, Kluge, Jonathan A., Kosuda, Kathryn M.

“…•Infection mimicry enhances humoral and cellular immune responses to flu vaccine.•Silk microneedle patches achieve influenza vaccine release for 2 weeks in…”
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Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats by Salimath, Apoorva S, Phelps, Edward A, Boopathy, Archana V, Che, Pao-lin, Brown, Milton, García, Andrés J, Davis, Michael E

“…Acute myocardial infarction (MI) caused by ischemia and reperfusion (IR) is the most common cause of cardiac dysfunction due to local cell death and a…”
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Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction by Somasuntharam, Inthirai, Boopathy, Archana V, Khan, Raffay S, Martinez, Mario D, Brown, Milton E, Murthy, Niren, Davis, Michael E

“…Abstract Myocardial infarction (MI) is the most common cause of heart failure (HF), the leading cause of death in the developed world. Oxidative stress due to…”
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A naturally derived cardiac extracellular matrix enhances cardiac progenitor cell behavior in vitro by French, Kristin M., Boopathy, Archana V., DeQuach, Jessica A., Chingozha, Loice, Lu, Hang, Christman, Karen L., Davis, Michael E.

“…Myocardial infarction (MI) produces a collagen scar, altering the local microenvironment and impeding cardiac function. Cell therapy is a promising therapeutic…”
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Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization by Havenar-Daughton, Colin, Carnathan, Diane G., Boopathy, Archana V., Upadhyay, Amit A., Murrell, Ben, Reiss, Samantha M., Enemuo, Chiamaka A., Gebru, Etse H., Choe, Yury, Dhadvai, Pallavi, Viviano, Federico, Kaushik, Kirti, Bhiman, Jinal N., Briney, Bryan, Burton, Dennis R., Bosinger, Steven E., Schief, William R., Irvine, Darrell J., Silvestri, Guido, Crotty, Shane

“…The first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of…”
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Intramyocardial Delivery of Notch Ligand-Containing Hydrogels Improves Cardiac Function and Angiogenesis Following Infarction by Boopathy, Archana V, Martinez, Mario D, Smith, Amanda Walker, Brown, Milton E, García, Andrés J, Davis, Michael E

“…Myocardial infarction (MI) is the leading cause of death worldwide. Notch1 signaling plays a critical role in cardiac development, in survival, cardiogenic…”
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Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells by Boopathy, Archana V, Pendergrass, Karl D, Che, Pao Lin, Yoon, Young-Sup, Davis, Michael E

“…Administration of bone marrow-derived mesenchymal stem cells (MSCs) after myocardial infarction (MI) results in modest functional improvements. However; the…”
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Age‐Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure by Agarwal, Udit, Smith, Amanda W., French, Kristin M., Boopathy, Archana V., George, Alex, Trac, David, Brown, Milton E., Shen, Ming, Jiang, Rong, Fernandez, Janet D., Kogon, Brian E., Kanter, Kirk R., Alsoufi, Baahaldin, Wagner, Mary B., Platt, Manu O., Davis, Michael E.

“…To investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling, the authors injected neonate, infant, or child…”
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The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation by Boopathy, Archana V, Che, Pao Lin, Somasuntharam, Inthirai, Fiore, Vincent F, Cabigas, E. Bernadette, Ban, Kiwon, Brown, Milton E, Narui, Yoshie, Barker, Thomas H, Yoon, Young-Sup, Salaita, Khalid, García, Andrés J, Davis, Michael E

“…Abstract Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown…”
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Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys by Boopathy, Archana V., Sharma, Bhawna, Nekkalapudi, Anurag, Wimmer, Raphaela, Gamez-Guerrero, Maria, Suthram, Silpa, Truong, Hoa, Lee, Johnny, Li, Jiani, Martin, Ross, Blair, Wade, Geleziunas, Romas, Orlinger, Klaus, Ahmadi-Erber, Sarah, Lauterbach, Henning, Makadzange, Tariro, Falkard, Brie, Schmidt, Sarah

“…HIV affects more than 38 million people worldwide. Although HIV can be effectively treated by lifelong combination antiretroviral therapy, only a handful of…”
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Acute preconditioning of cardiac progenitor cells with hydrogen peroxide enhances angiogenic pathways following ischemia-reperfusion injury by Pendergrass, Karl D, Boopathy, Archana V, Seshadri, Gokulakrishnan, Maiellaro-Rafferty, Kathryn, Che, Pao Lin, Brown, Milton E, Davis, Michael E

“…There are a limited number of therapies available to prevent heart failure following myocardial infarction. One novel therapy that is currently being pursued…”
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Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches by Pauthner, Matthias, Havenar-Daughton, Colin, Sok, Devin, Nkolola, Joseph P., Bastidas, Raiza, Boopathy, Archana V., Carnathan, Diane G., Chandrashekar, Abishek, Cirelli, Kimberly M., Cottrell, Christopher A., Eroshkin, Alexey M., Guenaga, Javier, Kaushik, Kirti, Kulp, Daniel W., Liu, Jinyan, McCoy, Laura E., Oom, Aaron L., Ozorowski, Gabriel, Post, Kai W., Sharma, Shailendra K., Steichen, Jon M., de Taeye, Steven W., Tokatlian, Talar, Torrents de la Peña, Alba, Butera, Salvatore T., LaBranche, Celia C., Montefiori, David C., Silvestri, Guido, Wilson, Ian A., Irvine, Darrell J., Sanders, Rogier W., Schief, William R., Ward, Andrew B., Wyatt, Richard T., Barouch, Dan H., Crotty, Shane, Burton, Dennis R.

“…The development of stabilized recombinant HIV envelope trimers that mimic the virion surface molecule has increased enthusiasm for a neutralizing antibody…”
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Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates by Sharma, Bhawna, Bekerman, Elena, Truong, Hoa, Lee, Johnny, Gamez-Guerrero, Maria, Boopathy, Archana, Mital, Rohit, Huang, Katell Bidet, Ahmadi-Erber, Sarah, Wimmer, Raphaela, Schulha, Sophie, Lauterbach, Henning, Orlinger, Klaus, Suthram, Silpa, Lewis, Mark G, Blair, Wade, Makadzange, Tariro, Geleziunas, Romas, Murry, Jeffrey P, Schmidt, Sarah

“…Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the…”
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Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase by Seshadri, Gokulakrishnan, Che, Pao Lin, Boopathy, Archana V, Davis, Michael E

“…Transplantation of cardiac progenitor cells (CPCs) is currently in early clinical testing as a potential therapeutic strategy. Superoxide is increased in the…”
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Dysregulation of catalase activity in newborn myocytes during hypoxia is mediated by c-Abl tyrosine kinase by Cabigas, E Bernadette, Liu, Jie, Boopathy, Archana V, Che, Pao Lin, Crawford, Brian H, Baroi, Gitangali, Bhutani, Srishti, Shen, Ming, Wagner, Mary B, Davis, Michael E

“…In the adult heart, catalase (CAT) activity increases appropriately with increasing levels of hydrogen peroxide, conferring cardioprotection. This mechanism is…”
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Self-assembling peptide-based delivery of therapeutics for myocardial infarction by Boopathy, Archana V, Davis, Michael E

“…Drug and cell delivery systems could be modulated to serve as instructive microenvironments in regenerative medicine. Towards this end, several synthetic…”
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Rapid HIV‐1 genotyping assay for the detection of capsid mutations by Margot, Nicolas, Naik, Vidula, Nekkalapudi, Anurag, Boopathy, Archana, Falkard, Brie, Callebaut, Christian

“…Human immunodeficiency virus (HIV) capsid is one of the most recent viral proteins successfully targeted for the development of antiretrovirals. Lenacapavir is…”
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Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques by Boopathy, Archana Vidya, Nekkalapudi, Anurag, Sung, Janette, Schulha, Sophie, Jin, Debi, Sharma, Bhawna, Ng, Sarah, Lu, Sabrina, Wimmer, Raphaela, Suthram, Silpa, Ahmadi-Erber, Sarah, Lauterbach, Henning, Orlinger, Klaus K, Hung, Magdeleine, Carr, Brian, Callebaut, Christian, Geleziunas, Romas, Kuhne, Michelle, Schmidt, Sarah, Falkard, Brie

“…Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in…”
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Sustained delivery of a HIV subunit vaccine using silk microneedle skin patches by Boopathy, Archana Vidya, Mandal, Anasuya, Kulp, Dan W, Kumari, Sudha, Wang, Wade, He, Yanpu, Tokatlian, Talar, Schief, William R, Hammond, Paula T, Irvine, Darrell J

“…Abstract Many broadly neutralizing antibodies (bNAbs) against HIV exhibit high degrees of somatic hypermutation, suggesting that immunization approaches…”
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