Anti-depressant and anti-nociceptive effects of 1,4-benzodiazepine-2-ones based cholecystokinin (CCK(2)) antagonists

Various 1,4-benzodiazepines were synthesized around a Diazepam, Oxazepam and the n-propyl-1,4-benzodiazepine template. SAR studies of CCK(2) binding affinity were performed and selected examples of each series were tested in vivo in mice. In addition to an anxiolytic effect, antidepressant effects w...

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Bibliographic Details
Published in:	Drug discoveries & therapeutics Vol. 1; no. 1; pp. 45 - 56
Main Authors:	Lattmann, E, Sattayasai, J, Lattmann, P, Billington, D C, Schwalbe, C H, Boonprakob, J, Airarat, W, Singh, H, Offel, M, Staaf, A
Format:	Journal Article
Language:	English
Published:	Japan 01-08-2007
Online Access:	Get full text
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Summary:	Various 1,4-benzodiazepines were synthesized around a Diazepam, Oxazepam and the n-propyl-1,4-benzodiazepine template. SAR studies of CCK(2) binding affinity were performed and selected examples of each series were tested in vivo in mice. In addition to an anxiolytic effect, antidepressant effects were discovered using 8 standard CNS assays in mice. Finally, the cocomittant administration of the 1,4-benzodiazepine based CCK antagonists enhanced the response to pain with a low dose of morphine, significantly.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1881-7831