Search Results - "Boone, David N."

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation by Farabaugh, Susan M, Boone, David N, Lee, Adrian V

“…Insulin-like growth factor (IGF) signaling is fundamental for growth and survival. A large body of evidence (laboratory, epidemiological, and clinical)…”
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Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors by Nagle, Alison M, Levine, Kevin M, Tasdemir, Nilgun, Scott, Julie A, Burlbaugh, Kara, Kehm, Justin, Katz, Tiffany A, Boone, David N, Jacobsen, Britta M, Atkinson, Jennifer M, Oesterreich, Steffi, Lee, Adrian V

“…Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified…”
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Egr1 mediates p53-independent c-Myc—induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism by Boone, David N., Qi, Ying, Li, Zhaoliang, Hann, Stephen R., Bister, Klaus

“…c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor…”
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Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types by Onuchic, Vitor, Hartmaier, Ryan J., Boone, David N., Samuels, Michael L., Patel, Ronak Y., White, Wendy M., Garovic, Vesna D., Oesterreich, Steffi, Roth, Matt E., Lee, Adrian V., Milosavljevic, Aleksandar

“…Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type…”
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Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling by Boone, David N, Lee, Adrian V

“…Overwhelming evidence implicates insulin-like growth factor (IGF) signaling in the growth and survival of many types of human cancer cells. Numerous inhibitors…”
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Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity by Zhang, Qin, Spears, Erick, Boone, David N., Li, Zhaoliang, Gregory, Mark A., Hann, Stephen R.

“…The oncogenic transcription factor c-Myc causes transformation and tumorigenesis, but it can also induce apoptotic cell death. Although tumor suppressors are…”
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The platypus is in its place: nuclear genes and indels confirm the sister group relation of monotremes and Therians by van Rheede, Teun, Bastiaans, Trijntje, Boone, David N, Hedges, S Blair, de Jong, Wilfried W, Madsen, Ole

“…Morphological data supports monotremes as the sister group of Theria (extant marsupials + eutherians), but phylogenetic analyses of 12 mitochondrial…”
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The Myc-ARF-Egr1 pathway: Unleashing the apoptotic power of c-Myc by Boone, David N., Hann, Stephen R.

“…Comment on: Boone DN, et al. Proc Natl Acad Sci USA 2010; 108:632-7…”
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SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation by Boone, David N., Warburton, Andrew, Som, Sreeroopa, Lee, Adrian V.

“…Evidence suggests Insulin-like growth factor 1 (IGF1) signaling is involved in the initiation and progression of a subset of breast cancers by inducing cell…”
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Computer Science, Biology and Biomedical Informatics Academy: Outcomes from 5 Years of Immersing High-school Students into Informatics Research by King, Andrew J., Fisher, Arielle M., Becich, Michael J., Boone, David N.

“…The University of Pittsburgh's Department of Biomedical Informatics and Division of Pathology Informatics created a Science, Technology, Engineering, and…”
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Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors by Chen, Jingci, Nagle, Alison M., Wang, Yu-Fen, Boone, David N., Lee, Adrian V.

“…Breast cancer development and progression are influenced by insulin-like growth factor receptor 1 (IGF1R) and insulin receptor (InsR) signaling, which drive…”
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RNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases by Heim, Tanya E., Hankins, Margaret L., Belayneh, Rebekah, Douglas, Nerone, Dinh, Vu, Kovvur, Murali, Boone, David N., Ukani, Vrutika, Bhogal, Sumail, Patel, Vaidehi, Moniz, Taylor M. A., Bailey, Kelly M., John, Ivy, Schoedel, Karen, Weiss, Kurt R., Watters, Rebecca J.

“…One-third of pediatric patients with osteosarcoma (OS) develop lung metastases (LM), which is the primary predictor of mortality. While current treatments of…”
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Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer by Warburton, Andrew J., Boone, David N.

“…Purpose of Review The goal of this review was to compare and contrast the results and implications from several recent transcriptomic studies that analyzed the…”
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Abstract 3861: Associations of intragenic rearrangement burden with immune cell infiltration and response to immune checkpoint blockade in cancer by Zhang, Han, Lee, Sanghoon, Muthakana, Renee R., Lu, Binfeng, Boone, David N, Lee, Daniel, Wang, Xiaosong

“…Abstract While immune checkpoint blockade (ICB) induces durable cancer remission, only a small subset of patients can receive benefits, whereas a substantial…”
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