Search Results - "Boon, Thierry"

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases by CIPPONI, Arcadi, MERCIER, Marjorie, SEREMET, Teofila, BAURAIN, Jean-François, THEATE, Ivan, VAN DEN OORD, Joost, STAS, Marguerite, BOON, Thierry, COULIE, Pierre G, VAN BAREN, Nicolas

“…Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course…”
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Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases by CORBIERE, Véronique, CHAPIRO, Jacques, STROOBANT, Vincent, WENBIN MA, LURQUIN, Christophe, LETHE, Bernard, VAN BAREN, Nicolas, VAN DEN EYNDE, Benoît J, BOON, Thierry, COULIE, Pierre G

“…A core challenge in cancer immunotherapy is to understand the basis for efficacious vaccine responses in human patients. In previous work we identified a…”
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Promoter-Dependent Mechanism Leading to Selective Hypomethylation within the 5′ Region of Gene MAGE-A1 in Tumor Cells by De Smet, Charles, Loriot, Axelle, Boon, Thierry

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Myc represses transcription through recruitment of DNA methyltransferase corepressor by Brenner, Carmen, Deplus, Rachel, Didelot, Céline, Loriot, Axelle, Viré, Emmanuelle, De Smet, Charles, Gutierrez, Arantxa, Danovi, Davide, Bernard, David, Boon, Thierry, Giuseppe Pelicci, Pier, Amati, Bruno, Kouzarides, Tony, de Launoit, Yvan, Di Croce, Luciano, Fuks, François

“…The Myc transcription factor is an essential mediator of cell growth and proliferation through its ability to both positively and negatively regulate…”
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DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter by De Smet, Charles, Lurquin, Christophe, Lethé, Bernard, Martelange, Valérie, Boon, Thierry

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An Antigenic Peptide Produced by Peptide Splicing in the Proteasome by Vigneron, Nathalie, Stroobant, Vincent, Chapiro, Jacques, Ooms, Annie, Degiovanni, Gérard, Morel, Sandra, van der Bruggen, Pierre, Boon, Thierry, Van den Eynde, Benoît J.

“…CD8 T lymphocytes recognize peptides of 8 to 10 amino acids presented by class I molecules of the major histocompatibility complex. Here, CD8 T lymphocytes…”
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Comparison of stable human Treg and Th clones by transcriptional profiling by Stockis, Julie, Fink, Wolfram, François, Violaine, Connerotte, Thierry, de Smet, Charles, Knoops, Laurent, van der Bruggen, Pierre, Boon, Thierry, Coulie, Pierre G, Lucas, Sophie

“…From cancerous and non-cancerous patients, we derived stable clones of CD4⁺ Treg, defined as clones that expressed high CD25 at rest, were anergic in vitro,…”
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Transient Down-regulation of DNMT1 Methyltransferase Leads to Activation and Stable Hypomethylation of MAGE-A1 in Melanoma Cells by Loriot, Axelle, De Plaen, Etienne, Boon, Thierry, De Smet, Charles

“…MAGE-A1 belongs to a group of germ line-specific genes that rely primarily on DNA methylation for repression in somatic tissues. In many types of tumors, the…”
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Correlation between Tumor Regression and T Cell Responses in Melanoma Patients Vaccinated with a MAGE Antigen by Lonchay, Christophe, van der Bruggen, Pierre, Connerotte, Thierry, Hanagiri, Takeshi, Coulie, Pierre, Colau, Didier, Lucas, Sophie, Van Pel, Aline, Thielemans, Kris, van Baren, Nicolas, Boon, Thierry

“…The cancer-germline gene MAGE-3 codes for tumor-specific antigens recognized on many tumors by T lymphocytes. A MAGE-3 antigen presented by HLA-A1 has been…”
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A Monoclonal Cytolytic T-Lymphocyte Response Observed in a Melanoma Patient Vaccinated with a Tumor-Specific Antigenic Peptide Encoded by Gene MAGE-3 by Coulie, Pierre G., Karanikas, Vaios, Colau, Didier, Lurquin, Christophe, Landry, Claire, Marchand, Marie, Dorval, Thierry, Brichard, Vincent, Boon, Thierry

“…Vaccination of melanoma patients with tumor-specific antigens recognized by cytolytic T lymphocytes (CTL) produces significant tumor regressions in a minority…”
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Tumoral and Immunologic Response After Vaccination of Melanoma Patients With an ALVAC Virus Encoding MAGE Antigens Recognized by T Cells by VAN BAREN, Nicolas, BONNET, Marie-Claude, ESCUDIER, Bernard, NEGRIER, Sylvie, DIETRICH, Pierre-Yves, MARANINCHI, Dominique, OSANTO, Susanne, MEYER, Ralf G, RITTER, Gerd, MOINGEON, Philippe, TARTAGLIA, Jim, VAN DER BRUGGEN, Pierre, DRENO, Brigitte, COULIE, Pierre G, BOON, Thierry, KHAMMARI, Amir, DORVAL, Thierry, PIPERNO-NEUMANN, Sophie, LIENARD, Danielle, SPEISER, Daniel, MARCHAND, Marie, BRICHARD, Vincent G

“…To evaluate the toxicity, antitumoral effectiveness, and immunogenicity of repeated vaccinations with ALVAC miniMAGE-1/3, a recombinant canarypox virus…”
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Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy by Bourdeaux, Christophe, Lurquin, Christophe, Jacquemart, Isabelle, Lethé, Bernard, Brasseur, Francis, van Baren, Nicolas, Baurain, Jean-François, Dyson, Julian, Van Snick, Jacques, Uyttenhove, Catherine, Boon, Thierry

“…Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We…”
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Five new human cancer‐germline genes identified among 12 genes expressed in spermatogonia by Loriot, Axelle, Boon, Thierry, De Smet, Charles

“…An important class of tumor‐specific antigens is encoded by male germline‐specific genes, such as MAGE genes, that are activated in many cancers of various…”
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Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, MAGE-A4 and SAGE by MIYAHARA, Yoshihiro, NAOTA, Hiroaki, MAJIMA, Yuichi, LEMONNIER, Francois A, BOON, Thierry, SHIKU, Hiroshi, CLARK, Carolyn E, VONDERHEIDE, Robert H, LIJIE WANG, HIASA, Atsunori, GOTO, Megumi, WATANABE, Masato, KITANO, Shigehisa, OKUMURA, Satoshi, TAKEMITSU, Testsushi, YUTA, Atsushi

“…Purpose : For identification of CTL epitopes useful for cancer vaccines, it is crucial to determine whether cognate epitopes are presented on the cell surface…”
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High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene by Baurain, Jean-Francois, Colau, Didier, van Baren, Nicolas, Landry, Claire, Martelange, Valerie, Vikkula, Miikka, Boon, Thierry, Coulie, Pierre G

“…We have identified an Ag recognized by autologous CTL on the melanoma cells of a patient who enjoyed an unusually favorable clinical evolution. The antigenic…”
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Structure, chromosomal localization, and expression of 12 genes of the MAGE family by De Plaen, E, Arden, K, Traversari, C, Gaforio, J J, Szikora, J P, De Smet, C, Brasseur, F, van der Bruggen, P, Lethé, B, Lurquin, C

“…We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing…”
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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy by Coulie, Pierre G., Van den Eynde, Benoît J., van der Bruggen, Pierre, Boon, Thierry

“…In this Timeline, the authors discuss the identification of tumour antigens that are recognized by T lymphocytes and how these findings can be effectively and…”
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Human T cell responses against melanoma by Boon, Thierry, Coulie, Pierre G, Van den Eynde, Benoît J, van der Bruggen, Pierre

“…Many antigens recognized by autologous T lymphocytes have been identified on human melanoma. Melanoma patients usually mount a spontaneous T cell response…”
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Mouse tumor rejection antigens P815A and P815B: two epitopes carried by a single peptide by Lethé, B, van den Eynde, B, van Pel, A, Corradin, G, Boon, T

“…Mouse mastocytoma P815 expresses several distinct tumor rejection antigens recognized by syngeneic cytolytic T lymphocytes (CTL). Two of these tumor rejection…”
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Identification of a Second Major Tumor-Specific Antigen Recognized by CTLs on Mouse Mastocytoma P815 by Bilsborough, Janine, Van Pel, Aline, Uyttenhove, Catherine, Boon, Thierry, Van den Eynde, Benoit J

“…Murine mastocytoma P815 induces CTL responses against at least four distinct Ags (AB, C, D, and E). Recent studies have shown that the main component of the…”
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