Search Results - "Boon, Louis"

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion by Hatzioannou, Aikaterini, Banos, Aggelos, Sakelaropoulos, Theodore, Fedonidis, Constantinos, Vidali, Maria-Sophia, Köhne, Maren, Händler, Kristian, Boon, Louis, Henriques, Ana, Koliaraki, Vasiliki, Georgiadis, Panagiotis, Zoidakis, Jerome, Termentzi, Aikaterini, Beyer, Marc, Chavakis, Triantafyllos, Boumpas, Dimitrios, Tsirigos, Aristotelis, Verginis, Panayotis

“…Regulatory T (T reg ) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of T reg cells shows limited…”
Get full text

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity by Laoui, Damya, Keirsse, Jiri, Morias, Yannick, Van Overmeire, Eva, Geeraerts, Xenia, Elkrim, Yvon, Kiss, Mate, Bolli, Evangelia, Lahmar, Qods, Sichien, Dorine, Serneels, Jens, Scott, Charlotte L., Boon, Louis, De Baetselier, Patrick, Mazzone, Massimiliano, Guilliams, Martin, Van Ginderachter, Jo A.

“…Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including…”
Get full text

Newcastle disease virotherapy induces long‐term survival and tumor‐specific immune memory in orthotopic glioma through the induction of immunogenic cell death by Koks, Carolien A., Garg, Abhishek D., Ehrhardt, Michael, Riva, Matteo, Vandenberk, Lien, Boon, Louis, Vleeschouwer, Steven De, Agostinis, Patrizia, Graf, Norbert, Van Gool, Stefaan W.

“…The oncolytic features of several naturally oncolytic viruses have been shown on Glioblastoma Multiforme cell lines and in xenotransplant models. However,…”
Get full text

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis by van der Fits, Leslie, Mourits, Sabine, Voerman, Jane S. A, Kant, Marius, Boon, Louis, Laman, Jon D, Cornelissen, Ferry, Mus, Anne-Marie, Florencia, Edwin, Prens, Errol P, Lubberts, Erik

“…Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder…”
Get full text

Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage by Aparicio-Domingo, Patricia, Romera-Hernandez, Monica, Karrich, Julien J, Cornelissen, Ferry, Papazian, Natalie, Lindenbergh-Kortleve, Dicky J, Butler, James A, Boon, Louis, Coles, Mark C, Samsom, Janneke N, Cupedo, Tom

“…Disruption of the intestinal epithelial barrier allows bacterial translocation and predisposes to destructive inflammation. To ensure proper barrier…”
Get full text

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression by Papafragkos, Iosif, Grigoriou, Maria, Boon, Louis, Kloetgen, Andreas, Hatzioannou, Aikaterini, Verginis, Panayotis

“…Myeloid-derived suppressor cells (MDSCs) are myeloid precursors that exert potent immunosuppressive properties in cancer. Despite the extensive knowledge on…”
Get full text

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy by Van Woensel, Matthias, Mathivet, Thomas, Wauthoz, Nathalie, Rosière, Rémi, Garg, Abhishek D., Agostinis, Patrizia, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence, Boon, Louis, Belmans, Jochen, Van Gool, Stefaan W., Gerhardt, Holger, Amighi, Karim, De Vleeschouwer, Steven

“…In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via…”
Get full text

PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity by Oldenhove, Guillaume, Boucquey, Elodie, Taquin, Anaelle, Acolty, Valérie, Bonetti, Lynn, Ryffel, Bernhard, Le Bert, Marc, Englebert, Kevin, Boon, Louis, Moser, Muriel

“…Recent observations clearly highlight the critical role of type 2 innate lymphoid cells in maintaining the homeostasis of adipose tissues in humans and mice…”
Get full text

Dual blockage of both PD-L1 and CD47 enhances the therapeutic effect of oxaliplatin and FOLFOX in CT-26 mice tumor model by Alimohammadi, Reza, Mahmoodi Chalbatani, Ghanbar, Alimohammadi, Masoumeh, Ghaffari-Nazari, Haniyeh, Rahimi, Arezou, Mortaz, Esmail, Mossafa, Nariman, Boon, Louis, Jalali, Seyed Amir

“…Colorectal cancer is a poorly immunogenic. Such property can be reverted by using ICD. However, ICD inducers can also induce the expression of inhibitory…”
Get full text

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology by Aychek, Tegest, Mildner, Alexander, Yona, Simon, Kim, Ki-Wook, Lampl, Nardy, Reich-Zeliger, Shlomit, Boon, Louis, Yogev, Nir, Waisman, Ari, Cua, Daniel J., Jung, Steffen

“…Gut homeostasis and mucosal immune defense rely on the differential contributions of dendritic cells (DC) and macrophages. Here we show that colonic CX 3 CR1 +…”
Get full text

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice by Zemek, Rachael M., Chin, Wee Loong, Fear, Vanessa S., Wylie, Ben, Casey, Thomas H., Forbes, Cath, Tilsed, Caitlin M., Boon, Louis, Guo, Belinda B., Bosco, Anthony, Forrest, Alistair R. R., Millward, Michael J., Nowak, Anna K., Lake, Richard A., Lassmann, Timo, Lesterhuis, W. Joost

“…The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic…”
Get full text

Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis by Vandenhaute, Jessica, Avau, Anneleen, Filtjens, Jessica, Malengier-Devlies, Bert, Imbrechts, Maya, Van den Berghe, Nathalie, Ahmadzadeh, Kourosh, Mitera, Tania, Boon, Louis, Leclercq, Georges, Wouters, Carine, Matthys, Patrick

“…Mice deficient in IFN-γ (IFN-γ knockout [KO] mice) develop a systemic inflammatory syndrome in response to CFA, in contrast to CFA-challenged wild-type (WT)…”
Get full text

Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models by Chen, Chun-Yu, Wang, Pin-Yi, Hutzen, Brian, Sprague, Les, Swain, Hayley M., Love, Julia K., Stanek, Joseph R., Boon, Louis, Conner, Joe, Cripe, Timothy P.

“…Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of…”
Get full text

Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin by Dudek-Perić, Aleksandra M, Ferreira, Gabriela B, Muchowicz, Angelika, Wouters, Jasper, Prada, Nicole, Martin, Shaun, Kiviluoto, Santeri, Winiarska, Magdalena, Boon, Louis, Mathieu, Chantal, van den Oord, Joost, Stas, Marguerite, Gougeon, Marie-Lise, Golab, Jakub, Garg, Abhishek D, Agostinis, Patrizia

“…Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger…”
Get full text

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1 by Vijver, Saskia V, Singh, Akashdip, Mommers-Elshof, Eline T A M, Meeldijk, Jan, Copeland, Ronald, Boon, Louis, Langermann, Sol, Flies, Dallas, Meyaard, Linde, Ramos, M Inês Pascoal

“…The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor…”
Get full text

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development by Varveri, Athina, Papadopoulou, Miranta, Papadovasilakis, Zacharias, Compeer, Ewoud B., Legaki, Aigli-Ioanna, Delis, Anastasios, Damaskou, Vasileia, Boon, Louis, Papadogiorgaki, Sevasti, Samiotaki, Martina, Foukas, Periklis G., Eliopoulos, Aristides G., Hatzioannou, Aikaterini, Alissafi, Themis, Dustin, Michael L., Verginis, Panayotis

“…Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in…”
Get full text

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection by Filbey, Kara J, Grainger, John R, Smith, Katherine A, Boon, Louis, Rooijen, Nico, Harcus, Yvonne, Jenkins, Stephen, Hewitson, James P, Maizels, Rick M

“…The nematode Heligmosomoides polygyrus is an excellent model for intestinal helminth parasitism. Infection in mice persists for varying lengths of time in…”
Get full text

Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg, Abhishek D., Vandenberk, Lien, Van Woensel, Matthias, Belmans, Jochen, Schaaf, Marco, Boon, Louis, De Vleeschouwer, Steven, Agostinis, Patrizia

“…Glioblastoma (GBM) is resistant to most multimodal therapies. Clinical success of immune-checkpoint inhibitors (ICIs) has spurred interest in applying ICIs…”
Get full text

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway by Volpi, Claudia, Fallarino, Francesca, Pallotta, Maria T., Bianchi, Roberta, Vacca, Carmine, Belladonna, Maria L., Orabona, Ciriana, De Luca, Antonella, Boon, Louis, Romani, Luigina, Grohmann, Ursula, Puccetti, Paolo

“…CpG-rich oligodeoxynucleotides activate the immune system, leading to innate and acquired immune responses. The immune-stimulatory effects of CpG-rich…”
Get full text

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis by Lievens, Dirk, Zernecke, Alma, Seijkens, Tom, Soehnlein, Oliver, Beckers, Linda, Munnix, Imke C.A., Wijnands, Erwin, Goossens, Pieter, van Kruchten, Roger, Thevissen, Larissa, Boon, Louis, Flavell, Richard A., Noelle, Randolph J., Gerdes, Norbert, Biessen, Erik A., Daemen, Mat J.A.P., Heemskerk, Johan W.M., Weber, Christian, Lutgens, Esther

“…CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic…”
Get full text