Search Results - "Boon, C. C."

Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease by Gounder, Anshu P, Boon, Adrianus C M

“…Influenza viruses continue to be a major global health threat. Severity and clinical outcome of influenza disease is determined by both viral and host factors…”
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Triple negative breast cancer in Asia: An insider’s view by Wang, Chao, Kar, Shreya, Lai, Xianning, Cai, Wanpei, Arfuso, Frank, Sethi, Gautam, Lobie, Peter E., Goh, Boon C., Lim, Lina H.K., Hartman, Mikael, Chan, Ching W., Lee, Soo C., Tan, Sing H., Kumar, Alan P.

“…•A comprehensive introduction on the characteristics of TNBC and its heterogeneity.•A comprehensive comparison of TNBC prevalence in Western and Asian…”
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Correlations between the Michigan Retinal Degeneration Questionnaire and visual function parameters in patients with retinitis pigmentosa by Karuntu, J. S., Nguyen, X. T., Boon, C. J. F.

“…Purpose To validate the use of best‐corrected visual acuity (BCVA), low‐luminance visual acuity (LLVA), low‐luminance deficit (LLD; the difference between BCVA…”
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The microbial metabolite desaminotyrosine protects from influenza through type I interferon by Steed, Ashley L., Christophi, George P., Kaiko, Gerard E., Sun, Lulu, Goodwin, Victoria M., Jain, Umang, Esaulova, Ekaterina, Artyomov, Maxim N., Morales, David J., Holtzman, Michael J., Boon, Adrianus C. M., Lenschow, Deborah J., Stappenbeck, Thaddeus S.

“…The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the…”
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Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways by Heng, Boon C, Zhang, Xuehui, Aubel, Dominique, Bai, Yunyang, Li, Xiaochan, Wei, Yan, Fussenegger, Martin, Deng, Xuliang

“…The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological…”
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Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease by Brinks, J., van Dijk, E.H.C., Klaassen, I., Schlingemann, R.O., Kielbasa, S.M., Emri, E., Quax, P.H.A., Bergen, A.A., Meijer, O.C., Boon, C.J.F.

“…The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood…”
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Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters by Boon, Adrianus C M, Darling, Tamarand L, Halfmann, Peter J, Franks, John, Webby, Richard J, Barouch, Dan H, Port, Julia R, Munster, Vincent J, Diamond, Michael S, Kawaoka, Yoshihiro

“…JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of…”
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Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19 by Li, Fuhai, Boon, Adrianus C. M., Michelson, Andrew P., Foraker, Randi E., Zhan, Ming, Payne, Philip R. O.

“…Although vaccines have been evaluated and approved for SARS-CoV-2 infection prevention, there remains a lack of effective treatments to reduce the mortality of…”
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COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis by Soung, Allison L, Vanderheiden, Abigail, Nordvig, Anna S, Sissoko, Cheick A, Canoll, Peter, Mariani, Madeline B, Jiang, Xiaoping, Bricker, Traci, Rosoklija, Gorazd B, Arango, Victoria, Underwood, Mark, Mann, J John, Dwork, Andrew J, Goldman, James E, Boon, Adrianus C M, Boldrini, Maura, Klein, Robyn S

“…Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with acute and postacute cognitive and neuropsychiatric symptoms…”
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Study of reinforcement support mechanisms for wide-span horse-shoe-shaped openings in horizontally layered jointed rock using the distinct element method by Boon, C. W.

“…Wide-span openings in horizontally layered jointed rock were analysed using the distinct element method (DEM) to provide additional insight into rock bolt…”
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The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold by Zhang, Wei, Chen, Jialin, Tao, Jiadong, Hu, Changchang, Chen, Longkun, Zhao, Hongshi, Xu, Guowei, Heng, Boon C, Ouyang, Hong Wei

“…Abstract The repair of osteochondral defects can be enhanced with scaffolds but is often accompanied with undesirable terminal differentiation of bone…”
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Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans by Sandbulte, Matthew R, Jimenez, Gretchen S, Boon, Adrianus C M, Smith, Larry R, Treanor, John J, Webby, Richard J

“…A pandemic H5N1 influenza outbreak would be facilitated by an absence of immunity to the avian-derived virus in the human population. Although this condition…”
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Expert perspectives on the introduction of Triple Artemisinin-based Combination Therapies (TACTs) in Southeast Asia: a Delphi study by de Haan, Freek, Boon, Wouter P C, Amaratunga, Chanaki, Dondorp, Arjen M

“…Triple Artemisinin-based Combination Therapies (TACTs) are being developed as a response to artemisinin and partner drug resistance in Southeast Asia. However,…”
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An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo by Tsuji, Moriya, Nair, Manoj S., Masuda, Kazuya, Castagna, Candace, Chong, Zhenlu, Darling, Tamarand L., Seehra, Kuljeet, Hwang, Youngmin, Ribeiro, Ágata Lopes, Ferreira, Geovane Marques, Corredor, Laura, Coelho-dos-Reis, Jordana Grazziela Alves, Tsuji, Yukiko, Mori, Munemasa, Boon, Adrianus C. M., Diamond, Michael S., Huang, Yaoxing, Ho, David D.

“…Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the…”
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Epigenetic Therapy Using Belinostat for Patients With Unresectable Hepatocellular Carcinoma: A Multicenter Phase I/II Study With Biomarker and Pharmacokinetic Analysis of Tumors From Patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group by YEO, Winnie, CHUNG, Hyun C, HUI, Edwin P, JEUNG, Hei C, ROH, Jae K, YU, Simon C. H, TO, Ka F, QIAN TAO, MA, Brigette B, CHAN, Anthony W. H, TONG, Joanna H. M, ERLICHMAN, Charles, CHAN, Stephen L, CHAN, Anthony T. C, GOH, Boon C, WANG, Ling Z, LIM, Robert, PICUS, Joel, BOYER, Michael, MO, Frankie K. F, KOH, Jane, RHA, Sun Y

“…Epigenetic aberrations have been reported in hepatocellular carcinoma (HCC). In this study of patients with unresectable HCC and chronic liver disease,…”
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Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication by Williams, Graham D., Townsend, Dana, Wylie, Kristine M., Kim, Preston J., Amarasinghe, Gaya K., Kutluay, Sebla B., Boon, Adrianus C. M.

“…Influenza A virus nucleoprotein (NP) association with viral RNA (vRNA) is essential for packaging, but the pattern of NP binding to vRNA is unclear. Here we…”
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North-South Divide: Chemo-Immunotherapy Combination in Head and Neck Squamous Cell Cancer (HNSCC) by Boon, I.S., Boon, C.S., Oguejiofor, K., Ramkumar, S.

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Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection by Nair, Sharmila, Huynh, Jeremy P, Lampropoulou, Vicky, Loginicheva, Ekaterina, Esaulova, Ekaterina, Gounder, Anshu P, Boon, Adrianus C M, Schwarzkopf, Elizabeth A, Bradstreet, Tara R, Edelson, Brian T, Artyomov, Maxim N, Stallings, Christina L, Diamond, Michael S

“…Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell…”
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Pharyngeal Constrictor Muscle Sparing in Head and Neck Radiotherapy by Oguejiofor, K., Boon, C.S., Ramkumar, S., Boon, I.S.

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When health care workers perceive high-commitment HRM will they be motivated to continue working in health care? It may depend on their supervisor and intrinsic motivation by Schopman, L. M., Kalshoven, K., Boon, C.

“…In this health care field study, we examined the link between human resource management (HRM), transformational leadership, intrinsic motivation and motivation…”
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