The behavioral variant of Alzheimer's disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

The behavioral variant of Alzheimer's disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer's disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal de...

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Bibliographic Details
Published in:Alzheimer's research & therapy Vol. 14; no. 1; p. 11
Main Authors: Singleton, E H, Pijnenburg, Y A L, Gami-Patel, P, Boon, B D C, Bouwman, F, Papma, J M, Seelaar, H, Scheltens, P, Grinberg, L T, Spina, S, Nana, A L, Rabinovici, G D, Seeley, W W, Ossenkoppele, R, Dijkstra, A A
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 20-01-2022
BioMed Central
BMC
Subjects:
Age
Alzheimer Disease - pathology
Alzheimer's disease
Anterior cingulate cortex
Apathy
Behavior
Clinical Medicine
Dementia
Frontotemporal dementia
Frontotemporal Dementia - pathology
Frontotemporal Lobar Degeneration - pathology
Genetic aspects
Gyrus Cinguli - pathology
Health aspects
Humans
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Neurologi
Neurological research
Neurology
Neurons
Neurons - pathology
Pathology
Patients
Phylogeny
Schizophrenia
Von Economo Neurons
Netherlands
Pathology
Von Economo Neurons
Behavior
Alzheimer’s disease
Frontotemporal dementia
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Summary:The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer's disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neuronal populations show a selective loss in bvAD. VENs and GABA receptor subunit theta (GABRQ)-immunoreactive pyramidal neurons of the anterior cingulate cortex (ACC) were quantified in post-mortem tissue of patients with bvAD (n = 9) and compared to typical AD (tAD, n = 6), bvFTD due to frontotemporal lobar degeneration based on TDP-43 pathology (FTLD, n = 18) and controls (n = 13) using ANCOVAs adjusted for age and Bonferroni corrected. In addition, ratios of VENs and GABRQ-immunoreactive (GABRQ-ir) pyramidal neurons over all Layer 5 neurons were compared between groups to correct for overall Layer 5 neuronal loss. The number of VENs or GABRQ-ir neurons did not differ significantly between bvAD (VENs: 26.0 ± 15.3, GABRQ-ir pyramidal: 260.4 ± 87.1) and tAD (VENs: 32.0 ± 18.1, p = 1.00, GABRQ-ir pyramidal: 349.8 ± 109.6, p = 0.38) and controls (VENs: 33.5 ± 20.3, p = 1.00, GABRQ-ir pyramidal: 339.4 ± 95.9, p = 0.37). Compared to bvFTD, patients with bvAD showed significantly more GABRQ-ir pyramidal neurons (bvFTD: 140.5 ± 82.658, p = 0.01) and no significant differences in number of VENs (bvFTD: 10.9 ± 13.8, p = 0.13). Results were similar when assessing the number of VENs and GABRQ-ir relative to all neurons of Layer 5. VENs and phylogenetically related neurons did not show a selective loss in the ACC in patients with bvAD. Our results suggest that, unlike in bvFTD, the clinical presentation in bvAD may not be related to the loss of VENs and related neurons in the ACC.
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ISSN:1758-9193
1758-9193
DOI:10.1186/s13195-021-00947-9