Search Results - "Boon, Adrianus C.M"

Evidence of Human Bourbon Virus Infections, North Carolina, USA by Zychowski, Diana L, Bamunuarachchi, Gayan, Commins, Scott P, Boyce, Ross M, Boon, Adrianus C M

“…Bourbon virus is a tickborne virus that can cause human disease. Cases have been reported in Kansas, Oklahoma, and Missouri, USA. We identified Bourbon…”
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Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis by Lu, Qun, Yokoyama, Christine C., Williams, Jesse W., Baldridge, Megan T., Jin, Xiaohua, DesRochers, Brittany, Bricker, Traci, Wilen, Craig B., Bagaitkar, Juhi, Loginicheva, Ekaterina, Sergushichev, Alexey, Kreamalmeyer, Darren, Keller, Brian C., Zhao, Yan, Kambal, Amal, Green, Douglas R., Martinez, Jennifer, Dinauer, Mary C., Holtzman, Michael J., Crouch, Erika C., Beatty, Wandy, Boon, Adrianus C.M., Zhang, Hong, Randolph, Gwendalyn J., Artyomov, Maxim N., Virgin, Herbert W.

“…Mutations in the autophagy gene EPG5 are linked to the multisystem human disease Vici syndrome, which is characterized in part by pulmonary abnormalities,…”
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Role of terrestrial wild birds in ecology of influenza A virus (H5N1) by Boon, Adrianus C M, Sandbulte, Matthew R, Seiler, Patrick, Webby, Richard J, Songserm, Thaweesak, Guan, Yi, Webster, Robert G

“…House sparrows, European starlings, and Carneux pigeons were inoculated with 4 influenza A (H5N1) viruses isolated from different avian species. We monitored…”
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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection by Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.

“…SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials,…”
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Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans by Sandbulte, Matthew R, Jimenez, Gretchen S, Boon, Adrianus C M, Smith, Larry R, Treanor, John J, Webby, Richard J

“…A pandemic H5N1 influenza outbreak would be facilitated by an absence of immunity to the avian-derived virus in the human population. Although this condition…”
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Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA by Aziati, Ishmael D., Jnr, Derek McFarland, Antia, Avan, Joshi, Astha, Aviles-Gamboa, Anahi, Lee, Preston, Harastani, Houda, Wang, David, Adalsteinsson, Solny A., Boon, Adrianus C.M.

“…Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess…”
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6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro by Swaim, Caleb D., Dwivedi, Varun, Perng, Yi-Chieh, Zhao, Xu, Canadeo, Larissa A., Harastani, Houda H., Darling, Tamarand L., Boon, Adrianus C.M., Lenschow, Deborah J., Kulkarni, Viraj, Huibregtse, Jon M.

“…The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of…”
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Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice by DesRochers, Brittany L, Chen, Rita E, Gounder, Anshu P, Pinto, Amelia K, Bricker, Traci, Linton, Camille N, Rogers, Corianne D, Williams, Graham D, Webby, Richard J, Boon, Adrianus C.M

“…Abstract Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are…”
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Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread by Yen, Hui-Ling, Aldridge, Jerry R, Boon, Adrianus C.M, Ilyushina, Natalia A, Salomon, Rachelle, Hulse-Post, Diane J, Marjuki, Henju, Franks, John, Boltz, David A, Bush, Dorothy, Lipatov, Aleksandr S, Webby, Richard J, Rehg, Jerold E, Webster, Robert G

“…The HA of influenza virus is a receptor-binding and fusion protein that is required to initiate infection. The HA receptor-binding domain determines the…”
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mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2 by Darling, Tamarand L, Ying, Baoling, Whitener, Bradley, VanBlargan, Laura A, Bricker, Traci L, Liang, Chieh-Yu, Joshi, Astha, Bamunuarachchi, Gayan, Seehra, Kuljeet, Schmitz, Aaron J, Halfmann, Peter J, Kawaoka, Yoshihiro, Elbashir, Sayda M, Edwards, Darin K, Thackray, Larissa B, Diamond, Michael S, Boon, Adrianus C M

“…Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, viral variants with greater transmissibility or immune-evasion…”
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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses by Hong, Jun P., Reynoso, Glennys V., Andhey, Prabhakar S., Swain, Amanda, Turner, Jackson S., Boon, Adrianus C.M., Krammer, Florian, Ellebedy, Ali H., Zanini, Fabio, Artyomov, Maxim, Hickman, Heather D., Diamond, Michael S.

“…CD137 is a costimulatory receptor expressed on natural killer cells, T cells, and subsets of dendritic cells. An agonistic monoclonal antibody (mAb) against…”
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Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses by Sandbulte, Matthew R, Boon, Adrianus C.M, Webby, Richard J, Riberdy, Janice M

“…Abstract Mechanisms underlying the virulence of H5N1 influenza viruses in humans are poorly understood, though evidence of hyperinflammation and systemic viral…”
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Influenza Pathogenesis: The role of host factors on severity of disease by Gounder, Anshu P., Boon, Adrianus C.M.

“…Influenza viruses continue to be a major global health threat. Severity and clinical outcome of influenza disease is determined by both viral and host factors…”
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Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease by Gounder, Anshu P, Boon, Adrianus C M

“…Influenza viruses continue to be a major global health threat. Severity and clinical outcome of influenza disease is determined by both viral and host factors…”
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Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies by Chen, Rita E., Zhang, Xianwen, Case, James Brett, Winkler, Emma S., Liu, Yang, VanBlargan, Laura A., Liu, Jianying, Errico, John M., Xie, Xuping, Suryadevara, Naveenchandra, Gilchuk, Pavlo, Zost, Seth J., Tahan, Stephen, Droit, Lindsay, Turner, Jackson S., Kim, Wooseob, Schmitz, Aaron J., Thapa, Mahima, Wang, David, Boon, Adrianus C. M., Presti, Rachel M., O’Halloran, Jane A., Kim, Alfred H. J., Deepak, Parakkal, Pinto, Dora, Fremont, Daved H., Crowe, James E., Corti, Davide, Virgin, Herbert W., Ellebedy, Ali H., Shi, Pei-Yong, Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize…”
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The microbial metabolite desaminotyrosine protects from influenza through type I interferon by Steed, Ashley L., Christophi, George P., Kaiko, Gerard E., Sun, Lulu, Goodwin, Victoria M., Jain, Umang, Esaulova, Ekaterina, Artyomov, Maxim N., Morales, David J., Holtzman, Michael J., Boon, Adrianus C. M., Lenschow, Deborah J., Stappenbeck, Thaddeus S.

“…The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the…”
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Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens by Karvas, Rowan M., Khan, Shafqat A., Verma, Sonam, Yin, Yan, Kulkarni, Devesha, Dong, Chen, Park, Kyoung-mi, Chew, Brian, Sane, Eshan, Fischer, Laura A., Kumar, Deepak, Ma, Liang, Boon, Adrianus C.M., Dietmann, Sabine, Mysorekar, Indira U., Theunissen, Thorold W.

“…Trophoblast organoids derived from placental villi provide a 3D model system of human placental development, but access to first-trimester tissues is limited…”
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Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection by Nair, Sharmila, Huynh, Jeremy P, Lampropoulou, Vicky, Loginicheva, Ekaterina, Esaulova, Ekaterina, Gounder, Anshu P, Boon, Adrianus C M, Schwarzkopf, Elizabeth A, Bradstreet, Tara R, Edelson, Brian T, Artyomov, Maxim N, Stallings, Christina L, Diamond, Michael S

“…Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell…”
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RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging by Shafiuddin, Md, Boon, Adrianus C.M.

“…The influenza A virus (IAV), a respiratory pathogen for humans, poses serious medical and economic challenges to global healthcare systems. The IAV genome,…”
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In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains by Chen, Rita E., Winkler, Emma S., Case, James Brett, Aziati, Ishmael D., Bricker, Traci L., Joshi, Astha, Darling, Tamarand L., Ying, Baoling, Errico, John M., Shrihari, Swathi, VanBlargan, Laura A., Xie, Xuping, Gilchuk, Pavlo, Zost, Seth J., Droit, Lindsay, Liu, Zhuoming, Stumpf, Spencer, Wang, David, Handley, Scott A., Stine, W. Blaine, Shi, Pei-Yong, Davis-Gardner, Meredith E., Suthar, Mehul S., Knight, Miguel Garcia, Andino, Raul, Chiu, Charles Y., Ellebedy, Ali H., Fremont, Daved H., Whelan, Sean P. J., Crowe, James E., Purcell, Lisa, Corti, Davide, Boon, Adrianus C. M., Diamond, Michael S.

“…Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures. Although cell culture experiments have demonstrated a loss of potency of…”
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