Search Results - "Booms, Alix"

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk by Booms, Alix, Coetzee, Gerhard A.

“…Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD,…”
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Parkinson's disease genetic risk in a midbrain neuronal cell line by Pierce, Steven E., Tyson, Trevor, Booms, Alix, Prahl, Jordan, Coetzee, Gerhard A.

“…In genome-wide association studies of complex diseases, many risk polymorphisms are found to lie in non-coding DNA and likely confer risk through…”
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α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease by Cole, Tracy A, Zhao, Hien, Collier, Timothy J, Sandoval, Ivette, Sortwell, Caryl E, Steece-Collier, Kathy, Daley, Brian F, Booms, Alix, Lipton, Jack, Welch, Mackenzie, Berman, Melissa, Jandreski, Luke, Graham, Danielle, Weihofen, Andreas, Celano, Stephanie, Schulz, Emily, Cole-Strauss, Allyson, Luna, Esteban, Quach, Duc, Mohan, Apoorva, Bennett, C Frank, Swayze, Eric E, Kordasiewicz, Holly B, Luk, Kelvin C, Paumier, Katrina L

“…Parkinson's disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single…”
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Post-GWAS knowledge gap: the how, where, and when by Pierce, Steven E., Booms, Alix, Prahl, Jordan, van der Schans, Edwin J. C., Tyson, Trevor, Coetzee, Gerhard A.

“…Genetic risk for complex diseases very rarely reflects only Mendelian-inherited phenotypes where single-gene mutations can be followed in families by linkage…”
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Parkinson’s disease risk enhancers in microglia by Booms, Alix, Pierce, Steven E., van der Schans, Edwin J.C., Coetzee, Gerhard A.

“…Genome-wide association studies have identified thousands of single nucleotide polymorphisms that associate with increased risk for Parkinson’s disease (PD),…”
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MCF-7 as a Model for Functional Analysis of Breast Cancer Risk Variants by Booms, Alix, Coetzee, Gerhard A, Pierce, Steven E

“…Breast cancer genetic predisposition is governed by more than 142 loci as revealed by genome-wide association studies (GWAS). The functional contribution of…”
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Functional Evaluation of a Parkinson’s Disease Risk Enhancer in Microglia by Booms, Alix N

“…Genome-wide association studies (GWAS) have uncovered thousands of low penetrant single nucleotide polymorphisms (SNPs) that associate with increased risk for…”
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