Search Results - "Boom, W Henry"

The knowns and unknowns of latent Mycobacterium tuberculosis infection by Boom, W Henry, Schaible, Ulrich E, Achkar, Jacqueline M

“…Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years. While tuberculosis (TB), one of the deadliest infectious diseases, is…”
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Regulation of antigen presentation by Mycobacterium tuberculosis : a role for Toll-like receptors by Harding, Clifford V, Boom, W. Henry

“…Key Points Mycobacterium tuberculosis survives in the host in antigen-presenting cells (APCs) such as macrophages and dendritic cells. APCs present antigens in…”
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Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection by Simmons, Jason D., Stein, Catherine M., Seshadri, Chetan, Campo, Monica, Alter, Galit, Fortune, Sarah, Schurr, Erwin, Wallis, Robert S., Churchyard, Gavin, Mayanja-Kizza, Harriet, Boom, W. Henry, Hawn, Thomas R.

“…Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a long-lived latent infection in a substantial proportion of the human…”
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IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure by Lu, Lenette L., Smith, Malisa T., Yu, Krystle K. Q., Luedemann, Corinne, Suscovich, Todd J., Grace, Patricia S., Cain, Adam, Yu, Wen Han, McKitrick, Tanya R., Lauffenburger, Douglas, Cummings, Richard D., Mayanja-Kizza, Harriet, Hawn, Thomas R., Boom, W. Henry, Stein, Catherine M., Fortune, Sarah M., Seshadri, Chetan, Alter, Galit

“…Exposure to Mycobacterium tuberculosis ( Mtb ) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection…”
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Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection by Yoshimoto, Tetsuya, Kittaka, Mizuho, Doan, Andrew Anh Phuong, Urata, Rina, Prideaux, Matthew, Rojas, Roxana E., Harding, Clifford V., Henry Boom, W., Bonewald, Lynda F., Greenfield, Edward M., Ueki, Yasuyoshi

“…The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial…”
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Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis by Suliman, Sara, Thompson, Ethan G, Sutherland, Jayne, Weiner, 3rd, January, Ota, Martin O C, Shankar, Smitha, Penn-Nicholson, Adam, Thiel, Bonnie, Erasmus, Mzwandile, Maertzdorf, Jeroen, Duffy, Fergal J, Hill, Philip C, Hughes, E Jane, Stanley, Kim, Downing, Katrina, Fisher, Michelle L, Valvo, Joe, Parida, Shreemanta K, van der Spuy, Gian, Tromp, Gerard, Adetifa, Ifedayo M O, Donkor, Simon, Howe, Rawleigh, Mayanja-Kizza, Harriet, Boom, W Henry, Dockrell, Hazel M, Ottenhoff, Tom H M, Hatherill, Mark, Aderem, Alan, Hanekom, Willem A, Scriba, Thomas J, Kaufmann, Stefan H E, Zak, Daniel E, Walzl, Gerhard

“…Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with…”
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Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease by Scriba, Thomas J, Penn-Nicholson, Adam, Shankar, Smitha, Hraha, Tom, Thompson, Ethan G, Sterling, David, Nemes, Elisa, Darboe, Fatoumatta, Suliman, Sara, Amon, Lynn M, Mahomed, Hassan, Erasmus, Mzwandile, Whatney, Wendy, Johnson, John L, Boom, W Henry, Hatherill, Mark, Valvo, Joe, De Groote, Mary Ann, Ochsner, Urs A, Aderem, Alan, Hanekom, Willem A, Zak, Daniel E

“…Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary tuberculosis disease in humans remains limited…”
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Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution? by McHenry, Michael L, Bartlett, Jacquelaine, Igo, Jr, Robert P, Wampande, Eddie M, Benchek, Penelope, Mayanja-Kizza, Harriet, Fluegge, Kyle, Hall, Noemi B, Gagneux, Sebastien, Tishkoff, Sarah A, Wejse, Christian, Sirugo, Giorgio, Boom, W Henry, Joloba, Moses, Williams, Scott M, Stein, Catherine M

“…Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither…”
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Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells by Richardson, Edward T, Shukla, Supriya, Sweet, David R, Wearsch, Pamela A, Tsichlis, Philip N, Boom, W Henry, Harding, Clifford V

“…Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses…”
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Bacterial Factors That Predict Relapse after Tuberculosis Therapy by Colangeli, Roberto, Jedrey, Hannah, Kim, Soyeon, Connell, Roy, Ma, Shuyi, Chippada Venkata, Uma D, Chakravorty, Soumitesh, Gupta, Aditi, Sizemore, Erin E, Diem, Lois, Sherman, David R, Okwera, Alphonse, Dietze, Reynaldo, Boom, W. Henry, Johnson, John L, Mac Kenzie, William R, Alland, David

“…In pretreatment isolates of M. tuberculosis with decrements of the minimum inhibitory concentration of isoniazid or rifampin below the standard resistance…”
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Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda by Stein, Catherine M, Nsereko, Mary, Malone, LaShaunda L, Okware, Brenda, Kisingo, Hussein, Nalukwago, Sophie, Chervenak, Keith, Mayanja-Kizza, Harriet, Hawn, Thomas R, Boom, W Henry

“…Abstract Background Resistance to latent Mycobacterium tuberculosis (M.tb) infection, identified by persistently negative tuberculin skin tests (TST) and…”
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Mycobacterium tuberculosis Membrane Vesicles Inhibit T Cell Activation by Athman, Jaffre J, Sande, Obondo J, Groft, Sarah G, Reba, Scott M, Nagy, Nancy, Wearsch, Pamela A, Richardson, Edward T, Rojas, Roxana, Boom, W Henry, Shukla, Supriya, Harding, Clifford V

“…utilizes multiple mechanisms to evade host immune responses, and inhibition of effector CD4 T cell responses by may contribute to immune evasion. TCR signaling…”
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Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages by Groft, Sarah G, Nagy, Nancy, Boom, W Henry, Harding, Clifford V

“…This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendritic cells (DCs) versus…”
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Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion by Shukla, Supriya, Richardson, Edward T, Athman, Jaffre J, Shi, Libin, Wearsch, Pamela A, McDonald, David, Banaei, Niaz, Boom, W Henry, Jackson, Mary, Harding, Clifford V

“…Mycobacterium tuberculosis (Mtb) virulence is decreased by genetic deletion of the lipoprotein LprG, but the function of LprG remains unclear. We report that…”
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ERK Signaling Is Essential for Macrophage Development by Richardson, Edward T, Shukla, Supriya, Nagy, Nancy, Boom, W Henry, Beck, Rose C, Zhou, Lan, Landreth, Gary E, Harding, Clifford V

“…Macrophages depend on colony stimulating factor 1 (also known as M-CSF) for their growth and differentiation, but the requirements for intracellular signals…”
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Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation by McHenry, Michael L, Simmons, Jason, Hong, Hyejeong, Malone, LaShaunda L, Mayanja-Kizza, Harriet, Bush, William S, Boom, W Henry, Hawn, Thomas R, Williams, Scott M, Stein, Catherine M

“…Tuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a…”
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Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL by Sande, Obondo J, Karim, Ahmad F, Li, Qing, Ding, Xuedong, Harding, Clifford V, Rojas, Roxana E, Boom, W Henry

“…Mycobacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation by downregulating the phosphorylation of key proximal…”
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Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection by Seshadri, Chetan, Sedaghat, Nafiseh, Campo, Monica, Peterson, Glenna, Wells, Richard D, Olson, Gregory S, Sherman, David R, Stein, Catherine M, Mayanja-Kizza, Harriet, Shojaie, Ali, Boom, W Henry, Hawn, Thomas R

“…Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious…”
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Human alveolar macrophages display marked hypo-responsiveness to IFN-γ in both proteomic and gene expression analysis by Thiel, Bonnie A, Lundberg, Kathleen C, Schlatzer, Daniela, Jarvela, Jessica, Li, Qing, Shaw, Rachel, Reba, Scott M, Fletcher, Shane, Beckloff, Sara E, Chance, Mark R, Boom, W Henry, Silver, Richard F, Bebek, Gurkan

“…Alveolar macrophages (AM) perform a primary defense mechanism in the lung through phagocytosis of inhaled particles and microorganisms. AM are known to be…”
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HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa by Windels, Etthel M, Wampande, Eddie M, Joloba, Moses L, Boom, W Henry, Goig, Galo A, Cox, Helen, Hella, Jerry, Borrell, Sonia, Gagneux, Sebastien, Brites, Daniela, Stadler, Tanja

“…Persons living with HIV are known to be at increased risk of developing tuberculosis (TB) disease upon infection with Mycobacterium tuberculosis (Mtb)…”
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