Search Results - "Bookchin, R M"

Deoxygenation permeabilizes sickle cell anaemia red cells to magnesium and reverses its gradient in the dense cells by Ortiz, O E, Lew, V L, Bookchin, R M

“…1. Our findings of a low total magnesium content in the dense fraction (over 1.118 g ml-1) of sickle cell anaemia (SS) red cells seemed inconsistent with the…”
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Effects of deoxygenation on active and passive Ca2+ transport and cytoplasmic Ca2+ buffering in normal human red cells by Tiffert, T, Etzion, Z, Bookchin, R M, Lew, V L

“…1. The effects of deoxygenation on cytoplasmic Ca2+ buffering, saturated Ca2+ extrusion rate through the Ca2+ pump (Vmax), passive Ca2+ influx and…”
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Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells by ETZION, Z, TIFFERT, T, BOOKCHIN, R. M, LEW, V. L

“…Elevated [Ca2+]i in deoxygenated sickle cell anemia (SS) red cells (RBCs) could trigger a major dehydration pathway via the Ca(2+)-sensitive K+ channel. But…”
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Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia by BOOKCHIN, R. M, ORTIZ, O. E, LEW, V. L

“…To explore our hypothesis of a direct reticulocyte origin of irreversibly sickled cells (ISCs), we fractionated light, reticulocyte-rich, and discocyte-rich…”
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Pathophysiology of sickle cell anemia by Bookchin, R M, Lew, V L

“…The anemia results from the markedly shortened circulatory survival of SS cells, together with a limited erythropoietic response. Both independent properties…”
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Mechanism of Spontaneous Inside-out Vesiculation of Red Cell Membranes by Lew, Virgilio L., Hockaday, Austin, Freeman, Carol J., Bookchin, Robert M.

“…In certain conditions, human red cell membranes spontaneously form inside out vesicles within 20 min after hypotonic lysis. Study of the geometry of this…”
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A mathematical model of the volume, pH, and ion content regulation in reticulocytes : application to the pathophysiology of sickle cell dehydration by LEW, V. L, FREEMAN, C. J, ORTIZ, O. E, BOOKCHIN, R. M

“…We developed a mathematical model of the reticulocyte, seeking to explain how a cell with similar volume but much higher ionic traffic than the mature red cell…”
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K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemia red blood cells by Etzion, Z, Lew, V L, Bookchin, R M

“…Previous studies have suggested ion transport heterogeneity among sickle cell anemia (SS) reticulocytes that could influence their dehydration susceptibility…”
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Characterization of the phosphatidylserine-exposing subpopulation of sickle cells by de Jong, Kitty, Larkin, Sandra K., Styles, Lori A., Bookchin, Robert M., Kuypers, Frans A.

“…Phosphatidylserine (PS), exclusively present in the inner monolayer of the normal red blood cell (RBC) membrane, is exposed in subpopulations of sickle cells…”
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Distribution of chloride permeabilities in normal human red cells by Raftos, J E, Bookchin, R M, Lew, V L

“…1. The rate of dehydration of K+ permeabilized red cells is influenced by their Cl- permeability (PCl). In instances of pathological K+ permeabilization,…”
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Measurement of the distribution of anion exchange function in normal human red cells by Raftos, J E, Bookchin, R M, Lew, V L

“…1. The aim of the present work was to investigate cell-to-cell variation in anion exchange turnover in normal human red cells. Red cells permeabilized to…”
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Role of reticulocyte transport heterogeneity in the generation of mature sickle cells with different volumes by Lew, V L, Bookchin, R M

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The cytosol-membrane interface of normal and sickle erythrocytes. Effect of hemoglobin deoxygenation and sickling by Eisinger, J, Flores, J, Bookchin, R M

“…The effect of deoxygenation on the amount of hemoglobin (Hb) proximal to the membranes of intact, density-fractionated normal (AA) and sickle (SS) red cells…”
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HbC compound heterozygotes [HbC/Hb Riyadh and HbC/Hb N‐Baltimore] with opposing effects upon HbC crystallization by Hirsch, Rhoda Elison, Witkowska, H. Ewa, Shafer, Frank, Lin, Margaret J., Balazs, Tatiana C., Bookchin, Robert M., Nagel, Ronald L.

“…Compound heterozygotes of variant haemoglobins (Hbs) with HbC, with or without novel phenotypic changes, have provided insight into the molecular basis of the…”
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Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability by Lew, V L, Ortiz, O E, Bookchin, R M

“…To explore basic properties of the sickling-induced cation permeability pathway, the Ca2+ component (Psickle-Ca) was studied in density-fractionated sickle…”
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Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S by Nagel, R L, Bookchin, R M, Johnson, J, Labie, D, Wajcman, H, Isaac-Sodeye, W A, Honig, G R, Schilirò, G, Crookston, J H, Matsutomo, K

“…We have previously found that the inhibitory effect of hemoglobin F (Hb F) on the polymerization of Hb S proceeds via the formation of asymmetrical hybrid…”
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Calcium Transport and Ultrastructure of Red Cells in β-Thalassemia Intermedia by Bookchin, Robert M., Ortiz, Olga E., Shalev, Oded, Tsurel, Shmuel, Rachmilewitz, Eliezer A., Hockaday, Austin, Lew, Virgilio L.

“…Reported findings of elevated total calcium (Ca) contents in erythrocytes (RBCs) from patients with β-thalassemia intermedia (β-TI) prompted the question of…”
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Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles by Lew, Virgilio L, Hockaday, Austin, Sepulveda, Maria-Isabel, Somlyo, Andrew P, Somlyo, Avril V, Ortiz, Olga E, Bookchin, Robert M

“…Much recent interest in the mechanism of dehydration of the dense subpopulation of sickle-cell anaemia (SS) red cells, including the 'irreversibly sickled…”
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Osmotic effects of protein polymerization : analysis of volume changes in sickle cell anemia red cells following deoxy-hemoglobin S polymerization by LEW, V. L, BOOKCHIN, R. M

“…Polymerization-depolymerization of proteins within cells and subcellular organelles may have powerful osmotic effects. As a model to study these we analyzed…”
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β -Chain contact sites in the haemoglobin S polymer by Castro, O, Rosa, J, Johnson, J, Schiliro, G, Labie, D, Wajcman, H, Moo-Penn, W, Garel, M. C, Bookchin, R. M, Nagel, R. L

“…The amino acid residues involved in the areas of contact that stabilise the haemoglobin S polymer fibre seem to be the same ones that stabilise the basic unit…”
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