Search Results - "Boohaker, Rebecca J"

GLI1: A Therapeutic Target for Cancer by Avery, Justin T., Zhang, Ruowen, Boohaker, Rebecca J.

“…GLI1 is a transcriptional effector at the terminal end of the Hedgehog signaling (Hh) pathway and is tightly regulated during embryonic development and tissue…”
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Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response by Xiao, Mingming, Zhang, Siyue, Liu, Zhuang, Mo, Yaqi, Wang, Han, Zhao, Xu, Yang, Xue, Boohaker, Rebecca J., Chen, Yang, Han, Yamei, Liu, Hong, Xu, Bo

“…Both the DNA damage response (DDR) and the mitotic checkpoint are critical for the maintenance of genomic stability. Among proteins involved in these…”
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Chaperonin containing TCP-1 (CCT/TRiC) is a novel therapeutic and diagnostic target for neuroblastoma by Cox, Amanda, Nierenberg, Daniel, Camargo, Oscar, Lee, Eunkyung, Khaled, Amr S., Mazar, Joseph, Boohaker, Rebecca J., Westmoreland, Tamarah J., Khaled, Annette R.

“…Chaperonin containing TCP1 (CCT/TRiC) is a multi-subunit protein folding complex that enables the cancer phenotype to emerge from the mutational landscape that…”
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Discovery of a novel inhibitor of kinesin-like protein KIFC1 by Zhang, Wei, Zhai, Ling, Wang, Yimin, Boohaker, Rebecca J, Lu, Wenyan, Gupta, Vandana V, Padmalayam, Indira, Bostwick, Robert J, White, E Lucile, Ross, Larry J, Maddry, Joseph, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of…”
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Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response by Chen, Yang, Xiao, Mingming, Mo, Yaqi, Ma, Jinlu, Han, Yamei, Li, Qing, Zeng, Qinghua, Boohaker, Rebecca J, Fried, Joshua, Li, Yonghe, Wang, Han, Xu, Bo

“…Abstract Background The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, which play a crucial…”
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The versatile functions of ATM kinase by Boohaker, Rebecca J, Xu, Bo

“…Ataxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia-telangiectasia, plays an essential role in the…”
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GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer by Zhang, Ruowen, Ma, Jinlu, Avery, Justin T., Sambandam, Vijaya, Nguyen, Theresa H., Xu, Bo, Suto, Mark J., Boohaker, Rebecca J.

“…Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we…”
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The preclinical efficacy of the novel hypomethylating agent NTX-301 as a monotherapy and in combination with venetoclax in acute myeloid leukemia by Lim, Byungho, Yoo, Dabin, Chun, Younghwa, Go, Areum, Cho, Kyung-Jin, Choi, Daeun, Jung, Myoung Eun, Lee, Ha Young, Boohaker, Rebecca J., Lee, Jin Soo, Jung, DooYoung, Choi, Gildon

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Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment by Haga, Christopher L, Ehrhardt, Götz R.A, Boohaker, Rebecca J, Davis, Randall S, Cooper, Max D

“…The Fc receptor-like protein 5 (FCRL5) on B cells has both an immunoreceptor tyrosine-based activation motif (ITAM)-like sequence and two consensus…”
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A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response by Xiao, Mingming, Fried, Joshua S., Ma, Jinlu, Su, Yang, Boohaker, Rebecca J., Zeng, Qinghua, Mo, Yaqi, Meng, Fanbiao, Xiang, Rong, Xu, Bo

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Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction by Boohaker, Rebecca J., Sambandam, Vijaya, Segura, Isaac, Miller, James, Suto, Mark, Xu, Bo

“…We report here the rational design and validation of a peptide inhibitor to the PD-1/PD-L1 interaction as an attempt to develop a viable alternative to current…”
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KIFC1 is a novel potential therapeutic target for breast cancer by Li, Yonghe, Lu, Wenyan, Chen, Dongquan, Boohaker, Rebecca J, Zhai, Ling, Padmalayam, Indira, Wennerberg, Krister, Xu, Bo, Zhang, Wei

“…Kinesin-like protein KIFC1, a normally nonessential kinesin motor, plays a critical role in centrosome clustering in cancer cells and is essential for the…”
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KAT5 promotes invasion and metastasis through C-MYC stabilization in ATC by Wei, Xi, Cai, Shang, Boohaker, Rebecca J, Fried, Joshua, Li, Ying, Hu, Linfei, Pan, Yi, Cheng, Ruifen, Zhang, Sheng, Tian, Ye, Gao, Ming, Xu, Bo

“…Anaplastic thyroid cancer (ATC) is an aggressive cancer with poor clinical prognosis. However, mechanisms driving ATC aggressiveness is not well known…”
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Abstract 180: Identification and characterization of ATM substrates in mitosis by Boohaker, Rebecca J., Zeng, Qinghua, Xu, Bo

“…Abstract The Ataxia-Telangiectasia Mutated (ATM) Kinase, mutation of which is responsible for the autosomal recessive disorder Ataxia-Telangiectasia, is an…”
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A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas by Liu, Ning, Boohaker, Rebecca J, Jiang, Chunling, Boohaker, James R, Xu, Bo

“…MicroRNA, a class of small non-coding RNAs, play critical roles in the cellular response to DNA damage induced by ionizing irradiation (IR). Growing evidence…”
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DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage by Wakeman, Timothy P, Yang, Aimin, Dalal, Naresh S, Boohaker, Rebecca J, Zeng, Qinghua, Ding, Qiang, Xu, Bo

“…Hexavalent chromium (Cr[VI]) is associated with occupational lung cancer and poses a significant public health concern. When exposed to Cr[VI], cells rapidly…”
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Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening by Zhang, Wei, Zhai, Ling, Lu, Wenyan, Boohaker, Rebecca J., Padmalayam, Indira, Li, Yonghe

“…Mitotic kinesin Eg5 is an attractive anticancer drug target. Discovery of Eg5 inhibitors has been focused on targeting the ‘monastrol‐binding site’. However,…”
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ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity by Boohaker, Rebecca J, Cui, Xiaoli, Stackhouse, Murray, Xu, Bo

“…Abstract Purpose Activation of the DNA damage responsive protein kinase ATM is a critical step for cellular survival in response to ionizing irradiation (IR)…”
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Integrative Analyses Reveal the Anticancer Mechanisms and Sensitivity Markers of the Next-Generation Hypomethylating Agent NTX-301 by Lim, Byungho, Yoo, Dabin, Chun, Younghwa, Go, Areum, Kim, Ji Yeon, Lee, Ha Young, Boohaker, Rebecca J, Cho, Kyung-Jin, Ahn, Sunjoo, Lee, Jin Soo, Jung, DooYoung, Choi, Gildon

“…Epigenetic dysregulation characterized by aberrant DNA hypermethylation is a hallmark of cancer, and it can be targeted by hypomethylating agents (HMAs)…”
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BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells by Boohaker, Rebecca J, Zhang, Ge, Carlson, Adina Loosley, Nemec, Kathleen N, Khaled, Annette R

“…The dual functionality of the tumor suppressor BAX is implied by the nonapoptotic functions of other members of the BCL-2 family. To explore this,…”
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