Search Results - "Boog, Claire J.P."

Modulation of the CD4+ T cell response after acellular pertussis vaccination in the presence of TLR4 ligation by Brummelman, Jolanda, Helm, Kina, Hamstra, Hendrik-Jan, van der Ley, Peter, Boog, Claire J.P, Han, Wanda G.H, van Els, Cécile A.C.M

“…Highlights • The duration of protection by current acellular pertussis vaccines is disappointing. • TLR4 ligand improve acellular pertussis vaccine-induced T…”
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Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy by Fransen, Floris, Heckenberg, Sebastiaan G B, Hamstra, Hendrik Jan, Feller, Moniek, Boog, Claire J P, van Putten, Jos P M, van de Beek, Diederik, van der Ende, Arie, van der Ley, Peter

“…Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Lipopolysaccharide (LPS), a major component of the Gram-negative…”
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Aging and impaired immunity to influenza viruses: Implications for vaccine development by Liu, Wai Ming, van der Zeijst, Bernard A.M., Boog, Claire J.P., Soethout, Ernst C.

“…Influenza infections are responsible for significant morbidity and mortality each year, with the highest infection rates found in the elderly population. The…”
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Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles by Zariri, Afshin, van Dijken, Harry, Hamstra, Hendrik-Jan, van der Flier, Michiel, Vidarsson, Gestur, van Putten, Jos P.M, Boog, Claire J.P, van den Dobbelsteen, Germie, van der Ley, Peter

“…Highlights • We developed a human-CEACAM1 transgenic mouse model. • We tested the impact of Opa proteins in outer membrane vesicles in vivo. • Opa does not…”
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Resurgence of pertussis calls for re-evaluation of pertussis animal models by van der Ark, Arno Aj, Hozbor, Daniela F, Boog, Claire J P, Metz, Bernard, van den Dobbelsteen, Germie Pjm, van Els, Cécile A C M

“…Pertussis has recently re-emerged in well-vaccinated populations most likely due to a combination of pathogen adaptation and waning of vaccine-induced…”
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Impaired production of TNF-α by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza by Liu, Wai Ming, Nahar, Thamar E.R, Jacobi, Ronald H.J, Gijzen, Karlijn, van Beek, Josine, Hak, Eelko, Jonges, Marcel, Boog, Claire J.P, van der Zeijst, Bernard A.M, Soethout, Ernst C

“…Highlights ► We investigate DCs of healthy older (≥65 years) and young adults (20–40 years). ► DCs of older adults show an impaired activation of…”
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Principles of vaccination and possible development strategies for rational design by Boog, Claire J.P

“…Abstract Historically, apart from hygiene, vaccination can be considered as one of the most successful accomplishments of public health in the 20th century. It…”
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Impaired long-term maintenance and function of Bordetella pertussis specific B cell memory by Stenger, Rachel M, Smits, Mieke, Kuipers, Betsy, van Gaans-van den Brink, Jacqueline, Poelen, Martien, Boog, Claire J.P, van Els, Cécile A.C.M

“…Abstract Frequent occurrence of whooping cough in vaccinated populations suggests limited duration of vaccine-induced immunological memory. To investigate…”
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Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice by van Helden, Mary J.G, van Kooten, Peter J.S, Bekker, Cornelis P.J, Gröne, Andrea, Topham, David J, Easton, Andrew J, Boog, Claire J.P, Busch, Dirk H, Zaiss, Dietmar M.W, Sijts, Alice J.A.M

“…Highlights ► NK cells and CD8+ T-cells expand relatively late following pneumovirus infection. ► Memory CD8+ T-cells support type 1 skewing of…”
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Immunodominance in Mouse and Human CD4⁺ T-Cell Responses Specific for the Bordetella pertussis Virulence Factor P.69 Pertactin by Stenger, Rachel M, Poelen, Martien C.M, Moret, Ed E, Kuipers, Betsy, Bruijns, Sven C.M, Hoogerhout, Peter, Hijnen, Marcel, King, Audrey J, Mooi, Frits R, Boog, Claire J.P, van Els, Cécile A.C.M

“…P.69 pertactin (P.69 Prn), an adhesion molecule from the causative agent of pertussis, Bordetella pertussis, is present in cellular and most acellular vaccines…”
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High IL‐13 production by human neonatal T cells: neonate immune system regulator? by Ribeiro‐do‐Couto, Laura M., Boeije, Leonie C.M., Kroon, Jojanneke S., Hooibrink, Berend, Breur‐Vriesendorp, Birgitta S., Aarden, Lucien A., Boog, Claire J.P.

“…Neonates are highly susceptible to diseases and display biased type 2 immune responses, although no skewing to type 2 cytokines has been reported. In view of…”
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Autoreactivity against induced or upregulated abundant self-peptides in HLA-A0201 following measles virus infection by Herberts, Carla A, van Gaans-van den Brink, Jacqueline, van der Heeft, E.d, van Wijk, Margot, Hoekman, Jan, Jaye, Assan, Poelen, Martien C.M, Boog, Claire J.P, Roholl, Paul J.M, Whittle, Hilton, de Jong, A.d P.J.M, van Els, C.écile A.C.M

“…Infectious agents have been implied as causative environmental factors in the development of autoimmunity. However, the exact nature of their involvement…”
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Dynamics of measles virus protein expression are reflected in the MHC class I epitope display by Herberts, Carla A, Meiring, Hugo M, van Gaans-van den Brink, Jacqueline A.M, van der Heeft, Ed, Poelen, Martien C.M, Boog, Claire J.P, de Jong, Ad P.J.M, van Els, Cécile A.C.M

“…Following measles virus (MV) infection, viral peptides are presented to CTL by MHC class I molecules on infected antigen presenting cells at widely different…”
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Tolerance controls encephalitogenicity of αB-crystallin in the Lewis rat by van Stipdonk, Marianne J.B, Willems, Astrid A, Plomp, Arianne C, van Noort, Johannes M, Boog, Claire J.P

“…The myelin-associated protein, αB-crystallin, is considered a candidate autoantigen in multiple sclerosis (MS). In the present study, we examined the potential…”
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Ultrastructural characterization of effector-target interactions for human neonatal and adult NK cells reveals reduced intercellular surface contacts of neonatal cells by Ribeiro-do-Couto, Laura M, Poelen, Martien, Hooibrink, Berend, Dormans, Jan A.M.A, Roholl, Paul J.M, Boog, Claire J.P

“…Limitations in neonatal natural killer (NK) cell responses may be associated with the less efficient newborn capacity to solve viral infections. Although these…”
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Immunologic monitoring of the beneficial effect of one HLA-DR-shared blood transfusion in heart transplant patients by Vaessen, L M, van Miert, P P, van der Mast, B J, Doumaid, K, Balk, A H, Boog, C J, Weimar, W

“…Pre-transplant blood transfusion (BT) results in better graft survival in organ transplant recipients, especially when BT donor and allograft recipient share…”
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The bone marrow functions as the central site of proliferation for long-lived NK cells by van Helden, Mary J G, de Graaf, Natascha, Boog, Claire J P, Topham, David J, Zaiss, Dietmar M W, Sijts, Alice J A M

“…NK cells play an important role in the early defense against invading pathogens. Although it is well established that infection leads to a substantial, local…”
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Age related differences in dynamics of specific memory B cell populations after clinical pertussis infection by van Twillert, Inonge, van Gaans-van den Brink, Jacqueline A M, Poelen, Martien C M, Helm, Kina, Kuipers, Betsy, Schipper, Maarten, Boog, Claire J P, Verheij, Theo J M, Versteegh, Florens G A, van Els, Cécile A C M

“…For a better understanding of the maintenance of immune mechanisms to Bordetella pertussis (Bp) in relation to age, we investigated the dynamic range of…”
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Differential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussis by Fransen, Floris, Stenger, Rachel M, Poelen, Martien C M, van Dijken, Harry H, Kuipers, Betsy, Boog, Claire J P, van Putten, Jos P M, van Els, Cécile A C M, van der Ley, Peter

“…Neisseria meningitidis and Bordetella pertussis are Gram-negative bacterial pathogens that can cause serious diseases in humans. N. meningitidis outer membrane…”
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Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. pertussis with age by Han, Wanda G H, van Twillert, Inonge, Poelen, Martien C M, Helm, Kina, van de Kassteele, Jan, Verheij, Theo J M, Versteegh, Florens G A, Boog, Claire J P, van Els, Cécile A C M

“…Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective…”
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