Search Results - "Boocock, D J"

Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA by Boocock, David J., Brown, Karen, Gibbs, Anthony H., Sanchez, Esther, Turteltaub, Kenneth W., White, Ian N.H.

“…This study investigates which CYP forms are responsible for the conversion of tamoxifen to its putative active metabolite α-hydroxytamoxifen and irreversible…”
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Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer by Buczek, M E, Miles, A K, Green, W, Johnson, C, Boocock, D J, Pockley, A G, Rees, R C, Hulman, G, van Schalkwyk, G, Parkinson, R, Hulman, J, Powe, D G, Regad, T

“…Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as…”
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Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of α-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen–DNA adducts by Boocock, David J., Maggs, James L., Brown, Karen, White, Ian N.H., Park, B.Kevin

“…Tamoxifen is a hepatic genotoxin in rats and mice but a hepatocarcinogen only in rats. It is not associated with DNA adducts and liver tumours in patients. The…”
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α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro by Boocock, David J., Maggs, James L., White, Ian N.H., Park, B. Kevin

“…The metabolic formation of α-hydroxytamoxifen, a reactive metabolite of tamoxifen in rat liver, was characterized and quantified in vitro (hepatic microsomal…”
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Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry by MARTIN, Elizabeth A, BROWN, Karen, SMITH, Lewis L, WHITE, Ian N. H, GASKELL, Margaret, AL-AZZAWI, Farook, GARNER, R. Colin, BOOCOCK, David J, MATTOCK, Elizabeth, PRING, David W, DINGLEY, Karen, TURTELTAUB, Kenneth W

“…This study was aimed to establish whether tamoxifen binds irreversibly to uterine DNA when given to women. Patients were given a single therapeutic dose of…”
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Cytoplasmic PML promotes TGF-[beta]-associated epithelial-mesenchymal transition and invasion in prostate cancer by Buczek, M E, Miles, A K, Green, W, Johnson, C, Boocock, D J, Pockley, A G, Rees, R C, Hulman, G, Van Schalkwyk, G, Parkinson, R, Hulman, J, Powe, D G, Regad, T

“…Epithelialmesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as…”
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Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose by BROWN, Karen, TOMPKINS, Elaine M, BOOCOCK, David J, MARTIN, Elizabeth A, FARMER, Peter B, TURTELTAUB, Kenneth W, UBICK, Esther, HEMINGWAY, David, HORNER-GLISTER, Emma, WHITE, Ian N. H

“…Tamoxifen is widely prescribed for the treatment of breast cancer and is also licensed in the United States for the prevention of this disease. However,…”
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Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine by IRESON, Christopher R, JONES, Donald J. L, ORR, Samantha, COUGHTRIE, Michael W. H, BOOCOCK, David J, WILLIAMS, Marion L, FARMER, Peter B, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer…”
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